DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and grik4

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_031761990.1	Gene:	grik4 / 100490768	XenbaseID:	XB-GENE-1011875	Length:	962	Species:	Xenopus tropicalis

Alignment Length:	805	Identity:	291/805 - (36%)
Similarity:	438/805 - (54%)	Gaps:	41/805 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 DDSFIMEKMVCNLISQGVIAIFGPS-TGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMT 131
            |..:...:.:|.::.:||:.:.||| :.|||.||::||...::|||...  ..|.:..:.....|
Frog    73 DSEYETAETMCQILPKGVLGVLGPSYSPSSSSIISNICGEKEVPHIKVS--TEEFLRFQYQRFTT 135

  Fly   132 LNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHR 196
            ||:||.|..:|..:|.:::.|...:..::....:.|..|:.:|:......:..:|:.|....|..
Frog   136 LNLHPSNTDISAAVATLLRFFNSTTACLICAKAECLLNLEKLLRQFLISKDCLSVRMLDDTWDPT 200

  Fly   197 PFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANIT 261
            |.||||:....:.:|:|........||.:|.||.|:..|.:.....|:.....|........||.
Frog   201 PLLKEIRDDKTSTIIVHANASMSHTILMKAAELGMVTAYYTYIFTNLEFVLQRFESPLDDRVNIL 265

  Fly   262 TVRLMDPSDFHVKNVVH----DWEEREKREGRYFKVDPNRVKSQMI---LLNDAVWLFSKGLTEL 319
            ...:.:.|..:.|...|    .|||         ..|.:......:   ||.|||:.....:.||
Frog   266 GFSMFNQSHSYFKEFAHTLQQSWEE---------NCDHSPFTGPALSAALLFDAVYGIVSAVQEL 321

  Fly   320 GIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFL 384
            ...:|:....|.|...:.|..|..::.:::....|..||.::||..||||.:.::.|:....||.
Frog   322 NRSQEIGVKPLSCGSSQIWQHGTSLMNYLRMVELEGLTGHVEFNSKGQRSNYDMKIMQYTKTGFQ 386

  Fly   385 DLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRL----GAPFLTLR-EPQEGEILTGNSR 444
            ::..|...|||::  |...........|.|||.||::.|    ..|:|.|: ..||   |.||.|
Frog   387 EIGQWHVTNGLNM--DKRYFSPNASDTLVNKTLIVTTILFFLQENPYLMLKANHQE---LEGNDR 446

  Fly   445 YEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSR 509
            |||:.:|::.|:|.:|.|.::.|:..||.|| :.::..||.|:|.:||...|||.:..||:|:.|
Frog   447 YEGFCVDMLKELAAILRFNYKIRLVADGVYG-VPELNGTWTGMVGELISRKADLAVAGLTITAER 510

  Fly   510 RQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDD 574
            .:.:||:.||||||||||:..........||||.|||..||::|..|||.:|.:||.:||:.|.:
Frog   511 EKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGVWLFMLLAYLAVSCVLFLVARLTPYE 575

  Fly   575 WENPHPCKEP--EEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYT 637
            |.:||||.:.  ..:.|.:|:.|:.|..:|..|.||..|.|:|.|||.|:|:||.|.|::::|||
Frog   576 WYSPHPCAQGRCNLLVNQYSLGNSLWFPVGGFMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYT 640

  Fly   638 ANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVF 702
            ||||||||..|....|.|.:|||.|:.|:||.:.|||:|.||::|.:.|||:||..|.|..||||
Frog   641 ANLAAFLTVQRMDVPIESVDDLADQTTIEYGTIHGGSSMTFFQNSRYQTYQRMWNYMHSKQPSVF 705

  Fly   703 TKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISA 767
            .|:.:||:.||....  ||||:|||..||..:|.|:|.|:||.||.|.|||.||..|.:|.:...
Frog   706 VKSTEEGIARVLNSN--YAFLLESTMNEYYRQRNCNLTQVGGLLDTKGYGIGMPVGSAFRDEFDL 768

  Fly   768 AVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGC 832
            |:|:|.|...|.:||||||    .||.|.|  |:......||:||:||:|:||..||:.|:::..
Frog   769 AILQLQENNCLEDLKRKWW----DGGKCPK--EEDHRAKGLGMENIGGIFVVLICGLIVAILIAM 827

  Fly   833 TEFLWNVKSVAIEEKISLKEAFKSE 857
            .||||.|:: |.:.::|:.:...||
Frog   828 LEFLWTVRN-AEDSEVSVCQEMASE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	85/335 (25%)
		ANF_receptor	39..379	CDD:279440	80/318 (25%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	176/379 (46%)
		Lig_chan	548..812	CDD:278489	124/265 (47%)
grik4	XP_031761990.1	Periplasmic_Binding_Protein_type1	23..400	CDD:415822	86/339 (25%)
grik4	XP_031761990.1	PBP2_iGluR_kainate_KA1	414..788	CDD:270442	177/383 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020