DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and Gria4

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_006509904.1	Gene:	Gria4 / 14802	MGIID:	95811	Length:	912	Species:	Mus musculus

Alignment Length:	908	Identity:	306/908 - (33%)
Similarity:	468/908 - (51%)	Gaps:	88/908 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SQFMVGSIFTSDKDESEIAFRTAV----DRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQ 83
            |...:|.:|..:.|:...|||.|:    ...|..|....|||.|....|.:||.:....|:..|:
Mouse    25 SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSR 89

  Fly    84 GVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEI 148
            ||.||||.....|...:.|.|..|.|..|      ..|.|....|...|.:.|.   |...|..:
Mouse    90 GVFAIFGLYDKRSVHTLTSFCSALHISLI------TPSFPTEGESQFVLQLRPS---LRGALLSL 145

  Fly   149 VQSFAWRSFTVVYETDKELQQLQDIL----QVGEPIS-------NPTTVKQLGPGDDHRPFLKEI 202
            :..:.|..|..:|:||:....||.|:    |.|..:|       |..:.:||         |:|:
Mouse   146 LDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQL---------LEEL 201

  Fly   203 KLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVE------ANIT 261
            ....:...::.|..:.|..||:|   :..:|::...:..::  .::.|.::| :|      ||:|
Mouse   202 DRRQEKKFVIDCEIERLQNILEQ---IVSVGKHVKGYHYII--ANLGFKDIS-LERFIHGGANVT 260

  Fly   262 TVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-----GI 321
            ..:|:|.:...|..::..|::.::||....:..|   |....|..|.|.:.::....|     .|
Mouse   261 GFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPP---KYTSALTYDGVLVMAETFRSLRRQKIDI 322

  Fly   322 FEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDL 386
            .....|.|.......||..|..:...:|....:..||.:.|:..|:|..:|:...||.|.|...:
Mouse   323 SRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKV 387

  Fly   387 ATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSID 451
            ..|:.::.| ||..|..:.......:.|:|.:|::.:.:|::..:  :..|:..||.:||||.:|
Mouse   388 GYWNDMDKL-VLIQDAPTLGNDTAAIENRTVVVTTIMESPYVMYK--KNHEMFEGNDKYEGYCVD 449

  Fly   452 LINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFT 516
            |.:||||.:..|::..:.|||||||.:..|:.|:|:|.:|:.|.|::.|..||:|..|.:.:||:
Mouse   450 LASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFS 514

  Fly   517 PPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDW--ENPH 579
            .|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:|  |.|.
Mouse   515 KPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPE 579

  Fly   580 PCKE--PEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAA 642
            ..||  .::..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::||||||||
Mouse   580 DGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAA 644

  Fly   643 FLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTND 707
            |||..|..:.|.||||||.|::|.||.:..|||..|||.|..:.|:||||.|.||.|||||:|..
Mouse   645 FLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTA 709

  Fly   708 EGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLK 771
            |||.||:|.|..:|||:|||..||..:|| ||.:::||.||.|.||:|.|..|..|..::.||||
Mouse   710 EGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSSLRTPVNLAVLK 774

  Fly   772 LGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGLLSAMVLGCT 833
            |.|.|.|.:||.|||   :..|.|...|....| |..|.|.||.|||.:|  ||||  ||::...
Mouse   775 LSEAGVLDKLKNKWW---YDKGECGPKDSGSKDKTSALSLSNVAGVFYILVGGLGL--AMLVALI 834

  Fly   834 EFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKS 896
            ||.:..::.|...|::                   |...|.:.:.|.|:.:.::.|....|:|
Mouse   835 EFCYKSRAEAKRMKVA-------------------KSAQTFNPTSSQNTHNLATYREADFFRS 878

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	95/395 (24%)
		ANF_receptor	39..379	CDD:279440	88/365 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	175/377 (46%)
		Lig_chan	548..812	CDD:278489	129/269 (48%)
Gria4	XP_006509904.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	98/399 (25%)
Gria4	XP_006509904.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	177/385 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846261
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.750