Protein Alignment clumsy and Grik3

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_001074566.1
• Gene: Grik3 / 14807
• MGIID: 95816
• Length: 919
• Species: Mus musculus
• Alignment Length: 912
• Identity: 345/912 - (37%)
• Similarity: 514/912 - (56%)
• Gaps: 84/912 - (9%)

  Fly    27 VGSIFT-SDKDESEI------AFRTAVDRANILERNVELVPIVVYANT-----------DDSFIM 73
            :|.||. :|...:::      |||.:   |||:.||..|:|     ||           .|||..
Mouse    38 IGGIFEYADGPNAQVMNAEEHAFRFS---ANIINRNRTLLP-----NTTLTYDIQRIHFHDSFEA 94

  Fly    74 EKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDN 138
            .|..|:.::.||:||||||.||.::.:.|||:.|::|||...|   :..|.....|..:|::||.
Mouse    95 TKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRW---KHHPLDNKDTFYVNLYPDY 156

  Fly   139 LLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLG-PGDDHRPFLKEI 202
            ..||..:.::|||..|||.||||:....|.:||:::......:....::||. ..||.||.|||:
Mouse   157 ASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEM 221

  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFG--ELSGVEANITTVRL 265
            |...:..:|..|:.....:||:||..:.|:.||.......||.:::|..  ..|||  |:|..|:
Mouse   222 KRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGV--NLTGFRI 284

  Fly   266 MDPSDFHVKNVVHDWE-EREKREGRYFKVDPNRVKSQMI---------LLNDAVWLFSKGLTELG 320
            ::..:.||..:|..|. ||       .:..| |.:|.::         ||.|||.:.|......
Mouse   285 LNVDNPHVSAIVEKWAMER-------LQAAP-RAESGLLDGVMMTDAALLYDAVHIVSVCYQRA- 340

  Fly   321 IFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFMELNSDGFL 384
              .::|...|:|.|.|.|.||.|.:.|||....|..||||.||: :|.|:.|.|..:.|..||..
Mouse   341 --PQMTVNSLQCHRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLE 403

  Fly   385 DLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYS 449
            .:..|.|.:||::....:.....|...|:|::.||::.|..||:..|  :....|.||.|:|||.
Mouse   404 KVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTVLEEPFVMFR--KSDRTLYGNDRFEGYC 466

  Fly   450 IDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVD 514
            |||:.|:|.:|.|.:|.|:..||||||.:...| |:|:|::|||..|||.:..||:|..|.:|:|
Mouse   467 IDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQ-WNGMVKELIDHKADLAVAPLTITHVREKAID 530

  Fly   515 FTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPH 579
            |:.||||||:|||:.||......:||||:|.|.|:|:|:..|||.:|.:||.:||.:|.:|.:.|
Mouse   531 FSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAH 595

  Fly   580 PCKEPEE-VENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAF 643
            ||....| |||.::::|:.|..:||||.||.:::|||.|||::.|:||||.|::::|||||||||
Mouse   596 PCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF 660

  Fly   644 LTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDE 708
            ||..|..:.|:||:|||.|:||:|||:..|:||.||:.|..||::|||..| |:.||...|.|:|
Mouse   661 LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFM-SSKPSALVKNNEE 724

  Fly   709 GVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLG 773
            |::|.....  ||.||||||:||..:|.|:|.||||.:|.|.|||..|..||||.:|:.|:|:|.
Mouse   725 GIQRTLTAD--YALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQ 787

  Fly   774 ELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWN 838
            |..:|..:|.|||:    |..|  .:|:..:...||::.:||:|:||..||:.::::...||::.
Mouse   788 EEDKLHIMKEKWWR----GSGC--PEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYK 846

  Fly   839 VKSVAIEEKISLKEAFKSEALFA----ARIWITTKP-----------VHTSSESGSSNSSSSSSS 888
            ::..|..|:.|.......|..|:    .|:....:|           :||.::.......|.|.|
Mouse   847 LRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCS 911

  Fly   889 RS 890
            .|
Mouse   912 TS 913

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	132/401 (33%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	183/373 (49%)
Grik3	NP_001074566.1	PBP1_iGluR_Kainate	37..417	CDD:380605	132/402 (33%)
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	183/373 (49%)