Protein Alignment clumsy and grik3

DIOPT Version :10

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_031752773.1
• Gene: grik3 / 100498426
• XenbaseID: XB-GENE-6050069
• Length: 919
• Species: Xenopus tropicalis
• Alignment Length: 866
• Identity: 323/866 - (37%)
• Similarity: 508/866 - (58%)
• Gaps: 59/866 - (6%)

  Fly    39 EIAFRTAVDRANILERNVELVP--IVVY----ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSS 97
            |.|||.:   |:|:.||..|:|  .:.|    .|..|||...:..|:.::.||:||||||..|||
 Frog    57 EQAFRFS---ASIINRNRTLLPNTTLTYDIQRINLYDSFEANRKACDQLALGVVAIFGPSHSSSS 118

  Fly    98 DIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYE 162
            :.:.|||:.|::|||...| .:..:.:|:  :..:|::||...||..:.::||...|||.||||:
 Frog   119 NAVQSICNALEVPHIQVRW-KHHPLDNRD--SFYVNLYPDYASLSHAILDLVQFLKWRSATVVYD 180

  Fly   163 TDKELQQLQDILQVGEPISNPTTVKQLGP-GDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQA 226
            ....|.:||:::......:....::||.| .:|.||.|||:|...:..:|..|:.....:||:||
 Frog   181 DSTGLIRLQELIMAPARYNIRLKIRQLPPESEDARPLLKEMKRGREFRIIFDCSHTMAAQILRQA 245

  Fly   227 NELKMLGEYQSVFIPLLDTHSIDFG--ELSGVEANITTVRLMDPSDFHVKNVVHDWE-EREKREG 288
            ..:.|:.||.......||.:::|..  ..|||  |:|..|:::..:.:|.::|..|. ||.:...
 Frog   246 MAMGMMTEYYHYIFTTLDLYALDLEPYRYSGV--NLTGFRILNVDNPYVSSIVDKWSMERHQATP 308

  Fly   289 RYFKVDPNR------VKSQMILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEF 347
            :     |..      :.:...|..|||.:.|......   .::|...|:|.|.|.|.||.|.:.|
 Frog   309 K-----PESGLLDGIMTTDAALTYDAVHIVSVCYQRA---PQMTVNSLQCHRHKAWRFGSRFMNF 365

  Fly   348 IKARSEETSTGRIDFNE-NGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQK 411
            ||....|..||||.||: :|.|:.|.|..:.|..||...:.||:|.:||::..........:.:.
 Frog   366 IKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGTWNPSDGLNITETARGRGPNISES 430

  Fly   412 LSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGA 476
            |:|:|.||::.|..|::..:  :....|.|..|:||:.|||:.:||::|.|.::.|:..|.|||:
 Frog   431 LTNRTLIVTTVLEEPYVMFK--RSDTPLFGKDRFEGFCIDLLKKIAEILGFDYDIRLVEDAKYGS 493

  Fly   477 LNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSF 541
            .::..| |:|:|::|||..|||.:..||:|..|.:.:||:.||||||||||:.|.......:|||
 Frog   494 QDEKGQ-WNGLVKELIDHKADLAVAPLTITHVREKVIDFSKPFMTLGISILYRKANGTAPSVFSF 557

  Fly   542 LSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKE-PEEVENIWSIMNTTWLSIGSLM 605
            |:|.|.|:|:|:..|||.:|.:||.:||.:|.:|.:.|||.. .:.|||.::::|:.|.::|:||
 Frog   558 LNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGTDVVENNFTLLNSFWFAVGALM 622

  Fly   606 GQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAM 670
            .||.:::|||.|||::.|:||||.|::::|||||||||||..|..::|:||:|||.|:||:|||:
 Frog   623 QQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESAIDSADDLAKQTKIEYGAV 687

  Fly   671 AGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVER 735
            ..|:||.||:.|:.||::|||..| |:.||...|:|:||::||....  ||.|||||.:||..:|
 Frog   688 VDGATMNFFKKSHISTFEKMWAFM-SSRPSALVKSNEEGIQRVLSAD--YALLMESTAIEYITQR 749

  Fly   736 KCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDE 800
            .|:|.||||.:|.|.|||..|..||||.:||.|:|:|.|..::.::|.:||:    .|.|  .:|
 Frog   750 NCNLTQIGGLIDSKGYGIGTPMGSPYRDRISIAILQLQEADEIHKMKERWWR----SGGC--PEE 808

  Fly   801 DGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIW 865
            ...:...||::|:||:|:||..||:.::|:...||::.::..|..|:.|.......|    .|:.
 Frog   809 KNKEASALGIQNMGGIFIVLAGGLILSVVVAMAEFVYKLRKTAEREQRSFCSTMADE----IRLS 869

  Fly   866 ITTK---------PVHTSSES 877
            :|.:         ||...|::
 Frog   870 LTCQRRVKHKPQPPVMVKSDA 890

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	27..397	CDD:380605	123/374 (33%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	173/373 (46%)
grik3	XP_031752773.1	PBP1_iGluR_Kainate	37..417	CDD:380605	123/375 (33%)
		Periplasmic_Binding_Protein_Type_2	433..801	CDD:473866	173/373 (46%)