Protein Alignment clumsy and grin3b

DIOPT Version :9

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_017952374.2
• Gene: grin3b / 100497172
• XenbaseID: XB-GENE-990106
• Length: 1005
• Species: Xenopus tropicalis
• Alignment Length: 1041
• Identity: 215/1041 - (20%)
• Similarity: 396/1041 - (38%)
• Gaps: 254/1041 - (24%)

  Fly    78 CNLISQ--------GVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIP-NESI-----PDREHS 128
            |.::::        .::..:|.:.....::::.|..|        .|:| |.|:     ..|:.|
 Frog    27 CRILARIGHTVRLGALLPSYGHTQARIQNVLSRISRT--------SWLPYNLSLEVVSGAPRDRS 83

  Fly   129 TMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGD 193
            ..:|......:|::||:|.::      :|....|...:|:.|...|::  |..:....:|:.|..
 Frog    84 PASLTRWLCQVLVAQGIAAVL------AFPQAQEELLQLEFLSSFLEI--PFISILEQEQIVPLA 140

  Fly   194 DHRPF--LKEIKLSTDNCL----------------ILHCAPDNLLKI---------LQQANELKM 231
            ...||  ..:.:.|.:|.:                |:.|.|.:...|         |.....|.:
 Frog   141 TKNPFHLQMDTQSSVENLMDIFFSVLQNSSWEEVDIITCHPWDSASIQRYLTSNTTLVSRTILNI 205

  Fly   232 LGEYQSVFIPLLDTHSIDFGE------LSGVEANITTVRL-------MDPSDFHVKNVVHDW--- 280
            ....:|..:|.|..|......      |.|.:|..:::..       ::..:||       |
 Frog   206 HPVDESALVPFLQQHFESMKNPQFPMLLYGCDARRSSLVFRVARDCGLEAHEFH-------WMIG 263

  Fly   281 ----EEREKREG------RYFKVD-PNRVKSQMILLNDAVWLFSKGLT-------ELGIFEELTA 327
                .|....||      .|.:|. |...|    .:.|||.|.::.::       :|.:.:.:
 Frog   264 HPLNGEEMTTEGMPPGLLAYGEVSRPTMEK----FIRDAVGLVTRAISAAVHVRPDLALIQSM-- 322

  Fly   328 PDLEC---RRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATW 389
              :.|   :.|:....|..:..|:...|....||:|..:.|...:....|...|..|...| .||
 Frog   323 --VNCNDKQTKQNESSGSYLSRFLANTSFSGQTGQIYVSNNLIHTEHHYRIWSLVRDSLGD-PTW 384

  Fly   390 DPVNG-----LDVLNDDEES--EKRVGQ-----------KLSNKTFIVSSRLGAPFLTLREPQ-- 434
            ..|.|     ::|    ||.  :.|:.|           ||...|.:..     ||:..||..
 Frog   385 VTVGGWRQGKMEV----EEGLWQSRIQQWEPAPGGFARTKLRVVTLVEH-----PFVFTREVDAD 440

  Fly   435 ----EGEIL----TGNS-------------------RYE----GYSIDLINEIAKMLNFKFEFRM 468
                .|::.    |.||                   .|:    ||.|||:.::::.|.|.||..:
 Frog   441 GSCPAGQMCLDPRTNNSAVLDVLFEELNSPNGSVPLEYKTCCYGYCIDLLEKLSEDLRFDFELYI 505

  Fly   469 SPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILFSKPPT 533
            ..||||||  :....|.|:|..|:.|.|.:.:...::.|:|...:|||.||.:..:.||.....|
 Frog   506 VGDGKYGA--RKGDRWTGLVGDLLSGAAHMAVTSFSINSARSTVIDFTSPFYSTSLGILVRMRDT 568

  Fly   534 PPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWEN-----PHPCKEPEEVENIWSI 593
             .:.:.:|:.|....:|:     .:|::|.:.||. :...:|::     ||.....:    |:|.
 Frog   569 -ASPIGAFMWPLHWSMWV-----GIFVALHITALF-LTFYEWKSPFGMTPHGRNRTK----IFSY 622

  Fly   594 MNTTWLSIGSLMGQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAE 657
            .:...|....|.|:.... .||..:.|::..:|..|.|::|:||||||||.:...:...:::...
 Frog   623 SSALNLCYAILFGRTVSSKTPKCCTGRVLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEALSGIH 687

  Fly   658 DLAAQSKIKYGAMAGGSTMGFFRDSNFSTY-QKMWTAMESASPSVFTKTNDEGVERVQKG-KNLY 720
            |    .|:.:.:.  |...|...:|:...| :|.:..|.:...........:||..::.. ..|.
 Frog   688 D----PKLHHPSQ--GFRFGTVWESSAEQYIKKSFPEMHNYMRKFSVPATSDGVHLLKTDPPTLN 746

  Fly   721 AFLMESTTLEY--NVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKR 783
            ||:|:...|:|  :::..|.|:.||.....:.|||.:|.|||....||..:.:....|.:..|..
 Frog   747 AFIMDKALLDYEVSIDSDCKLLTIGKPFAIEGYGIGLPQNSPLTSNISEFISRYKSSGFMDTLHD 811

  Fly   784 KWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTE-------------- 834
            ||:|.:    .|.|......:|.::|:.:..|:|::|.:|...:::....|
 Frog   812 KWYKMV----PCGKRVYAVTETLQMGIYHFSGLFVLLCIGFCGSLLTSLMERVVYHLILPRIRRR 872

  Fly   835 -----FLWNVKSV------------AIEEKISLKEAFKSEALFAAR-IW--ITTKP------VHT 873
                 :|...:.:            |:..|::.:...:.:|..|.: :|  :...|      ||.
 Frog   873 RRFKYWLHTSQKIHRALNMTCEDQDALSPKLNKRCNLQKDATGAPQSVWNNLRRTPAHQERRVHF 937

  Fly   874 SSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPP 938
            :.|..|:......:.|.|      |:..:.||     ::|..:....:::.:....|||..|...
 Frog   938 NLEKASAREGLCENGRPK------GIKQEELK-----ELEVKIEGMKEQLRAALVRKSQLMVILQ 991

  Fly   939 P 939
            |
 Frog   992 P 992

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	72/400 (18%)
		ANF_receptor	39..379	CDD:279440	65/378 (17%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	104/415 (25%)
		Lig_chan	548..812	CDD:278489	66/273 (24%)
grin3b	XP_017952374.2	PBP1_iGluR_NMDA_NR3	29..402	CDD:380600	74/408 (18%)
		PBP2_iGluR_NMDA_Nr3	418..814	CDD:270438	105/419 (25%)
		Lig_chan	582..848	CDD:395014	69/285 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910