DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and GRIN3B

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_619635.1	Gene:	GRIN3B / 116444	HGNCID:	16768	Length:	1043	Species:	Homo sapiens

Alignment Length:	741	Identity:	169/741 - (22%)
Similarity:	291/741 - (39%)	Gaps:	149/741 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   305 LNDAVWLFSKGLTELGIFEE----LTAPDLECRRKKP----WPFGKRIIEFIKARSEETSTGRID 361
            ::|.|.|.::.|......:.    |.|| :.|...:|    .| |:.:..|:...|.:..||.:.
Human   293 IHDIVQLVARALGSAAQVQPKRALLPAP-VNCGDLQPAGPESP-GRFLARFLANTSFQGRTGPVW 355

  Fly   362 FNENGQ----RSF--FTLR--------FMELNS--DGFLDL---------------ATWDPVNGL 395
            ...:.|    |.|  ::||        :..:.|  ||.|||               ..|..:..:
Human   356 VTGSSQVHMSRHFKVWSLRRDPRGAPAWATVGSWRDGQLDLEPGGASARPPPPQGAQVWPKLRVV 420

  Fly   396 DVL--------NDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDL 452
            .:|        :.||:.:...||...:.....|:.|.|.|..|........|  .....||.|||
Human   421 TLLEHPFVFARDPDEDGQCPAGQLCLDPGTNDSATLDALFAALANGSAPRAL--RKCCYGYCIDL 483

  Fly   453 INEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTP 517
            :..:|:...|.||..:..|||||||.  ...|.|:|..|:.|.|.:.:...::.|:|.|.||||.
Human   484 LERLAEDTPFDFELYLVGDGKYGALR--DGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTS 546

  Fly   518 PFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPC- 581
            ||.:..:.|:.....| .:.:.:|:.|.....|:.:.:|....:|.|...      :|.:|:..
Human   547 PFFSTSLGIMVRARDT-ASPIGAFMWPLHWSTWLGVFAALHLTALFLTVY------EWRSPYGLT 604

  Fly   582 ---KEPEEVENIWSIMNTTWL-----SIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTA 638
               :....|.:..|.:|..:.     ::.|.       .||..:.||:..:|..|.|::|:||||
Human   605 PRGRNRSTVFSYSSALNLCYAILFRRTVSSK-------TPKCPTGRLLMNLWAIFCLLVLSSYTA 662

  Fly   639 NLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTY-QKMWTAMESASPSVF 702
            ||||.:...:....::...|    .|:.:.|.  |...|...:|:...| :|.:..|.:......
Human   663 NLAAVMVGDKTFEELSGIHD----PKLHHPAQ--GFRFGTVWESSAEAYIKKSFPDMHAHMRRHS 721

  Fly   703 TKTNDEGVERVQKG-KNLYAFLMESTTLEY--NVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQ 764
            ..|...||..:... ..|.||:|:.:.|:|  :::..|.|:.:|.....:.|||.:|.|||....
Human   722 APTTPRGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSN 786

  Fly   765 ISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMV 829
            :|..:.:....|.:..|..||:|.:    .|.|......:|.::.:.:..|:|::|.|||.||::
Human   787 LSEFISRYKSSGFIDLLHDKWYKMV----PCGKRVFAVTETLQMSIYHFAGLFVLLCLGLGSALL 847

  Fly   830 --LGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWI-TTKPVHTSSESGSSNSSSSSSSRSK 891
              ||...|.          :::|....|...|   :.|: |::.:|.:..:.....|...::.::
Human   848 SSLGEHAFF----------RLALPRIRKGSRL---QYWLHTSQKIHRALNTEPPEGSKEETAEAE 899

  Fly   892 HSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPPPEIGWK-----LDKSTQI 951
            .|                              |.....:.|:...|....|||     :||..::
Human   900 PS------------------------------GPEVEQQQQQQDQPTAPEGWKRARRAVDKERRV 934

  Fly   952 D--------VVPTSDVDQELIPEVEP 969
            .        |.|.:|.:.|..|...|
Human   935 RFLLEPAVVVAPEADAEAEAAPREGP 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	27/129 (21%)
		ANF_receptor	39..379	CDD:279440	20/95 (21%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	100/385 (26%)
		Lig_chan	548..812	CDD:278489	63/276 (23%)
GRIN3B	NP_619635.1	PBP1_iGluR_NMDA_NR3	19..405	CDD:107372	26/113 (23%)
		PBP2_iGluR_NMDA_Nr3	415..808	CDD:270438	104/416 (25%)
		Lig_chan	576..842	CDD:278489	67/288 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155828
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740