Protein Alignment clumsy and Grid2

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: NP_032193.1
• Gene: Grid2 / 14804
• MGIID: 95813
• Length: 1007
• Species: Mus musculus
• Alignment Length: 1052
• Identity: 257/1052 - (24%)
• Similarity: 457/1052 - (43%)
• Gaps: 181/1052 - (17%)

  Fly    17 LADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPI---VVYANTDDSFIMEKMVC 78
            ||..| |...:|:||.....:.:..|||||...|..|..::...|   |.:.:.::.|...:..|
Mouse    20 LATAD-SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEAC 83

  Fly    79 NLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYD----WIPNES---IPDREHSTMTLNVHP 136
            .|::||::|:......:|:..:.|:.|.:.|||:...    ..|...   .....:...||:|.|
Mouse    84 ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRP 148

  Fly   137 DNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL----QVGEPISNPTTVKQLGPGDDHRP 197
            . :.|::.:..:|..:||:.|.:.|:::.:::.:|:.|    |.|..::.......:.
Mouse   149 P-VYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNIN------- 205

  Fly   198 FLKEIKLSTDNCLI--LHCAPDNL---LKILQQANELKMLGEYQSVFIPLLDTHSIDFG-ELSGV 256
              |.|....|...|  |:...|.|   :.::..|.....:.|.....:...|.|.|... |::.|
Mouse   206 --KMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDV 268

  Fly   257 E---------ANITTVR-----------------------LMDPSDFHVKNVVHDWEEREKREGR 289
            :         ..:|.:|                       |.||.|...:|:
Mouse   269 DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNM------------- 320

  Fly   290 YFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRK--KPWPFGKRIIEFIKARS 352
              ::....:...::||.:|   |.|.|.:.   :..:...|.|.||  |||..|:.::|.||...
Mouse   321 --EISNLYIYDTVLLLANA---FHKKLEDR---KWHSMASLSCIRKNSKPWQGGRSMLETIKKGG 377

  Fly   353 EETSTGRIDFNENGQRSFFTLRFMELN-----SDGFLDLATWDPVNGLDVLNDDEESEKRVGQKL 412
            ....||.::|.|||.........:..|     ..|...|..|:||.||    :...::|::...:
Mouse   378 VNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGL----NGSLTDKKLENNM 438

  Fly   413 SNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGAL 477
            ......|.:.|..||:.:.|    .:|....:|:|:|||:::.::..|.|.:|..::||.|||:.
Mouse   439 RGVVLRVVTVLEEPFVMVSE----NVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSP 499

  Fly   478 NKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFL 542
            .: ..||:|:|.:|:...||:||..||:|..|...||||..:|...:.:|..: .....|:|:.|
Mouse   500 QE-DGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRR-AEKTVDMFACL 562

  Fly   543 SPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQ 607
            :||.|.:|..:....|.:.||::.|      :|.|| |..:...:.:. ::.|:.|...||.:.|
Mouse   563 APFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PRLQMGSMTST-TLYNSMWFVYGSFVQQ 619

  Fly   608 GCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAG 672
            |.::.....:||::.|.||.|||::::|||||||||||.:|..:||.|.:||:.|:.|.||.:..
Mouse   620 GGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLD 684

  Fly   673 GSTM---------GFFRDSNFSTYQKMWTAMESASPSVFTKTNDE-GVERVQKGKNLYAFLMEST 727
            .:..         .|.||   |.|.:||..:..::.|.......: |:::|:.|.  |||:.::.
Mouse   685 SAVYQHVRMKGLNPFERD---SMYSQMWRMINRSNGSENNVLESQAGIQKVKYGN--YAFVWDAA 744

  Fly   728 TLEYNV--ERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMH 790
            .|||..  :..|....:|..:..:.||||:...||||...|..:|:|.:.|.:..||.|||.:
Mouse   745 VLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPK-- 807

  Fly   791 GGGNCE-----KSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWN------VKSVAI 844
             .|.|:     .:.:.||   .|.::::.|||.:|..|::.:.::...|..|:      |.|...
Mouse   808 -NGQCDLYSSVDAKQKGG---ALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKED 868

  Fly   845 EEKISLK-----------------EAFKSEALFAARIWITTKPVHTSSE--SGSSNSSSSSSSRS 890
            :::|.|:                 :.|.:.::....:.|.|.|...:.|  |...|:..::::..
Mouse   869 DKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFI 933

  Fly   891 KHSFKSQGLSMKSLKSSGYQDVEASVH----------------SKLKKIGSMFSLKSQKTVTPPP 939
            ....::...::.:..:||:.......|                |.:|   :|.|:..|.|.|...
Mouse   934 PEQIQTLSRTLSAKAASGFAFGSVPEHRTGPFRHRAPNGGFFRSPIK---TMSSIPYQPTPTLGL 995

  Fly   940 EIGWKLDKSTQI 951
            .:|...|:.|.|
Mouse   996 NLGNDPDRGTSI 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	91/428 (21%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	123/384 (32%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		68/349 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	91/435 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/384 (32%)
		Interaction with AP4M1. /evidence=ECO:0000250|UniProtKB:Q63226	921..991		9/72 (13%)
		PDZ-binding	1005..1007		1/1 (100%)