DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm10 and Mcm10

DIOPT Version :9

Sequence 1:	NP_610097.2	Gene:	Mcm10 / 35390	FlyBaseID:	FBgn0032929	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001292188.1	Gene:	Mcm10 / 70024	MGIID:	1917274	Length:	885	Species:	Mus musculus

Alignment Length:	863	Identity:	249/863 - (28%)
Similarity:	398/863 - (46%)	Gaps:	146/863 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 SGTDISIDDEEEILALEKLLGAAENENTKSAESEKAKPTAPILVP---KLREDNSFANAFTFEKI 68
            ||.:....::||.||  .|.|..|:.......:.|...:.|...|   |..|:.........|::
Mouse    61 SGEEGKTGNQEERLA--TLFGDVEDLTDDEVATSKVGNSGPPPAPSQEKTSEELQDELKKLQEQM 123

  Fly    69 VKPEKQKNAAIIKEP----ELDSSDDEEVKNFLERKYNEYGSDINKRLKQQQENAYESKVAREVD 129
            ...::|..||.||:|    .|....|..::..|:          .||:::.||:|..|   .|:|
Mouse   124 KSLQEQLKAASIKQPPGTAPLQEPPDSSLQPLLK----------EKRIRRIQESACFS---AELD 175

  Fly   130 -QELKKSIHVVTSTPQP------LKNPHNPIKRQSAVSTTFQRPPPVAAAVASTSQSSAP----- 182
             ..|.|:..|......|      ::.|..|::    ||::|..|..     :|:|:||.|
Mouse   176 VPTLPKAKRVARKPKTPAESSSRMRTPAQPLQ----VSSSFLEPNH-----SSSSRSSTPSPQAV 231

  Fly   183 --------------------------VSAVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGV 221
                                      ||.|..:...|||:..|.|||:.:..:|.|||.:....:
Mouse   232 PGNKCSRTIRNQNTVSPGNSGDRPQQVSQVSVEAFSGLRLRRPRVSSTEMSRKMAGRKLIRLPQI 296

  Fly   222 AYHIERGDLAK-DWVIAGALVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKT 285
            ...:...:|.: |||..|.::.|...::...|..:|.|||:||....:.:|||||.:.||.||||
Mouse   297 KEKMATENLEETDWVTFGVILRKVTPQSATSGQTFSIWKLNDLHDLTQCVSLFLFGDVHKDLWKT 361

  Fly   286 AEGLCLAVLNPTIFERRAGSSDVACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDC 350
            .:|..:.:||....:.:.|..:| |||||..|||:|:|::.|||.|:|.||||:.||..|||.||
Mouse   362 EQGTVIGLLNANPMKPKDGLKEV-CLSIDHPQKVLIMGEAMDLGACKAKKKNGEPCTQTVNLHDC 425

  Fly   351 DYCIFHVKQEYGKMS-RRSELQSATAGRGI-------NELRNKVLGKNEVFYGGQTFTAVPARKS 407
            :||.:|::.:|.|:| :|::|||..:|..|       ..|:.: |.::..:|||.:..:..|.::
Mouse   426 EYCQYHIQAQYKKLSAKRTDLQSTFSGGRIPKKFRKGTSLKER-LCQDGFYYGGVSSESFAASRA 489

  Fly   408 AKLITKERDRLSM----LAGYDVSPFAHTANHTSKPKTAEPTK-------------IP-YAERGG 454
            |.:..|::.:.::    :.|      .::....:|.|...|.|             :| :..|..
Mouse   490 AAIAPKKKVQTTLTNLVVRG------TNSIIQETKQKLGIPQKSLSCSEEFRELMALPTFGARNL 548

  Fly   455 PVSRLAGGVEASRKQRVQDLERLRLLKEENER-FEKKKQAEGHVLGSDNKKESEAGTPAVSMPTT 518
            ...........|.|..:|.:....|||::.:: .|.:|:....:.....:..||..:|||...:.
Mouse   549 QKHLARAKASGSSKPAIQSISASALLKQQKQQMLEMRKRRSEDIQKRFLQSSSEVQSPAVPSSSR 613

  Fly   519 PVPDKFKNRGFSF---DASLTPKL--------SGSENFSFEINVGSR-----QAQNAKLKAAALL 567
            ....:....|..|   :.:.||::        .|.:...|:.:...|     .|:..||.|.|.|
Mouse   614 QAAAQSPRTGAEFPRLEGTATPRMPKLGRGISEGDDVLFFDDSPPPRPKLSAAAEAKKLAAIAKL 678

  Fly   568 KKKP--LEKINPNST-RGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSR---------- 619
            :.|.  |.|::||:| |....|  ||:..:.|:..:|  .....|::.|..||.|
Mouse   679 RAKGQILTKVDPNNTVRKQMDG--RAMLGVKERVENS--NTVSPEEELEPARKKRREQLAYLESE 739

  Fly   620 -IEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSAS 683
             .:||:.|.|.||::::..|.|.|:.||..|.:||.|||||..|.::.|:.|.|:.|.||.|...
Mouse   740 EFQKILKAKSKHTDILKEAEAELQKSYFEPLVKKEQMEEKMRATREVKCRVVTCRTCTYTHFKPL 804

  Fly   684 DRCKEQKHPLKVVDAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREK---KILTG 745
            :.|..::|.|...|..||||:| .|||||.::.|||.:.|:||...:|:|..|::||   ||  |
Mouse   805 ETCVSEQHNLHWHDGVKRFFKC-PCGNRTISLDKLPNKHCRNCGLYKWERDGMLKEKTGPKI--G 866

  Fly   746 RETLSVRGDEET-FMGCL 762
            .|||..||:|.. |:..|
Mouse   867 GETLLPRGEEHAKFLNSL 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm10	NP_610097.2	zf-primase	323..367	CDD:286419	23/44 (52%)
Mcm10	NP_610097.2	Mcm10	468..756	CDD:286422	102/321 (32%)
Mcm10	NP_001292188.1	N-terminal domain. /evidence=ECO:0000250	1..153		24/98 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..260		57/243 (23%)
		OB-fold domain. /evidence=ECO:0000250	251..405		62/154 (40%)
		zf-primase	398..443	CDD:401317	19/52 (37%)
		Zinc finger-like 1	406..431		10/25 (40%)
		Mcm10	544..883	CDD:401320	99/307 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..642		21/81 (26%)
		Zinc finger-like 2. /evidence=ECO:0000250	793..812		11/22 (50%)
		Zinc finger-like 3. /evidence=ECO:0000250	826..846

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839836
Domainoid	1	1.000	131	1.000	Domainoid score	I5147
eggNOG	1	0.900	-	-		E1_KOG3056
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41275
Inparanoid	1	1.050	285	1.000	Inparanoid score	I2833
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46518
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004424
OrthoInspector	1	1.000	-	-		oto95044
orthoMCL	1	0.900	-	-		OOG6_104520
Panther	1	1.100	-	-	LDO	PTHR13454
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R691
SonicParanoid	1	1.000	-	-		X5568
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790