DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and gria3

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001106494.1	Gene:	gria3 / 100127683	XenbaseID:	XB-GENE-1010483	Length:	887	Species:	Xenopus tropicalis

Alignment Length:	851	Identity:	285/851 - (33%)
Similarity:	449/851 - (52%)	Gaps:	55/851 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDKDESEIAFRTAVDRANILERNVE----LVPIVVYANTDDSFIMEKMVCNLISQGVIA 87
            :|.:|..:..:...||..||...|..:.|.|    |...|.:.::.:||.:....|:..|:||.|
Frog    30 IGGLFMRNTIQEHSAFLFAVQLHNTNQNNTERPFQLFHHVDHLDSSNSFSVTNAFCSQFSRGVYA 94

  Fly    88 IFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQSF 152
            |||.....|.:.:.|.|..|....|      ..|.|........:.:.|.   |...:..::..:
Frog    95 IFGFYDQMSMNTLTSFCGALHTSFI------TPSFPTDADVQFVIQMRPP---LKGAILTLLNEY 150

  Fly   153 AWRSFTVVYETDKELQQLQDILQVGEPISNPTTVKQLGPGDDHRPF---LKEIKLSTDNCLILHC 214
            .|:.|..:|:|::....||.|::.....:...|.:.:|...|.:.|   ::|:....:...::.|
Frog   151 DWQKFVYLYDTERGFSILQAIMEAAVQNNWQVTARSVGNIKDVQEFKRIIEEMDRRQEKRFVIDC 215

  Fly   215 APDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGV---EANITTVRLMDPSDFHVKNV 276
            ..:.:..||:|   :.:||::...:..:|.........|..|   .||:|..::::..:..|:..
Frog   216 EVERINTILEQ---VVILGKHTRGYHYMLANLGFTGFTLERVMHGGANVTGFQIVNNENPIVQQF 277

  Fly   277 VHDW---EEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTEL-----GIFEELTAPDLECR 333
            :..|   :|||..|.|     ...:|....|.:|||.:.::....|     .:....:|.|....
Frog   278 LQRWVRLDEREFPEAR-----NTPLKYTSALTHDAVLVIAEAFRYLRRQRVDVSRRGSAGDCLAN 337

  Fly   334 RKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLATWDPVNGLDVL 398
            ...||..|..|...:|....:..||.|.|:..|:|:.:|:...|:.:.....:..|:........
Frog   338 PAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMTATKPRKVGHWNEYERFVPA 402

  Fly   399 NDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGNSRYEGYSIDLINEIAKMLNFK 463
            .|.:.:.:  ...:.|||.||::.|..|:  :.:.:..|:|.||.:||||.:||.:||||.:..|
Frog   403 PDQQPTNE--SSSVENKTIIVTTILENPY--VMKKKNHELLDGNDKYEGYCVDLASEIAKHVGIK 463

  Fly   464 FEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILF 528
            ::..:..||||||.:..|:.|:|:|.:|:.|.||:.:..||:|..|.:.:||:.|||:|||||:.
Frog   464 YKLSIVEDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMI 528

  Fly   529 SKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAPDDW--ENPHPCKEPE---EVE 588
            .||......:||||.|.:.::|:.:..||:.:|::||.::|.:|.:|  |:....::|:   :..
Frog   529 KKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDTDEARDPQNPPDPP 593

  Fly   589 NIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSI 653
            |.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|::::|||||||||||..|..:.|
Frog   594 NEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPI 658

  Fly   654 NSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVERVQKGKN 718
            .||||||.|::|.||.:..|||..|||.|..:.|:|||:.|:||.|||||||.|:||.||:|.|.
Frog   659 ESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTDDGVARVRKSKG 723

  Fly   719 LYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYRKQISAAVLKLGELGQLAELK 782
            .:|||:|||..||..:|| ||.:::||.||.|.||:|.|..|.....::.|||||.|.|.|.:||
Frog   724 KFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGTPVNLAVLKLSEQGILDKLK 788

  Fly   783 RKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGLLSAMVLGCTEFLWNVKSVAI 844
            .|||   :..|.|...|....| |..|.|.||.|||.:|  ||||  ||::...||.:  ||.|.
Frog   789 NKWW---YDKGECGAKDSGSKDKTSALSLSNVAGVFYILVGGLGL--AMMVALIEFCY--KSRAE 846

  Fly   845 EEKISL 850
            .:::.|
Frog   847 SKRMKL 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	83/386 (22%)
		ANF_receptor	39..379	CDD:279440	80/357 (22%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	175/378 (46%)
		Lig_chan	548..812	CDD:278489	126/270 (47%)
gria3	NP_001106494.1	Periplasmic_Binding_Protein_Type_1	29..400	CDD:324556	83/386 (22%)
gria3	NP_001106494.1	PBP2_iGluR_AMPA	416..798	CDD:270433	177/386 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.100