DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clumsy and LOC100331381

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_017207884.1	Gene:	LOC100331381 / 100331381	-ID:	-	Length:	1063	Species:	Danio rerio

Alignment Length:	941	Identity:	306/941 - (32%)
Similarity:	493/941 - (52%)	Gaps:	98/941 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAVDRANILE------RNVELVPIVVYANTD--- 68
            |||.|.......|:|..:..:....|::...:||..|.||:      |...|...:...|.:
Zfish     3 ALPALLLSIHLLFLVLLLTMAPSSHSQVPALSAVRMAAILDDQSACGRGERLALALARENINSLM 67

  Fly    69 ----------DSFIMEK--------MVCNLISQGVIAIFGP-STGSSSDIIASICDTLDIPHIVY 114
                      |.|.:::        .:|.::.:||:::.|| |:.:|...::.||...:||||..
Zfish    68 EGPARARVEVDIFELQRDSQYETTDTMCQILPKGVVSVIGPASSPASGSTVSHICGEKEIPHIKI 132

  Fly   115 DWIPNES--IPDREHSTMTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDILQVG 177
            .  |.|:  :|....:::||  :|.|..||..:..|::||.:.:.:::....:.|.:|::::: .
Zfish   133 G--PEETPRLPYLRFASVTL--YPSNEDLSLAIGAILRSFGYPTASLICAKAECLLRLEELVR-H 192

  Fly   178 EPISNPT-TVKQLGPGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIP 241
            ..||..| :|:.|....|..|.||||:......:|:.......:.||::|:||.|...:....:.
Zfish   193 FLISRETLSVRMLDENLDPTPLLKEIRDDKVATIIIDANASVSILILKKASELGMTSAFYKYILT 257

  Fly   242 LLDTHSIDFGELSGVEANITTVRLMDPS-----DFHVKNVVHDWEEREKREGRYFKVDPNRVKSQ 301
            .:|...:...::...::||....:::.|     :| ::::...|     |||......|....|.
Zfish   258 TMDFPLLRLDDVVNDQSNIVGFSMLNNSHPFYLEF-IRSLNLSW-----REGCDLSPYPGPALSS 316

  Fly   302 MILLNDAVWLFSKGLTELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENG 366
            .::. |||.:....:.||...:|:....|.|.....|..|..::.:::....:..|||::||..|
Zfish   317 ALMF-DAVHVVVGAVRELNRSQEIGVKPLSCTSSLIWQHGTSLMNYLRMVEYDGLTGRVEFNSKG 380

  Fly   367 QRSFFTLRFMELNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLR 431
            ||:.:|||.:|....|..::..|...|.|.:  :....:....:.|:|||..|::.|..|::..:
Zfish   381 QRTNYTLRILEKFKGGHKEIGVWYSNNTLAM--NSTSLDINTSETLANKTLTVTTILENPYVMRK 443

  Fly   432 EPQEGEILTGNSRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNA 496
            |..:.  ..|:.:|||:.:|::.|:|.:|.|.|..::..||.||| .:...:|.|:|.:||:..|
Zfish   444 ENYQD--FQGSDQYEGFCVDMLRELADILKFSFRIKLVDDGLYGA-PEPNGSWTGMVGELINRKA 505

  Fly   497 DLGICDLTMTSSRRQAVDFTPPFMTLGISILF-----SKPPTPPTDLFSFLSPFSLDVWIYMGSA 556
            ||.:...|:||.|.:.:||:.|||.||||||:     .||     ..||||.|||..||::|..|
Zfish   506 DLAVAGFTITSEREKVIDFSKPFMNLGISILYRVHIGRKP-----GYFSFLDPFSPAVWLFMLLA 565

  Fly   557 YLFISLLLFALARMAPDDWENPHPC--KEPEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTR 619
            ||.:|.:||..||::|.:|.||.||  :..:.:||.:::.|:.|..||..|.||.:|:|:|.|||
Zfish   566 YLAVSCVLFLAARLSPYEWYNPFPCWRERRDLLENQYTLGNSLWFPIGGFMQQGSEIMPRALSTR 630

  Fly   620 LVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNF 684
            .|:|:||.|.|::::|||||||||||..|....|.||||||.|:.|:||.:.|||||.||.:|.:
Zfish   631 CVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPIESAEDLADQTNIQYGTIQGGSTMTFFMNSRY 695

  Fly   685 STYQKMWTAMESASPSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERKCDLVQIGGWLDYK 749
            .|||:||..|.|..||||.|:.:||:.||...|  ||||:|||..||:....|:|.||||.||.|
Zfish   696 QTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSK--YAFLLESTMNEYHRRLNCNLTQIGGLLDTK 758

  Fly   750 SYGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGDTPELGLENVG 814
            .|||.||..||:|.:|:..:|:|.|..:|..|||:||:    ||.|.|  |:......||::|:|
Zfish   759 GYGIGMPLGSPFRDEITLGILQLQENNRLEILKRRWWE----GGKCLK--EEDHRAKGLGMDNIG 817

  Fly   815 GVFLVLGLGLLSAMVLGCTEFLWNVKSVAIEEKI-----------SLKEAFKSEALFAARIWITT 868
            |:|:||..||:.|:.:...||:|:.:..|..:::           ..:.:...|.:...|..|:.
Zfish   818 GIFVVLICGLIIAVFVAIMEFVWSTRRSAETDEVRPHPCPVRNHRHARVSVCQEMMTEFRNVISC 882

  Fly   869 KPVHTSSESGSSNSSSSSSSRSKHSFKSQGL 899
            |              .:|..|.:.:|.|||:
Zfish   883 K--------------KNSRLRRRRAFSSQGV 899

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	93/405 (23%)
		ANF_receptor	39..379	CDD:279440	88/375 (23%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	175/379 (46%)
		Lig_chan	548..812	CDD:278489	129/265 (49%)
LOC100331381	XP_017207884.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D60688at33208
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920