Protein Alignment Mcm10 and Mcm10

DIOPT Version :10

• Sequence 1: NP_610097.2
• Gene: Mcm10 / 35390
• FlyBaseID: FBgn0032929
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_081566.2
• Gene: Mcm10 / 70024
• MGIID: 1917274
• Length: 885
• Species: Mus musculus
• Alignment Length: 863
• Identity: 249/863 - (28%)
• Similarity: 398/863 - (46%)
• Gaps: 146/863 - (16%)

  Fly     7 SGTDISIDDEEEILALEKLLGAAENENTKSAESEKAKPTAPILVP---KLREDNSFANAFTFEKI 68
            ||.:....::||.||  .|.|..|:.......:.|...:.|...|   |..|:.........|::
Mouse    61 SGEEGKTGNQEERLA--TLFGDVEDLTDDEVATSKVGNSGPPPAPSQEKTSEELQDELKKLQEQM 123

  Fly    69 VKPEKQKNAAIIKEP----ELDSSDDEEVKNFLERKYNEYGSDINKRLKQQQENAYESKVAREVD 129
            ...::|..||.||:|    .|....|..::..|:          .||:::.||:|..|   .|:|
Mouse   124 KSLQEQLKAASIKQPPGTAPLQEPPDSSLQPLLK----------EKRIRRIQESACFS---AELD 175

  Fly   130 -QELKKSIHVVTSTPQP------LKNPHNPIKRQSAVSTTFQRPPPVAAAVASTSQSSAP----- 182
             ..|.|:..|......|      ::.|..|::    ||::|..|..     :|:|:||.|
Mouse   176 VPTLPKAKRVARKPKTPAESSSRMRTPAQPLQ----VSSSFLEPNH-----SSSSRSSTPSPQAV 231

  Fly   183 --------------------------VSAVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGV 221
                                      ||.|..:...|||:..|.|||:.:..:|.|||.:....:
Mouse   232 PGNKCSRTIRNQNTVSPGNSGDRPQQVSQVSVEAFSGLRLRRPRVSSTEMSRKMAGRKLIRLPQI 296

  Fly   222 AYHIERGDLAK-DWVIAGALVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKT 285
            ...:...:|.: |||..|.::.|...::...|..:|.|||:||....:.:|||||.:.||.||||
Mouse   297 KEKMATENLEETDWVTFGVILRKVTPQSATSGQTFSIWKLNDLHDLTQCVSLFLFGDVHKDLWKT 361

  Fly   286 AEGLCLAVLNPTIFERRAGSSDVACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDC 350
            .:|..:.:||....:.:.|..:| |||||..|||:|:|::.|||.|:|.||||:.||..|||.||
Mouse   362 EQGTVIGLLNANPMKPKDGLKEV-CLSIDHPQKVLIMGEAMDLGACKAKKKNGEPCTQTVNLHDC 425

  Fly   351 DYCIFHVKQEYGKMS-RRSELQSATAGRGI-------NELRNKVLGKNEVFYGGQTFTAVPARKS 407
            :||.:|::.:|.|:| :|::|||..:|..|       ..|:.: |.::..:|||.:..:..|.::
Mouse   426 EYCQYHIQAQYKKLSAKRTDLQSTFSGGRIPKKFRKGTSLKER-LCQDGFYYGGVSSESFAASRA 489

  Fly   408 AKLITKERDRLSM----LAGYDVSPFAHTANHTSKPKTAEPTK-------------IP-YAERGG 454
            |.:..|::.:.::    :.|      .::....:|.|...|.|             :| :..|..
Mouse   490 AAIAPKKKVQTTLTNLVVRG------TNSIIQETKQKLGIPQKSLSCSEEFRELMALPTFGARNL 548

  Fly   455 PVSRLAGGVEASRKQRVQDLERLRLLKEENER-FEKKKQAEGHVLGSDNKKESEAGTPAVSMPTT 518
            ...........|.|..:|.:....|||::.:: .|.:|:....:.....:..||..:|||...:.
Mouse   549 QKHLARAKASGSSKPAIQSISASALLKQQKQQMLEMRKRRSEDIQKRFLQSSSEVQSPAVPSSSR 613

  Fly   519 PVPDKFKNRGFSF---DASLTPKL--------SGSENFSFEINVGSR-----QAQNAKLKAAALL 567
            ....:....|..|   :.:.||::        .|.:...|:.:...|     .|:..||.|.|.|
Mouse   614 QAAAQSPRTGAEFPRLEGTATPRMPKLGRGISEGDDVLFFDDSPPPRPKLSAAAEAKKLAAIAKL 678

  Fly   568 KKKP--LEKINPNST-RGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSR---------- 619
            :.|.  |.|::||:| |....|  ||:..:.|:..:|  .....|::.|..||.|
Mouse   679 RAKGQILTKVDPNNTVRKQMDG--RAMLGVKERVENS--NTVSPEEELEPARKKRREQLAYLESE 739

  Fly   620 -IEKIMAATSSHTNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSAS 683
             .:||:.|.|.||::::..|.|.|:.||..|.:||.|||||..|.::.|:.|.|:.|.||.|...
Mouse   740 EFQKILKAKSKHTDILKEAEAELQKSYFEPLVKKEQMEEKMRATREVKCRVVTCRTCTYTHFKPL 804

  Fly   684 DRCKEQKHPLKVVDAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREK---KILTG 745
            :.|..::|.|...|..||||:| .|||||.::.|||.:.|:||...:|:|..|::||   ||  |
Mouse   805 ETCVSEQHNLHWHDGVKRFFKC-PCGNRTISLDKLPNKHCRNCGLYKWERDGMLKEKTGPKI--G 866

  Fly   746 RETLSVRGDEET-FMGCL 762
            .|||..||:|.. |:..|
Mouse   867 GETLLPRGEEHAKFLNSL 884

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm10	NP_610097.2	zf-primase	323..365	CDD:462758	22/41 (54%)
		Mcm10	462..755	CDD:462760	103/326 (32%)
Mcm10	NP_081566.2	N-terminal domain. /evidence=ECO:0000250	1..153		24/98 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	23..260		57/243 (23%)
		OB-fold domain. /evidence=ECO:0000250	251..405		62/154 (40%)
		zf-primase	398..443	CDD:462758	19/52 (37%)
		Zinc finger-like 1	406..431		10/25 (40%)
		Mcm10	539..883	CDD:462760	100/313 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	579..642		21/81 (26%)
		Zinc finger-like 2. /evidence=ECO:0000250	793..812		11/22 (50%)
		Zinc finger-like 3. /evidence=ECO:0000250	826..846