DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and grik5

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_002936446.1	Gene:	grik5 / 100497490	XenbaseID:	XB-GENE-953974	Length:	995	Species:	Xenopus tropicalis

Alignment Length:	852	Identity:	288/852 - (33%)
Similarity:	462/852 - (54%)	Gaps:	87/852 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 YANTDDSFIMEKMVCNLISQGVIAIFGPSTG-SSSDIIASICDTLDIPHIVYDWIPNESIPDREH 127
            |..||       .:|.::.:||:::.||||. :|:..::.||...:||||.   :..|..|..::
Frog    80 YETTD-------TMCQILPKGVVSVLGPSTSPASASTVSHICGEKEIPHIK---VGPEEAPKLQY 134

  Fly   128 STM-TLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGP 191
            ... :::::|.|..:|..::.|::||...|.:::....:.|.:|:::::......:..:|:.|..
Frog   135 LRFASVSLYPSNEDISLAVSHILKSFHNPSTSLICAKAECLLRLEELVRQFLISKDTLSVRMLDE 199

  Fly   192 GDDHRPFLKEI---KLST----DNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSID 249
            .:|..|.||||   |:||    .|..:.|.       ||::|:||.|...:....:..:|...:.
Frog   200 SNDPTPLLKEIRDDKVSTIIIDANATVSHL-------ILKKASELGMTSAHYKYILTTMDFPLLS 257

  Fly   250 FGELSGVEANITTVRLMDPS-----DFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMI------ 303
            ...:...::||....:.:.|     :| ::::...|.|             |...|..:
Frog   258 LEGIVSDQSNILGFSMYNSSHPFYLEF-LRSLNMSWRE-------------NCELSTYLGPALSA 308

  Fly   304 -LLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQ 367
             |:.|||.:....:.||...:|:....|.|...:.|..|..::.:::....:..|||::||..||
Frog   309 ALMFDAVHVVVSAVRELNRSQEIGVKQLSCSTSQIWQHGTSLMNYLRMVEYDGLTGRVEFNSKGQ 373

  Fly   368 RSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLRE 432
            |:.:|||.:|...||..::..|  .:...:..:....:....:.|.|||.:|::.|..|::..:.
Frog   374 RTNYTLRILEKAGDGHREIGVW--YSNRTLAMNATSLDLSTSETLENKTLVVTTILENPYMMRKS 436

  Fly   433 PQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNAD 497
            ....  |:||.:|||:..:::.|:|.:|.|.::.::..||.||| .:...:|.|:|.:||:..||
Frog   437 NYRS--LSGNDQYEGFCAEMLMELAALLRFNYKIKLVEDGLYGA-PEPNGSWTGMVGELINRKAD 498

  Fly   498 LGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISL 562
            |.:...|:|:.|.:.:||:.||||||||||:..........||||.|||..||::|..|||.:|.
Frog   499 LAVAAFTITAEREKVIDFSKPFMTLGISILYRVQMGRKPGYFSFLDPFSPAVWLFMLLAYLAVSC 563

  Fly   563 LLFALARMAPDDWENPHPC-KEPEEV-ENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMW 625
            :||..||::|.:|.||||| :|...: ||.:::.|:.|..:|..|.||.:::|:|.|||.|:|:|
Frog   564 VLFLAARLSPYEWYNPHPCLRERHHILENQYTLGNSLWFPVGGFMQQGSEVMPRALSTRCVSGVW 628

  Fly   626 WFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKM 690
            |.|.|::::|||||||||||..|....|.||:|||.|:.|:||.:.|||||.||::|.:.|||:|
Frog   629 WAFTLIIISSYTANLAAFLTVQRMEVPIESADDLADQTNIEYGTIHGGSTMTFFQNSRYQTYQRM 693

  Fly   691 WTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAM 755
            |..|.|..||||.|:.:||:.||...:  ||||:|||..||:....|:|.||||.||.|.|||.|
Frog   694 WNYMNSKQPSVFVKSTEEGIARVLNSR--YAFLLESTMNEYHRRLNCNLTQIGGLLDTKGYGIGM 756

  Fly   756 PFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVL 820
            |..||||.:|:.|:|:|.|..:|..||||||:    ||.|.|  |:......||:||:||:|:||
Frog   757 PLGSPYRDEITLAILQLQENNRLEILKRKWWE----GGKCPK--EEDHRAKGLGMENIGGIFVVL 815

  Fly   821 GLGLLSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSS 885
            ..||:.|:.:...||:|:.:.....|:||:.:...||...|.                    |..
Frog   816 ICGLIIAVFVAIMEFVWSTRRSVDNEEISVCQEMLSELRSAV--------------------SCK 860

  Fly   886 SSSRSKH 892
            .:|||:|
Frog   861 KTSRSRH 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	82/352 (23%)
		ANF_receptor	39..379	CDD:279440	79/335 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	173/374 (46%)
		Lig_chan	548..812	CDD:278489	130/265 (49%)
grik5	XP_002936446.1	PBP1_iGluR_Kainate_KA1_2	27..405	CDD:380616	82/357 (23%)
grik5	XP_002936446.1	Periplasmic_Binding_Protein_Type_2	418..788	CDD:389745	173/374 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930