DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31624 and SYNPO2

DIOPT Version :10

Sequence 1:NP_724318.1 Gene:CG31624 / 35393 FlyBaseID:FBgn0051624 Length:178 Species:Drosophila melanogaster
Sequence 2:NP_597734.2 Gene:SYNPO2 / 171024 HGNCID:17732 Length:1261 Species:Homo sapiens


Alignment Length:16 Identity:8/16 - (50%)
Similarity:11/16 - (68%) Gaps:0/16 - (0%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 LFAARCAKCEKPITDS 136
            |||.|.::.||.:.||
Human   875 LFAKRQSRMEKYVVDS 890

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31624NP_724318.1 LIM 7..58 CDD:413332
LIM 66..118 CDD:413332
LIM 125..176 CDD:214528 5/12 (42%)
SYNPO2NP_597734.2 Interaction with VPS18. /evidence=ECO:0000269|PubMed:23434281 1..180
PDZ_SYNPO2-like 8..85 CDD:467264
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..174
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..233
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 329..369
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:Q91YE8 398..406
Interaction with ACTN2. /evidence=ECO:0000269|PubMed:20554076 481..663
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..803
F-actin binding. /evidence=ECO:0000269|PubMed:23225103 534..663
PHA03247 <593..1070 CDD:223021 8/16 (50%)
Interaction with YWHAB. /evidence=ECO:0000250|UniProtKB:Q91YE8 607..811
Interaction with BAG3. /evidence=ECO:0000269|PubMed:23434281 615..626
PPPY motif. /evidence=ECO:0000305|PubMed:23434281 619..622
Interaction with ACTN2. /evidence=ECO:0000269|PubMed:20554076 664..924 8/16 (50%)
F-actin bundling activity. /evidence=ECO:0000269|PubMed:23225103 664..916 8/16 (50%)
F-actin binding. /evidence=ECO:0000269|PubMed:23225103 664..803
Actin binding. /evidence=ECO:0000250|UniProtKB:Q91YE8 751..900 8/16 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 834..870
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 937..956
Interaction with ZYX. /evidence=ECO:0000269|PubMed:16885336 1000..1019
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1041..1064
Blue background indicates that the domain is not in the aligned region.

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