DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm10 and mcm10

DIOPT Version :9

Sequence 1:	NP_610097.2	Gene:	Mcm10 / 35390	FlyBaseID:	FBgn0032929	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001019984.1	Gene:	mcm10 / 553396	ZFINID:	ZDB-GENE-041210-42	Length:	833	Species:	Danio rerio

Alignment Length:	834	Identity:	244/834 - (29%)
Similarity:	392/834 - (47%)	Gaps:	113/834 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PAQKSGTDISID---DEEEILALEKLLGAAENENTKSAESEKAKP--TAPILVPKLREDNSFANA 62
            ||.:.|.| ::|   ||::  ..|:.:...|.|..|..|.|:..|  ::...:.|.:||......
Zfish    25 PAAEEGED-NLDDLFDEDD--DGEQYIEPEEAEEEKEEEEEEVSPGKSSSSDLNKSKEDLEAELK 86

  Fly    63 FTFEKIVKPEKQKNAAIIKEPELD------------SSDDEEVKNFLERKYNEYG--SDINKRLK 113
            ...||:.|.::|..|:....|..:            :|....||.......:..|  |:|..:||
Zfish    87 LMQEKMQKLQQQLEASQKTTPAQNKPAVQRQSTKSLTSPQAGVKTTPPTVRDSDGSPSNITAKLK 151

  Fly   114 QQQENAYESKVAREVDQELKKSIHVVTSTPQPLKNPHNPIKRQSAVSTTFQRPPPVAAAVASTSQ 178
            .:|..|::.|.|   ..|.:..|...|:.|||:        |..|...:..:.||:.....:..|
Zfish   152 NKQRTAHQPKAA---SSERQIPIGQSTNQPQPM--------RDGAKVNSMLKSPPLIKTPPTVRQ 205

  Fly   179 SS--APVS-AVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGVAYHIERGDLA-KDWVIAGA 239
            .:  .||: .|..:...|||:..|.:||..::::|..||.:..|.:...:.|.:|. .|||....
Zfish   206 PTPRLPVNQEVAVEKFSGLRLRKPRLSSIDIEQKMASRKLIRLSQLPDRLARDNLEDSDWVTFAV 270

  Fly   240 LVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAG 304
            :::|...::...|..:|.|||:||......:|||||...|..||||..|..:.:|||...:.:.|
Zfish   271 IINKITPQSKNNGKTFSIWKLNDLHNLEVNVSLFLFGSVHTDLWKTDTGTVIGILNPNPMKNKEG 335

  Fly   305 SSDVACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDCDYCIFHVKQEYGKM-SRRS 368
            |:::: |::|..|||:|:|::.|.|||:|.|||||.||.:|||.:|.:|.:|||.:|.|| |:|:
Zfish   336 SNELS-LTVDHPQKVLIIGEAMDFGTCKAKKKNGDSCTQLVNLYECQFCQYHVKAQYKKMSSKRA 399

  Fly   369 ELQSATA------GRGINELRNKVLGKNEVFYGGQTFTAVPARKSAKLITKERDRLSMLAGYDVS 427
            ||||:..      |||...|:.: |.:::..|||.:..|.....||....|:....|.||.....
Zfish   400 ELQSSFTGSAPGKGRGRGSLKER-LCQSDFHYGGMSSLACAPSMSAPQPKKQPTIQSALASIPTK 463

  Fly   428 PFAHTANHTS------KPKTAEPTKIPYAERGGPVSRLAGGVEAS--RKQRVQDLERLRLLKEEN 484
            .....:...|      :...:.||  |.|..   :.|..|..::|  ....||.:....|||::.
Zfish   464 KLVLNSGQVSGCSDDFRGLMSMPT--PGALN---IKRHLGQSKSSAVAGSSVQSVSASDLLKQQK 523

  Fly   485 ERFEKKKQAEGHVLGSDNKKESE---------AGTPAVS----------MPTTPVPDKFKNRGFS 530
            |:.:::..|        .||.:|         .|.|..|          :......:..|..|.|
Zfish   524 EQHQQRMMA--------RKKRAEEIQKRVLQSGGAPVASSRPNVSRGPLLSPKAASEGPKGSGSS 580

  Fly   531 FDASLTPKL----SGSENFSFEINVGSRQAQNA-KLKAAALLKKK--PLEKINPNSTR------G 582
            ......|.|    |..|:..|:::..|.::.:| ||.|...|:.|  .:.|.:||:.:      |
Zfish   581 LSGPAVPTLGRGFSEGEDIVFDMSPPSSKSLSATKLAAVRKLQAKGSVIVKEDPNAVKRKRANSG 645

  Fly   583 SESG-------KRRAIDE--LNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMRE 638
            ..:|       |.:..||  .:|:...:.|:::   :..|.::....::|:.|.||::.::...|
Zfish   646 DITGRVERNIVKAKVTDENSASEEEEPAMKKRR---EQLEYIQSEEFQRILNAKSSNSWMMGEIE 707

  Fly   639 REAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSASDRCKEQKHPLKVVDAEKRFF 703
            ..|.:|||..|.:||.|||||.:..:|.|:||.|:.||||.|..:|||.|:||.....||.||||
Zfish   708 ERAMQEYFEPLVQKEKMEEKMKSIREMKCRAVTCKTCKYTHFKPADRCVEEKHDYHWHDAVKRFF 772

  Fly   704 QCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREKK-ILTGRETLSVRGDEE 756
            :| .||.|...:.::|..:|.:|...:|:|..|::||| ...|.|.|..||:|:
Zfish   773 KC-PCGQRKICLARMPHGACSHCGLFKWERDGMLKEKKGPKIGGELLMPRGEEQ 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm10	NP_610097.2	zf-primase	323..367	CDD:286419	25/44 (57%)
Mcm10	NP_610097.2	Mcm10	468..756	CDD:286422	96/329 (29%)
mcm10	NP_001019984.1	N-terminal domain. /evidence=ECO:0000250	1..122		23/99 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..208		46/196 (23%)
		OB-fold domain. /evidence=ECO:0000250	202..360		51/158 (32%)
		zf-primase	353..398	CDD:286419	25/44 (57%)
		Zinc finger-like 1	361..386		14/24 (58%)
		Mcm10	486..831	CDD:286422	104/357 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	502..589		18/94 (19%)
		Zinc finger-like 2. /evidence=ECO:0000250	741..760		10/18 (56%)
		Zinc finger-like 3. /evidence=ECO:0000250	774..794		6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583927
Domainoid	1	1.000	122	1.000	Domainoid score	I5622
eggNOG	1	0.900	-	-		E1_KOG3056
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41275
Inparanoid	1	1.050	284	1.000	Inparanoid score	I2851
OMA	1	1.010	-	-		QHG46518
OrthoDB	1	1.010	-	-		D450349at33208
OrthoFinder	1	1.000	-	-		FOG0004424
OrthoInspector	1	1.000	-	-		oto40217
orthoMCL	1	0.900	-	-		OOG6_104520
Panther	1	1.100	-	-	LDO	PTHR13454
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R691
SonicParanoid	1	1.000	-	-		X5568
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800