Protein Alignment clumsy and grin3bb

DIOPT Version :9

• Sequence 1: NP_001036373.1
• Gene: clumsy / 35394
• FlyBaseID: FBgn0026255
• Length: 1002
• Species: Drosophila melanogaster
• Sequence 2: XP_017213803.2
• Gene: grin3bb / 100333101
• ZFINID: ZDB-GENE-131122-77
• Length: 1114
• Species: Danio rerio
• Alignment Length: 1173
• Identity: 245/1173 - (20%)
• Similarity: 430/1173 - (36%)
• Gaps: 333/1173 - (28%)

  Fly     4 LFLTHFLLIALP---------VLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRA---------N 50
            :||.|.||:..|         :||.|..: ..:|::.   .....:..|.|:.||         |
Zfish    18 IFLLHTLLLLQPAHSHPQPCHILARIGHT-VRLGALL---PPRQSVRVRAALHRALSGLAESGNN 78

  Fly    51 ILERNVELVPIVVYANTDDSFIMEKMVC-NLISQGVIAIFG-PSTGSSSDIIASICDTLDIPHIV 113
            .|..|:.|..:...|.:.|...:.:.|| :::.|||.|:.. |.|......:..:...|:||.|.
Zfish    79 FLPYNLSLDVVAREAQSGDPESLFRCVCQDIVVQGVSAVLAFPQTQEEIVQMEFMSSFLEIPFIS 143

  Fly   114 YDWIPNESIP----DREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL 174
               |.....|    :|.|..||..:.|..|:  :.|..::|...|.....|.....|...|.|:|
Zfish   144 ---IIEHGEPLKTQNRFHLQMTTRIPPSGLV--ELLLAVLQRSGWEESMAVLCHGWEDAGLLDLL 203

  Fly   175 QVGEPIS--------------NPTTVKQLGPGD--------DHRPFLKEIKLSTDNCLILHCAPD 217
            ::.....              :.:|.:.....|        ||.|        ..:.|:....|:
Zfish   204 KLQGRFGWGPSQWHLRAALNLSHSTARMANISDFLSEHFNLDHSP--------PASVLLFGADPE 260

  Fly   218 NLLKILQQANELKM--------LGE------YQSVFIPLLDTHSIDFGELSGVEANITTVRLMDP 268
            ....:|:.|::|.:        :|.      ..|:.:||   ..:.:||:.           ..|
Zfish   261 CASSVLRSAHDLGLTLPTVHWIMGHPLSPDALHSIGLPL---GLLAYGEVD-----------HKP 311

  Fly   269 SDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAPDL--- 330
            .||::                                :||:.|.::.:|...:    ..|||
Zfish   312 LDFYI--------------------------------SDALQLINRAVTAATV----VRPDLALI 340

  Fly   331 ----EC-----RRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQR-------SFFTLRFMELN 379
                .|     :.:.| ..|:.|..|:...|....||.:....|..|       ..::||...:.
Zfish   341 QNMVNCFDKPNKHELP-SSGQYIARFLSNTSFVGLTGPVIVQRNLSRVHTSHKVHIWSLRRDAVG 404

  Fly   380 SDGFLDLATWDPVNGLDVLNDDEE-----------SEKRVGQK---------LSNKTFIVSSRLG 424
            ...::.:.:|:...    ||.:|:           :|.::|::         :|.....|.:.:.
Zfish   405 QPTWVTVGSWEGGR----LNVEEQGLWQGSSPRQRTEGQMGREGRRWRAGFPVSGSRLRVVTLVE 465

  Fly   425 APFLTLREPQE-------------------------GEILTGNSRY---------EGYSIDLINE 455
            .||:..||..|                         .|...||..:         .||.|||:.:
Zfish   466 HPFVFTREVDEDGNCPAGQYCLDAGTNSSETLDHLYAERAQGNKSFLPPDYSKCCYGYCIDLLEK 530

  Fly   456 IAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFM 520
            :::.:||:|:..:..||||||: |..| |.|:|..|:.|.||:.:...::.|:|.:.:|||.||.
Zfish   531 LSEDMNFEFDLYIVGDGKYGAV-KGGQ-WTGLVGDLLSGVADMAVTSFSINSARSKVIDFTSPFF 593

  Fly   521 TLGISILF-SKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDWENPHPC--- 581
            :..:.||. ||....|  :.:|:.|....:|  ||   :|::|.:.||. :...:|::|...
Zfish   594 STSLGILVRSKDTAAP--IGAFMWPLHWSMW--MG---IFVALHITALF-LTLYEWKSPFGMTPH 650

  Fly   582 -KEPEEVENIWSIMNTTWLSIGSLMGQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFL 644
             :...:|.:..|.:|   |....|.|:.... .||..:.|.:..:|..|.|::|:||||||||.:
Zfish   651 GRNRVKVFSYSSALN---LCYAILFGRTVSSKTPKCWTGRFLMNLWAIFCLLVLSSYTANLAAVM 712

  Fly   645 TNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTY-QKMWTAMESASPSVFTKTNDE 708
            ...:....::...|    :|:.:.:.  |...|..|:|:...| :|.:..|..........|..:
Zfish   713 VGEKTFEEVSGIHD----AKLHHPSQ--GFRFGTVRESSAEDYMKKSFPEMHEYMRKFNEPTTPD 771

  Fly   709 GVERVQKG-KNLYAFLMESTTLEY--NVERKCDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVL 770
            ||..::.. ..|.||:|:...|:|  :::..|.|:.:|.....:.|||.:|.|||....||..|.
Zfish   772 GVATLKTDPPQLDAFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNISEFVS 836

  Fly   771 KLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVGGVFLVLGLGLLSAMVLGCTEF 835
            :....|.:..|..||:|.:    .|.|......:|.::|:.:..|:|::|.:|:..|::....|.
Zfish   837 RYKSDGYMDMLHDKWYKVV----PCGKRVFAVTETLQMGIRHFSGLFVLLCVGVTGALLTLAGEH 897

  Fly   836 L---------------------------------------------------------------- 836
            .
Zfish   898 AFYRLVLPHIRRKQKFKYWLHTSQKIHRALNMTYEDVKRQRANTEKSCNIQKAQPHPPPQPAPLG 962

  Fly   837 ----WNVKS--VAIEEKISLKEAFKSEALFAARIW--ITTKPVHTSSESGSSNSSSSSSSR---S 890
                ||.:|  ||.|.|.:.:..|..|.|...|:.  :.:....|||.|..|:.:.|..:|   :
Zfish   963 SFARWNNESAKVAQEPKDNKRVHFNLETLNTRRLLPRVVSDGGQTSSASTLSSGAGSLLARVCEN 1027

  Fly   891 KHSFKSQGLSMKSLKSSGYQDVE--------------------ASVHSKLKKIGSMFSLKSQKTV 935
            ....:....|::|...||..::|                    |.:.:.|.|..:..:|.:..|.
Zfish  1028 GGPVQRATSSVRSSSPSGQDELEELQTKIEEIRGHLKAALARRAELQTTLAKERAAAALTTATTT 1092

  Fly   936 TPP 938
            .||
Zfish  1093 APP 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	78/439 (18%)
		ANF_receptor	39..379	CDD:279440	76/409 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	111/416 (27%)
		Lig_chan	548..812	CDD:278489	70/272 (26%)
grin3bb	XP_017213803.2	PBP1_iGluR_NMDA_NR3	29..428	CDD:107372	85/470 (18%)
		PBP2_iGluR_NMDA_Nr3	457..852	CDD:270438	110/413 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591058
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930