DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grid2

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_032193.1	Gene:	Grid2 / 14804	MGIID:	95813	Length:	1007	Species:	Mus musculus

Alignment Length:	1052	Identity:	257/1052 - (24%)
Similarity:	457/1052 - (43%)	Gaps:	181/1052 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPI---VVYANTDDSFIMEKMVC 78
            ||..| |...:|:||.....:.:..|||||...|..|..::...|   |.:.:.::.|...:..|
Mouse    20 LATAD-SIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTFVDGNNPFQAVQEAC 83

  Fly    79 NLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYD----WIPNES---IPDREHSTMTLNVHP 136
            .|::||::|:......:|:..:.|:.|.:.|||:...    ..|...   .....:...||:|.|
Mouse    84 ELMNQGILALVSSIGCTSAGSLQSLADAMHIPHLFIQRSTAGTPRSGCGLTRSNRNDDYTLSVRP 148

  Fly   137 DNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL----QVGEPISNPTTVKQLGPGDDHRP 197
            . :.|::.:..:|..:||:.|.:.|:::.:::.:|:.|    |.|..::.......:.
Mouse   149 P-VYLNEVILRVVTEYAWQKFIIFYDSEYDIRGIQEFLDKVSQQGMDVALQKVENNIN------- 205

  Fly   198 FLKEIKLSTDNCLI--LHCAPDNL---LKILQQANELKMLGEYQSVFIPLLDTHSIDFG-ELSGV 256
              |.|....|...|  |:...|.|   :.::..|.....:.|.....:...|.|.|... |::.|
Mouse   206 --KMITTLFDTMRIEELNRYRDTLRRAILVMNPATAKSFISEVVETNLVAFDCHWIIINEEINDV 268

  Fly   257 E---------ANITTVR-----------------------LMDPSDFHVKNVVHDWEEREKREGR 289
            :         ..:|.:|                       |.||.|...:|:
Mouse   269 DVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGNHRISSSLCDPKDPFAQNM------------- 320

  Fly   290 YFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRK--KPWPFGKRIIEFIKARS 352
              ::....:...::||.:|   |.|.|.:.   :..:...|.|.||  |||..|:.::|.||...
Mouse   321 --EISNLYIYDTVLLLANA---FHKKLEDR---KWHSMASLSCIRKNSKPWQGGRSMLETIKKGG 377

  Fly   353 EETSTGRIDFNENGQRSFFTLRFMELN-----SDGFLDLATWDPVNGLDVLNDDEESEKRVGQKL 412
            ....||.::|.|||.........:..|     ..|...|..|:||.||    :...::|::...:
Mouse   378 VNGLTGDLEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGL----NGSLTDKKLENNM 438

  Fly   413 SNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGAL 477
            ......|.:.|..||:.:.|    .:|....:|:|:|||:::.::..|.|.:|..::||.|||:.
Mouse   439 RGVVLRVVTVLEEPFVMVSE----NVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSP 499

  Fly   478 NKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFL 542
            .: ..||:|:|.:|:...||:||..||:|..|...||||..:|...:.:|..: .....|:|:.|
Mouse   500 QE-DGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRR-AEKTVDMFACL 562

  Fly   543 SPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEEVENIWSIMNTTWLSIGSLMGQ 607
            :||.|.:|..:....|.:.||::.|      :|.|| |..:...:.:. ::.|:.|...||.:.|
Mouse   563 APFDLSLWACIAGTVLLVGLLVYLL------NWLNP-PRLQMGSMTST-TLYNSMWFVYGSFVQQ 619

  Fly   608 GCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAG 672
            |.::.....:||::.|.||.|||::::|||||||||||.:|..:||.|.:||:.|:.|.||.:..
Mouse   620 GGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSLQDLSKQTDIPYGTVLD 684

  Fly   673 GSTM---------GFFRDSNFSTYQKMWTAMESASPSVFTKTNDE-GVERVQKGKNLYAFLMEST 727
            .:..         .|.||   |.|.:||..:..::.|.......: |:::|:.|.  |||:.::.
Mouse   685 SAVYQHVRMKGLNPFERD---SMYSQMWRMINRSNGSENNVLESQAGIQKVKYGN--YAFVWDAA 744

  Fly   728 TLEYNV--ERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMH 790
            .|||..  :..|....:|..:..:.||||:...||||...|..:|:|.:.|.:..||.|||.:
Mouse   745 VLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVFSQRILELQQSGDMDILKHKWWPK-- 807

  Fly   791 GGGNCE-----KSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWN------VKSVAI 844
             .|.|:     .:.:.||   .|.::::.|||.:|..|::.:.::...|..|:      |.|...
Mouse   808 -NGQCDLYSSVDAKQKGG---ALDIKSLAGVFCILAAGIVLSCLIAVLETWWSRRKGSRVPSKED 868

  Fly   845 EEKISLK-----------------EAFKSEALFAARIWITTKPVHTSSE--SGSSNSSSSSSSRS 890
            :::|.|:                 :.|.:.::....:.|.|.|...:.|  |...|:..::::..
Mouse   869 DKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFRNTHITTTTFI 933

  Fly   891 KHSFKSQGLSMKSLKSSGYQDVEASVH----------------SKLKKIGSMFSLKSQKTVTPPP 939
            ....::...::.:..:||:.......|                |.:|   :|.|:..|.|.|...
Mouse   934 PEQIQTLSRTLSAKAASGFAFGSVPEHRTGPFRHRAPNGGFFRSPIK---TMSSIPYQPTPTLGL 995

  Fly   940 EIGWKLDKSTQI 951
            .:|...|:.|.|
Mouse   996 NLGNDPDRGTSI 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	90/428 (21%)
		ANF_receptor	39..379	CDD:279440	80/393 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	123/384 (32%)
		Lig_chan	548..812	CDD:278489	85/280 (30%)
Grid2	NP_032193.1	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250\|UniProtKB:O43424	24..345		68/349 (19%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:385651	91/435 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	123/384 (32%)
		Interaction with AP4M1. /evidence=ECO:0000250\|UniProtKB:Q63226	921..991		9/72 (13%)
		PDZ-binding	1005..1007		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846245
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740