DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clumsy and grin2ca

DIOPT Version :9

Sequence 1:	NP_001036373.1	Gene:	clumsy / 35394	FlyBaseID:	FBgn0026255	Length:	1002	Species:	Drosophila melanogaster
Sequence 2:	NP_001352716.1	Gene:	grin2ca / 100003342	ZFINID:	ZDB-GENE-070822-3	Length:	1400	Species:	Danio rerio

Alignment Length:	1091	Identity:	243/1091 - (22%)
Similarity:	436/1091 - (39%)	Gaps:	216/1091 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VGSIFTSDKDESEIAFRTAVDRANILERNVELVPIVVYANTDDSFIMEKMVCNLISQGVI--AIF 89
            |..:|:....::||..|  :.|.|.|:..:|:.||.|..|..:...:...:|:.::...:  .:|
Zfish    42 VAVVFSGSAYQTEIKGR--LSRENFLDLPLEVNPITVLVNNTNPRTLLTRICDTLAANRVHGVVF 104

  Fly    90 GPSTGSSSDIIASICDTLD----IPHIVYDWIPNESIPDREHSTMTLNVHPDNLLLSQGLAEIVQ 150
            ..:.|  |:.:|.|.|.:.    :|.:.........:|.:...:..|.:.........|:.::::
Zfish   105 EDNIG--SEAVAQILDFISTQTAVPIVGISGGSAVVLPHKGDGSTFLQLGSSIEQQINGMFKVME 167

  Fly   151 SFAWRSFTVV------YETDKE-----------LQQLQDILQVGEPISNPTTVKQLGPGDDHRPF 198
            .:.|.||.||      |:|..:           |.:|||.|...........::.       |..
Zfish   168 EYNWDSFVVVTSLYPGYDTYVDYIRSFIDTSYFLWELQDTLTFDMSADGMNDLRA-------RRL 225

  Fly   199 LKEIKLSTDNCLILHCAPDNLLKILQQANELKMLGEYQSVFIPLLDTHSIDFGELSGVEANITTV 263
            |::|....   |:::|:.|....:...|.|:.::|.....|||.|               .:...
Zfish   226 LQQIDAQV---LLVYCSHDEAQYLFSMAREVGLVGPGYIWFIPSL---------------AVGNP 272

  Fly   264 RLMDPSDFHVKNVVHDWEEREKREGRYFKVDPNRVKSQMILLNDAVWLFSKGLTELGIFEELTAP 328
            .:..|..|.| .::....:|.|...|      |||:..:.::...|..|.|   :.|..     |
Zfish   273 NIAPPDSFPV-GLISIITDRWKMSLR------NRVRDGVAIVVKGVESFRK---QRGFI-----P 322

  Fly   329 D--LECRRK-KPWPFGKRIIEFIKARSEETSTGRIDFNENGQRSFFTLRFMELNSDGFLDLAT-- 388
            |  ::|... :|...|......:....|.|     ||:              .||||:|...:
Zfish   323 DGHMDCLSPIRPASNGTLYRHMLNVSWENT-----DFS--------------FNSDGYLVNPSMI 368

  Fly   389 ---------WDPVNGLD--VLNDDEESEKRVGQKL----SNKTFIVSSRLGAPFLTL-------- 430
                     ||.|...:  :|........|.|..|    .|:...|::....||:.:
Zfish   369 IITLDRGRQWDKVGNYESGILQMRYPVWPRYGTFLEPVSDNRHLTVATLEERPFVIVEAVDPVTG 433

  Fly   431 ----------REPQEGEILTGNSR------YEGYSIDLINEIAKMLNFKFEFRMSPDGKYGALNK 479
                      |:..:.|.:.|::.      .:|:.||::.::::.:.|.::..:..:||:|.|
Zfish   434 TCLSNTVPCRRQSNKTETIVGHTEPYTKLCCKGFCIDILKKLSRNIKFSYDLYLVTNGKHGKL-- 496

  Fly   480 VTQTWDGIVRQLIDGNADLGICDLTMTSSRRQAVDFTPPFMTLGISILF--SKPPTPPTDLFSFL 542
            |...|:|::.::....||:.|..||:...|.:.:||:.||:..|||::.  |.....|:   :||
Zfish   497 VRGIWNGMIGEVFYKRADMAIGSLTINEERSEIIDFSVPFVETGISVMVARSNGTVSPS---AFL 558

  Fly   543 SPFSLDVWIYMGSAYL-FISLLLFALARMAPDDWENP-HPCKEPEEVENIWSIMNTTWLSIGSLM 605
            .|:|..||:.|....| .:::.:|.....:|..:... ...|:|.  ...::|..:.||..|.:.
Zfish   559 EPYSPAVWVMMFVMCLTVVAVTVFVFEYCSPVGYNRSLVSAKDPG--GPTFTIGKSVWLLWGIVF 621

  Fly   606 GQGCDI-LPKAASTRLVTGMWWFFALMMLNSYTANLAAFLTNSRQANSINSAEDLAAQS------ 663
            .....| .||..:::::..:|.|||::.|.|||||||||:...:..::::...|...|.
Zfish   622 NNSVPIENPKGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQKPQDQYP 686

  Fly   664 KIKYGAMAGGSTMGFFRDSNFSTYQKMWTAMESASPSVFTKTNDEGVE----RVQKGKNLYAFLM 724
            ..::|.:..|||....|    |.|.:|.:.|        .|.|.:|||    .::.|| |.||:.
Zfish   687 PFRFGTVPNGSTERNIR----SNYPEMHSHM--------VKYNQKGVEDALNSLKTGK-LDAFIY 738

  Fly   725 ESTTLEY--NVERKCDLVQIGGWLDYKS--YGIAMPFNSPYRKQISAAVLKLGELGQLAELKRKW 785
            ::..|.|  ..:..|.||.||....:.:  ||||:...|.:::.|..|:|:....|...:|:..|
Zfish   739 DAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIALQKESRWKRPIDLALLQFLADGDTQKLQTVW 803

  Fly   786 WKEMHGGGNCEKSDEDGGDTPELGLENVGGVF--LVLGLGLLSAMVLGCTEFL-WNVK-SVAIEE 846
            ..     |.| ::::....:.:|.::|:.|||  |::.:| ||.:|......| |.:: ||...|
Zfish   804 LT-----GIC-RNEKKEVMSSKLDIDNMAGVFYMLLVAMG-LSLLVFAWEHLLYWKLRHSVRKSE 861

  Fly   847 KISLKEAFKSEALFAARIWITTKPVHTSSESGSSNSSSSSSSRSKHSFKSQGLSMKSLKSSGYQD 911
            ::....|      .:..|:.....|..:...|:..:...::|.::.:......:.|.:.||.  .
Zfish   862 RLDFLLA------ISRGIYSCFNGVEDTDRKGNMQNPDVTTSYTQANMLKMLQTAKDIVSSA--R 918

  Fly   912 VEASVHSKLKKI--GSMFSLKSQKTVTPPPEIGWKLDKSTQIDVVPTSD--------VD---QEL 963
            ||.|:.:..|.|  .|....:|.:|..||..||..........:...:|        ||   |.|
Zfish   919 VENSLDNATKTIENWSRRDPESGRTSLPPCLIGTDFSHGRLPCIASVTDNHSPYPQNVDSTTQHL 983

  Fly   964 IPEVEPH-----------LPHRHHHHHHHRHHHHHHQPDQEH--DRNPSPP 1001
            :.  :||           ||.|..|||.:............|  .|:|.||
Zfish   984 LE--KPHVGTRPTSLRYTLPARTSHHHIYERTLPISSLSSPHIAIRDPPPP 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clumsy	NP_001036373.1	PBP1_iGluR_Kainate	26..396	CDD:107377	79/405 (20%)
		ANF_receptor	39..379	CDD:279440	69/365 (19%)
		PBP2_iGluR_Kainate	414..787	CDD:270432	105/415 (25%)
		Lig_chan	548..812	CDD:278489	71/280 (25%)
grin2ca	NP_001352716.1	PBP1_iGluR_NMDA_NR2	38..398	CDD:107373	80/418 (19%)
		PBP2_iGluR_NMDA_Nr2	409..810	CDD:270436	107/426 (25%)
		NMDAR2_C	847..>938	CDD:313729	19/98 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591067
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1052
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830