Protein Alignment clumsy and Grik2

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_011241422.1
• Gene: Grik2 / 14806
• MGIID: 95815
• Length: 943
• Species: Mus musculus
• Alignment Length: 916
• Identity: 342/916 - (37%)
• Similarity: 509/916 - (55%)
• Gaps: 104/916 - (11%)

  Fly     2 YSLFLTHFLLIALPVLADIDRSQFMVGSIF----TSDKDESEIAFRTAVDRANILERNVELVP-- 60
            ||...||.|               ..|.||    :......|:|||.||   |.:.||..|:|
Mouse    28 YSQGTTHVL---------------RFGGIFEYVESGPMGAEELAFRFAV---NTINRNRTLLPNT 74

  Fly    61 IVVY----ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNES 121
            .:.|    .|..|||...|..|:.:|.||.||||||..||::.:.|||:.|.:|||...|  ...
Mouse    75 TLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRW--KHQ 137

  Fly   122 IPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTV 186
            :.|.:.| ..::::||...||:.:.::||.|.|::.||||:....|.:||::::.....:....:
Mouse   138 VSDNKDS-FYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKI 201

  Fly   187 KQLGPGD--DHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSID 249
            :|| |.|  |.:|.|||:|...:..:|..|:.:....||:||..:.|:.||.......||..::|
Mouse   202 RQL-PADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALD 265

  Fly   250 FG--ELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMI--------- 303
            ..  ..|||  |:|..|:::..:..|.:::..| ..|:.:.      |.:..|.::
Mouse   266 VEPYRYSGV--NMTGFRILNTENTQVSSIIEKW-SMERLQA------PPKPDSGLLDGFMTTDAA 321

  Fly   304 LLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQ 367
            |:.|||.:.|..:.:   |.::|...|:|.|.|||.||.|.:..||....|..||||.||: ||.
Mouse   322 LMYDAVHVVSVAVQQ---FPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGL 383

  Fly   368 RSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLRE 432
            |:.|.|..:.|..:|...:.||||.:||::....:.....:...|||::.||::.|..|::..::
Mouse   384 RTDFDLDVISLKEEGLEKIGTWDPSSGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKK 448

  Fly   433 PQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNAD 497
            ..:.  |.||.|:|||.|||:.|::.:|.|.:|.|:..||||||.:.|...|:|:||:|||..||
Mouse   449 SDKP--LYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDVNGQWNGMVRELIDHKAD 511

  Fly   498 LGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISL 562
            |.:..|.:|..|.:.:||:.||||||||||:.||......:||||:|.|.|:|:|:..|||.:|.
Mouse   512 LAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSC 576

  Fly   563 LLFALAR-----------------------------------MAPDDWENPHPCK-EPEEVENIW 591
            :||.:||                                   .:|.:|.|||||. :.:.|||.:
Mouse   577 VLFVIARQSKFSWFKYPNCSHYHHSQRCLCTQHLESYMELCLFSPYEWYNPHPCNPDSDVVENNF 641

  Fly   592 SIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSA 656
            :::|:.|..:|:||.||.:::|||.|||:|.|:||||.|::::|||||||||||..|..:.|:||
Mouse   642 TLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSA 706

  Fly   657 EDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYA 721
            :|||.|:||:|||:..|:||.||:.|..|||.|||..|.|...||..|:|:||::||....  ||
Mouse   707 DDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSD--YA 769

  Fly   722 FLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWW 786
            |||||||:|:..:|.|:|.||||.:|.|.||:..|..||||.:|:.|:|:|.|.|:|..:|.|||
Mouse   770 FLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW 834

  Fly   787 KEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLK 851
            :    |..|  .:|:..:...||::|:||:|:||..||:.::.:...|||:..|..|..||.|..
Mouse   835 R----GNGC--PEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFC 893

  Fly   852 EAFKSE 857
            .|...|
Mouse   894 SAMVEE 899

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	128/393 (33%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	183/408 (45%)
Grik2	XP_011241422.1	PBP1_iGluR_Kainate	37..414	CDD:380605	128/395 (32%)
		Periplasmic_Binding_Protein_Type_2	430..835	CDD:473866	183/408 (45%)