DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31624 and FHL3

DIOPT Version :9

Sequence 1:	NP_001163031.1	Gene:	CG31624 / 35393	FlyBaseID:	FBgn0051624	Length:	178	Species:	Drosophila melanogaster
Sequence 2:	NP_004459.2	Gene:	FHL3 / 2275	HGNCID:	3704	Length:	280	Species:	Homo sapiens

Alignment Length:	174	Identity:	60/174 - (34%)
Similarity:	87/174 - (50%)	Gaps:	5/174 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CHKCQEAI--TKRMITALGKTWHPEHFLCHHCDEQILDATFNVQSGEPVCNKCFVERYTYTCAGC 69
            |.:||:.|  ..|.:....:.:|...|.|..|...:.|..|..|..|.:||.|:...::..|:.|
Human    40 CAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSAC 104

  Fly    70 KKPIL--EKTICAMGERWHEACFCCGGACKKPLASQTFYERDGKPYCKQDYENLFAARCAKCEKP 132
            .:.::  .:.:...|:.|||.||.|.| |::||.|::|....|..||...|||.||.|||:|.|.
Human   105 GETVMPGSRKLEYGGQTWHEHCFLCSG-CEQPLGSRSFVPDKGAHYCVPCYENKFAPRCARCSKT 168

  Fly   133 ITDSAVLAMNVKWHRNCFQCNKCENPITSQTFTIDGDKPVCPAC 176
            :|...|...:..|||.|..|..|:.|:..|.||...:.|.|.||
Human   169 LTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVAC 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31624	NP_001163031.1	LIM	7..58	CDD:351770	15/52 (29%)
		LIM	66..118	CDD:351770	18/53 (34%)
		LIM	125..176	CDD:214528	19/50 (38%)
FHL3	NP_004459.2	LIM	<5..33	CDD:295319
		LIM1_FHL3	36..94	CDD:188807	16/53 (30%)
		LIM2_FHL3	98..155	CDD:188811	18/57 (32%)
		LIM3_FHL	162..213	CDD:188732	20/51 (39%)
		LIM4_FHL3	221..276	CDD:188818
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	129	1.000	Inparanoid score	I4662
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104605
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.820