DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and gria4

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	XP_031751480.1	Gene:	gria4 / 100125052	XenbaseID:	XB-GENE-5838893	Length:	902	Species:	Xenopus tropicalis

Alignment Length:	910	Identity:	312/910 - (34%)
Similarity:	474/910 - (52%)	Gaps:	71/910 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LFLTHFLLIALPVLADIDRSQFMVGSIFTSDKDESEIAFRTAV----DRANILERNVELVPIVVY 64
            ||.:.|..:|:....    |...:|.:|..:.|:...|||.|:    ...|..|....|||.|..
Frog    10 LFFSGFWGLAMGAFP----SSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNESEALFNLVPHVDN 70

  Fly    65 ANTDDSFIMEKMVCNLISQGVIAIFGPSTGSSSDIIASICDTLDIPHIVYDWIPNESIPDREHST 129
            ..|.:||.:....|:..|:||.||||.....|...:.|.|..|.|..|      ..|.|....|.
Frog    71 IETSNSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLI------TPSFPTEGESQ 129

  Fly   130 MTLNVHPDNLLLSQGLAEIVQSFAWRSFTVVYETDKELQQLQDIL----QVGEPISNPTTVKQLG 190
            ..|.:.|.   |...|..::..:.|..:..:|:||:....||.|:    |.|..:| ...|:...
Frog   130 FVLQLRPS---LRGALLSLLDHYGWNHYVFLYDTDRGYSILQAIMEKAGQNGWQVS-AICVENFN 190

  Fly   191 PGDDHRPFLKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVF---IPLLDTHSIDFGE 252
            .. .:|..|:::....:|..::.|..:.|..||:|   :..:|::...:   |..|....|....
Frog   191 DA-SYRRLLEDLDRRQENKFVIDCEVERLQNILEQ---IVSVGKHVKGYHYIIANLGFKDISLDR 251

  Fly   253 LSGVEANITTVRLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGL- 316
            .....||:|..:|:|.:...|..::..|:..::||   :....:..|....|..|.|.:.::..
Frog   252 FMHGGANVTGFQLVDFNTPIVTELMQRWKTLDQRE---YPGSESPPKYTSALTYDGVLVMAEAFR 313

  Fly   317 ----TELGIFEELTAPDLECRRKKPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFME 377
                .::.:.....|.|.......||..|..:...:|....:..||.|.|:..|:|..:|:..:|
Frog   314 ILRRQKIDLSRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNIQFDHYGRRVNYTMDVLE 378

  Fly   378 LNSDGFLDLATWDPVNGLDVLNDDEESEKRVGQKLSNKTFIVSSRLGAPFLTLREPQEGEILTGN 442
            |.|:|...:..|:.::.| ||...|.:.|.....:.|:|.||::.|.||::..:  :..|:|.||
Frog   379 LKSNGLRKIGYWNDMDKL-VLLQHEPAFKNDSSGIENRTVIVTTILEAPYVMYK--KNHELLEGN 440

  Fly   443 SRYEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNKVTQTWDGIVRQLIDGNADLGICDLTMTS 507
            .::|||.:||..||||.:..|::..:.|||||||.:..|:.|:|:|.:|:.|.|::.:..||:|.
Frog   441 DKFEGYCVDLAYEIAKHIGIKYKIAIVPDGKYGARDSETKIWNGMVGELVYGKAEIAVAPLTITL 505

  Fly   508 SRRQAVDFTPPFMTLGISILFSKPPTPPTDLFSFLSPFSLDVWIYMGSAYLFISLLLFALARMAP 572
            .|.:.:||:.|||:|||||:..||......:||||.|.:.::|:.:..||:.:|::||.::|.:|
Frog   506 VREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSP 570

  Fly   573 DDW--ENPHPCKE--PEEVENIWSIMNTTWLSIGSLMGQGCDILPKAASTRLVTGMWWFFALMML 633
            .:|  |.|...||  .::..|.:.|.|:.|.|:|:.|.|||||.|::.|.|:|.|:||||.|:::
Frog   571 YEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIII 635

  Fly   634 NSYTANLAAFLTNSRQANSINSAEDLAAQSKIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESAS 698
            :|||||||||||..|..:.|.||||||.|::|.||.:..|||..||:.|..:.|:||||.|:||.
Frog   636 SSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDAGSTKEFFKRSKIAVYEKMWTYMKSAE 700

  Fly   699 PSVFTKTNDEGVERVQKGKNLYAFLMESTTLEYNVERK-CDLVQIGGWLDYKSYGIAMPFNSPYR 762
            |||||||..|||.||:|.|..:|||:|||..||..:|| ||.:::||.||.|.||:|.|.:|..|
Frog   701 PSVFTKTTAEGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKHSQLR 765

  Fly   763 KQISAAVLKLGELGQLAELKRKWWKEMHGGGNCEKSDEDGGD-TPELGLENVGGVFLVL--GLGL 824
            ..::.|||||.|.|.|.:||.|||   :..|.|.....|..| |..|.|.||.|||.:|  ||||
Frog   766 NAVNLAVLKLNEQGLLDKLKNKWW---YDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGL 827

  Fly   825 LSAMVLGCTEFLWNVKSVAIEEKISLKEAFKSEALFAARIWIT--------------TKPVHTSS 875
              ||::...||.:..::.|...|::..||.:::    ||:.||              .|.|||.:
Frog   828 --AMLVALIEFCYKSRAEAKRMKLTFSEAIRNK----ARLSITGSIGENGRVLTPDCPKAVHTGT 886

Fly 876 875
Frog 887 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	91/385 (24%)
		ANF_receptor	39..379	CDD:279440	84/355 (24%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	177/377 (47%)
		Lig_chan	548..812	CDD:278489	129/269 (48%)
gria4	XP_031751480.1	PBP1_iGluR_AMPA_GluR4	28..400	CDD:380611	94/389 (24%)
gria4	XP_031751480.1	PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	179/385 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000021
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18966
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.100