Protein Alignment clumsy and grin2b

DIOPT Version :9

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_017948700.2
• Gene: grin2b / 100490580
• XenbaseID: XB-GENE-949327
• Length: 1449
• Species: Xenopus tropicalis
• Alignment Length: 1093
• Identity: 239/1093 - (21%)
• Similarity: 440/1093 - (40%)
• Gaps: 233/1093 - (21%)

  Fly     9 FLLIALPVL----------ADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILERNVELVPIV- 62
            :|.|:|.:|          .::|.:..:||   |:|    |:|.:...::.:.  .::.:.|.|
 Frog     9 YLKISLIILFYMGCYAQKHPNMDIAVILVG---TTD----EVAIKDVHEKDDF--HHLPVTPRVA 64

  Fly    63 -VYANTDDSFIMEKMVCNLIS----QGVIAIFGPSTGSSSDIIASICDTLDI----PHIVYDWIP 118
             |..|..|...:...:|:|:|    |||  :||..|  ..:.||.|.|.:.:    |.:......
 Frog    65 LVTMNESDPKSIITRICDLMSDKKVQGV--VFGDDT--DQEAIAQILDFISVQTLTPILGIHGGS 125

  Fly   119 NESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNP 183
            :..:.|:|.::|.....|.....:..:..|::.:.|..|::|.......|..::  :|...|.|.
 Frog   126 SMIMADKEEASMFFQFGPSIEQQASVMLNIMEEYDWYIFSIVTTYFPGYQDFEN--KVRSTIENS 188

  Fly   184 TTVKQL--------GPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFI 240
            ....:|        ...|:......::|......::|:|..:....|.:.|:.:.:.|...:..:
 Frog   189 FVGWELEEVIHLDMSLDDNDSKIQNQLKKLQSPVILLYCTKEEATYIFEVAHSVGLTGYGYTWIV 253

  Fly   241 PLLDTHSIDFGELSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVD-PNRVKSQMIL 304
            |.|            |..:..||    |::|....:...::|        :..| |.||:..:.:
 Frog   254 PSL------------VAGDTDTV----PAEFPTGLISVSYDE--------WDYDLPARVRDGIAI 294

  Fly   305 LNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARS---EETSTGR-IDFNEN 365
            :..|      ..|.|.....:......|...:.    .|:.|....:.   ..|..|| :.|:|:
 Frog   295 ITTA------ASTMLSEHNSIPQSKSSCYNIQE----SRVYEAHMLKRYLINVTFEGRNLSFSED 349

  Fly   366 GQRSFFTLRFMELNSDGFLDLATWDPVNGL------------DVLNDDEESEKRVGQKLSNKTFI 418
            |.:....|..:.||..     ..|:.|...            .|......||:...:.||    |
 Frog   350 GYQMHPKLVIILLNQQ-----RKWERVGKYKDRSLKMKYYVWPVFELYPNSEEHKDEHLS----I 405

  Fly   419 VSSRLGAPFLTLRE-------------PQEGEILTGNSRYE----------GYSIDLINEIAKML 460
            |:.. .|||:.:.:             |...:|.|.|...|          |:.||::.:|||.:
 Frog   406 VTLE-EAPFVIVEDVDPLSGTCMRNTVPCRKQIRTENRTEEGGNYIKRCCKGFCIDILKKIAKTV 469

  Fly   461 NFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGIS 525
            .|.::..:..:||:|  .|:..||:|::.:::...|.:.:..||:...|.:.|||:.||:..|||
 Frog   470 KFTYDLYLVTNGKHG--KKINGTWNGMIGEVVTKRAYMAVGSLTINEERSEVVDFSVPFIETGIS 532

  Fly   526 ILFSKP--PTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENP---HPC---- 581
            ::.|:.  ...|:   :||.|||.|||:.|     |:.||:.:...:...::.:|   :.|
 Frog   533 VMVSRSNGTVSPS---AFLEPFSADVWVMM-----FVMLLIVSAVAVFVFEYFSPVGYNRCLADG 589

  Fly   582 KEPEEVENIWSIMNTTWLSIGSLMGQGCDIL-PKAASTRLVTGMWWFFALMMLNSYTANLAAFLT 645
            :||....  ::|....||..|.:......:. ||..:::::..:|.|||::.|.|||||||||:.
 Frog   590 REPGGPS--FTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMI 652

  Fly   646 NSRQANSINSAEDLAAQ------SKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTK 704
            .....:.::...|...|      ...::|.:..|||....|::    |.:|.:.|        .|
 Frog   653 QEEYVDQVSGLSDKKFQRPNDFSPAFRFGTVPNGSTERNIRNN----YLEMHSYM--------VK 705

  Fly   705 TNDEGVE----RVQKGKNLYAFLMESTTLEYNVERK--CDLVQIGGWLDYKS--YGIAMPFNSPY 761
            .|...|:    .::.|| |.||:.::..|.|...|.  |.||.||....:.:  ||||:..:|.:
 Frog   706 FNQRSVQDALLSLKTGK-LDAFIYDAAVLNYMAGRDEGCKLVTIGSGKVFATTGYGIAIQKDSGW 769

  Fly   762 RKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLS 826
            ::|:..|:|:|...|::.||:..|..     |.|. ::::...:.:|.::|:.|||.:|...:..
 Frog   770 KRQVDLAILQLFGDGEMEELEALWLT-----GICH-NEKNEVMSSQLDIDNMAGVFYMLAAAMAL 828

  Fly   827 AMVLGCTE--FLWNVKSVAIEEKISLKEAF------KSEALFAAR---------IWITTKPVHTS 874
            :::....|  |.|           .|:..|      |...:|:..         :.|..:....:
 Frog   829 SLITFIMEHLFFW-----------QLRHCFMGVCSGKPGVVFSISRGIYSCIHGVPIEDRQSAMN 882

  Fly   875 SESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQDVEASVHSKLKKIGSMFSLKSQKTVTPPP 939
            |.|.:.|::.|:..|...:.|    :|.:|  ||......|....:::..|::.:...:......
 Frog   883 SPSATMNNTHSNILRLLRTAK----NMANL--SGVNGSPQSALDFIRRESSVYDISEHRRSFTHS 941

  Fly   940 EIGWKLDKSTQIDVVPTSDVDQELIPEVEPHLPH--------RHHHHHHHRHH 984
            :.     ||.|    |..::..:.|.|||....:        ...|.||||.|
 Frog   942 DC-----KSFQ----PEENLFSDYISEVERTFGNLQLKDSNVYQDHFHHHRPH 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	74/404 (18%)
		ANF_receptor	39..379	CDD:279440	66/362 (18%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	113/419 (27%)
		Lig_chan	548..812	CDD:278489	73/285 (26%)
grin2b	XP_017948700.2	PBP1_iGluR_NMDA_NR2	28..383	CDD:380601	75/408 (18%)
		PBP2_iGluR_NMDA_Nr2	400..800	CDD:270436	117/435 (27%)
		NMDAR2_C	837..1449	CDD:402274	33/175 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910