DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and LOC100334689

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_017206939.1	Gene:	LOC100334689 / 100334689	-ID:	-	Length:	991	Species:	Danio rerio

Alignment Length:	932	Identity:	327/932 - (35%)
Similarity:	518/932 - (55%)	Gaps:	76/932 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDK------DESEIAFRTAVDRANILERNVELVP--IVVY----ANTDDSFIMEKMVCN 79
            :|.||....      ...|:||:.||:..|   ||..|:|  .:.|    .|..|||...:..|:
Zfish    33 IGGIFEQTDGPVALVSSEELAFKFAVNNIN---RNRTLLPNTTLTYDIQRINIYDSFEASRKACD 94

  Fly    80 LISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQG 144
            .:|.||:||||||..|||:.:.|||:.|::|||...|   :..|.....|...|::||...||..
Zfish    95 QLSLGVVAIFGPSHSSSSNAVQSICNALEVPHIQVRW---KHHPMDNRDTFYANLYPDYSSLSYA 156

  Fly   145 LAEIVQSFAWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGD--DHRPFLKEIKLSTD 207
            :.::||...|::.||||:....|.:||:::......:....::|| |.|  |.||.|||:|.|.:
Zfish   157 ILDLVQFLKWKTATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQL-PMDTVDTRPLLKEMKRSRE 220

  Fly   208 NCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTVRLMDPSDFH 272
            ..:|..|:.....:||:||..:.|:.||.......||..:|:.........|:|..|:::..:..
Zfish   221 FRIIFDCSHTMAAQILKQAQMMGMMTEYYHYIFTTLDLMAINLEPYRFCGVNMTGFRILNVDNPQ 285

  Fly   273 VKNVVHDWE-EREKREGRYFKVDPNRVKSQM----ILLNDAVWLFSKGLTELGIFEELTAPDLEC 332
            |.::|..|. ||:...    |.|...::..|    .|..|||.:.|......   .::|...|:|
Zfish   286 VASIVEKWSLERQIPP----KPDSGLLEGIMTTDAALTYDAVHIVSVSYQHA---PQMTVNSLQC 343

  Fly   333 RRKKPWPFGKRIIEFIKARSEETSTGRIDFNE-NGQRSFFTLRFMELNSDGFLDLATWDPVNGLD 396
            .|.|||.||.|.:.|||....:..|||:.||. .|.|:.|.|..:.|..||...:..|....||:
Zfish   344 HRHKPWRFGGRFMSFIKESHWDGLTGRLCFNRTTGLRTDFDLDIVSLKEDGLQKVGKWSASGGLN 408

  Fly   397 VLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLN 461
            :.....::...:...|||::.::::.|..|::.|::..:.  |.||.|:||:.|||:.|:|.:|.
Zfish   409 ITEVPRQNGMNITDSLSNRSLVITTILEEPYVMLKKSDKA--LVGNDRFEGFCIDLLKELASILG 471

  Fly   462 FKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISI 526
            |.:|..:.||||||..:...| |:|::|:|::..|||.:..||:|..|.:|:||:.||:..||||
Zfish   472 FSYEIHLVPDGKYGFQDDKGQ-WNGMIRELMEHRADLAVAPLTITFMREKAIDFSKPFLNTGISI 535

  Fly   527 LFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPCKEPEE-VENI 590
            |:.||.:..:..||||:|.:.|:|:|:..|||.:|.:||.:||.:|.:|.:.|||....: |||.
Zfish   536 LYRKPNSTNSGFFSFLNPMTPDIWVYILLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSDVVENN 600

  Fly   591 WSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINS 655
            ::::|:.|..:||||.||.:::|||.|||::.|:||||.|::::|||||||||||..|..:.::|
Zfish   601 FTLLNSFWFGVGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMDSPVDS 665

  Fly   656 AEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLY 720
            |:|||.|:||:||.:..|:||.||:.|..||::|||..|.|...:.|.|:.::|::||.|..  |
Zfish   666 ADDLAKQTKIEYGVVKDGATMSFFKKSRVSTFEKMWAFMSSRQSTSFVKSIEDGIQRVLKSD--Y 728

  Fly   721 AFLMESTTLEYNVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKW 785
            |.||||||:||...|.|:|.|:||.:|.|.|||..|..||||.:|:.|:|.:.|.|:|..||.||
Zfish   729 ALLMESTTIEYVTRRNCNLTQVGGIIDSKGYGIGTPKGSPYRDKITIAILGILEDGRLHMLKEKW 793

  Fly   786 WKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKISL 850
            |    .|.:|  .:::..:|..:|::|:||:|:||..||:.::.:...||::.::..|..|::.|
Zfish   794 W----SGSSC--LEDERYETGPMGIQNLGGIFIVLASGLVLSVFVAIGEFIYKLRKTAEREQVFL 852

  Fly   851 -------------KEAFKSEALFAARIWITTKPVHTSSESGSSNSSS-----SSSSRSKHSFKSQ 897
                         :|..:::|..||.         :.:|.|.|:..:     |.:.:.:|..:.:
Zfish   853 QCGDGRDQTVVHVRETGEAQAPPAAA---------SHAEDGRSDQHALLQRPSPARKGQHELQHR 908

  Fly   898 G---LSMKSLKSSGYQDVEASV 916
            .   :||..|.....:.|..:|
Zfish   909 DDARVSMTCLGDGHLRHVPGAV 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	123/388 (32%)
		ANF_receptor	39..379	CDD:279440	115/353 (33%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	169/373 (45%)
		Lig_chan	548..812	CDD:278489	121/264 (46%)
LOC100334689	XP_017206939.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591048
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60082
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100167
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.660