DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Grid1

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_032192.2	Gene:	Grid1 / 14803	MGIID:	95812	Length:	1009	Species:	Mus musculus

Alignment Length:	1035	Identity:	266/1035 - (25%)
Similarity:	448/1035 - (43%)	Gaps:	153/1035 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPI-----V 62
            :|:|..::...:.|.||   |...:|:||..:..:.:..|:.||...::.:..::...|     |
Mouse     5 TLWLLPWICQCVTVRAD---SIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKV 66

  Fly    63 VYANTDDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDRE 126
            :.||.....:.|  .|:|::||::|:. .||| :|::.:.|:.|.:.|||:.....|..|    .
Mouse    67 IEANNPFQAVQE--ACDLMTQGILALV-TSTGCASANALQSLTDAMHIPHLFVQRNPGGS----P 124

  Fly   127 HSTMTLNVHPDN----------LLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPIS 181
            .:...||..||.          :.|:..:..:|....|:.|.:.|:::.:::.||..|.....:.
Mouse   125 RTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQSFLDQASRLG 189

  Fly   182 NPTTVKQLGPGDDH-----RPFLKEIKLS----TDNCLILHCAPDNLLKILQQANELKMLGEYQS 237
            ...:::::.....|     ...:|..:|:    |....||..:|......:.:|.|..:..:
Mouse   190 LDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEAVETNLASK--- 251

  Fly   238 VFIPLLDTHSIDFG-ELSGVE---------ANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFK 292
                  |:|.:... |:|..|         ..:|.||.:.||       ..|.::..:...|...
Mouse   252 ------DSHWVFVNEEISDPEILDLVHSALGRMTVVRQIFPS-------AKDNQKCMRNNHRISS 303

  Fly   293 V--DPNRVKSQMILLNDAVWLFSKGLTELGIFEEL-------TAPDLECRRK--KPWPFGKRIIE 346
            :  ||.....||:.::: ::|:...|.....|...       :...|.|.||  |||..|:.:::
Mouse   304 LLCDPQEGYLQMLQISN-LYLYDSVLMLANAFHRKLEDRKWHSMASLNCIRKSTKPWNGGRSMLD 367

  Fly   347 FIKARSEETSTGRIDFNENGQRSFFTLR-----FMELNSDGFLDLATWDPVNGLDVLNDDEESEK 406
            .||.......||.::|.|:....:....     :.|........|||||...||    :....|:
Mouse   368 TIKKGHITGLTGVMEFREDSSNPYVQFEILGTTYSETFGKDMRKLATWDSEKGL----NGSLQER 428

  Fly   407 RVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPD 471
            .:|.:|...|..|.:.|..||:.:.|    .||....||:|:|||:::.:||.|.||:|...:||
Mouse   429 PMGSRLQGLTLKVVTVLEEPFVMVAE----NILGQPKRYKGFSIDVLDALAKALGFKYEIYQAPD 489

  Fly   472 GKYGALNKVTQT-WDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPP 535
            |:||  :::..| |:|::.:||...|||.|..:|:|..|...|||:..:|...:.||..| |...
Mouse   490 GRYG--HQLHNTSWNGMIGELISKRADLAISAITITPERESVVDFSKRYMDYSVGILIKK-PEEK 551

  Fly   536 TDLFSFLSPFSLDVWIYMGSAYLFISLLLFALAR---MAPDDWENPHPCKEPEEVENIWSIMNTT 597
            ..:||..:||...||..:.:|...:.:|:|.|.|   :.......|.|....       ::.:..
Mouse   552 ISIFSLFAPFDFAVWACIAAAIPVVGVLIFVLNRIQAVRSQSATQPRPSASA-------TLHSAI 609

  Fly   598 WLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQ 662
            |:..|:.:.||.:....:.:.|:|.|.||.|.|::.:|||||||||||.||..|.|.:.:||:.|
Mouse   610 WIVYGAFVQQGGESSVNSVAMRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNPIRTFQDLSKQ 674

  Fly   663 SKIKYGAMAGGSTMGFFRDSNF------STYQKMW-TAMESASPSVFTKTNDEGVERVQKGKNLY 720
            .::.||.:...:...:||....      ||:.::| |..::...........||:.:.:||.  |
Mouse   675 LEMSYGTVRDSAVYEYFRAKGTNPLEQDSTFAELWRTISKNGGADNCVSNPSEGIRKAKKGN--Y 737

  Fly   721 AFLMESTTLEYN--VERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKR 783
            |||.:...:||.  .:..|.:..||..:..|.||||:...||||...|..:|:|.:.|.|..||:
Mouse   738 AFLWDVAVVEYAALTDDDCSVTVIGNSISSKGYGIALQHGSPYRDLFSQRILELQDTGDLDVLKQ 802

  Fly   784 KWWKEMHGGGNCEKSDEDGGDT--PELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNV------- 839
            |||...   |.|:.:......|  ..|.|.:..|||.:|.:|||.|.::...|..||.
Mouse   803 KWWPHT---GRCDLTSHSSTQTEGKSLKLHSFAGVFCILAIGLLLACLVAALELWWNSNRCHQET 864

  Fly   840 ----KSVAIE-----------EKISLKE---------AFKSEALFAARIWITTKPVHTSSESGSS 880
                |.|.:|           |.|:.|:         |.:...|..::....|:....:..|.|:
Mouse   865 PKEDKEVNLEQVHRRINSLMDEDIAHKQISPASIELSALEMGGLAPSQALEPTREYQNTQLSVST 929

  Fly   881 ---NSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTP 937
               ..||..:||:..|..|..|.:....|:....::....|   ..|.:|.....||..|
Mouse   930 FLPEQSSHGTSRTLSSGPSSNLPLPLSSSATMPSIQCKHRS---PNGGLFRQSPVKTPIP 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	88/420 (21%)
		ANF_receptor	39..379	CDD:279440	79/390 (20%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	126/385 (33%)
		Lig_chan	548..812	CDD:278489	83/277 (30%)
Grid1	NP_032192.2	Interaction with CBLN1. /evidence=ECO:0000269\|PubMed:27418511	21..436		94/445 (21%)
		PBP1_iGluR_delta_1	25..423	CDD:107387	89/425 (21%)
		PBP2_iGluR_delta_1	436..806	CDD:270448	126/385 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	931..960		8/28 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846229
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740