Protein Alignment Mcm10 and mcm10

DIOPT Version :10

• Sequence 1: NP_610097.2
• Gene: Mcm10 / 35390
• FlyBaseID: FBgn0032929
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_001016909.1
• Gene: mcm10 / 549663
• XenbaseID: XB-GENE-1015391
• Length: 845
• Species: Xenopus tropicalis
• Alignment Length: 909
• Identity: 254/909 - (27%)
• Similarity: 393/909 - (43%)
• Gaps: 239/909 - (26%)

  Fly    12 SIDDEEEILALEKLLGAAENENTKSAESEKAKP-----------------------TAPILVPKL 53
            ::|.:.|:|.  .||...|...:.|.||.:|..                       |....|..:
 Frog     3 AVDADLELLT--SLLEENEAAESNSVESHEASSELDEYDELFDGDEDGSYHESDNGTEEQTVDGV 65

  Fly    54 RE--DNSFANA--FTFEKIVKPEKQKNAAIIKEPELDSSDDEEVKNFLERKYNEYGSDINKRLKQ 114
            .|  |..|.:.  ...|:.|.|:.:|.:::.::......:||                    |::
 Frog    66 EENFDTLFGDIDDINEEETVAPDTKKQSSVCQDKSKHELEDE--------------------LRK 110

  Fly   115 QQENAYESKVAREVDQELKKSIHVVTSTP-QPLKNPHN--------------------------- 151
            .||.      .|::.::|:::....||:| .|:|:|.|
 Frog   111 MQEQ------MRKLQKQLQQTALAKTSSPGNPMKSPDNKLLLSGKTFQSGPLLERSLTVPKANLQ 169

  Fly   152 -------------PIKRQSAVSTTFQRPPPVAAAVASTSQSSAPVSAVFTDPVF----------- 192
                         |:::|   .|:|..||        ...|:.|||:..|.||.
 Frog   170 DTPKRKQNLQDKSPLQKQ---MTSFLSPP--------DKSSTRPVSSTATQPVLNPVRSPVGQQY 223

  Fly   193 ------GLRMINPLVSSSLLQERMTGRKPVPFSGVAYHIERGDLA-KDWVIAGALVSKNPVKNTK 250
                  |||:..|.||||.::.:|.|||.:..:.:...|....|. :|||..|.:|.|...:::.
 Frog   224 PVEKFSGLRLRKPRVSSSEMERKMNGRKLIRLAQLQNKIVTEKLEDEDWVTFGVIVKKITPQSSN 288

  Fly   251 KGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAGSSDVACLSIDS 315
            .|..:|.|:|:||:...|.:|||||.:.||..|||.:|..:.:||....:.:.|:.:| |||:|:
 Frog   289 NGKTFSIWRLNDLKNLDKYVSLFLFGDVHKEHWKTDQGTVIGLLNANPMKPKEGTDEV-CLSVDN 352

  Fly   316 SQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDCDYCIFHVKQEYGKM-SRRSELQSATAG--- 376
            .|||:::|.:.|||||:|.|||||.||.:|||.||:||.:||:.:|.|: |:|::|||:.:|
 Frog   353 PQKVLLMGDAVDLGTCKARKKNGDPCTQMVNLNDCEYCQYHVQAQYKKVSSKRADLQSSYSGHVP 417

  Fly   377 ----RGINELRNKVLGKNEVFYGGQTFTAVPARKSAKLITKERDRLSMLAGYDVSPFAHTANHTS 437
                ||.|.||.: |.::...|||                     :|.:|      :|.|...|:
 Frog   418 KKMARGGNGLRER-LCQDGFHYGG---------------------VSSMA------YATTLASTT 454

  Fly   438 KP-KTAEPTKIPYAERGGPVSRLAG--GVEASRKQRVQDLE-----------RLRLLK------- 481
            .| ||.:.|......||.....|..  .:.|:||..||..|           .|.|.|
 Frog   455 APKKTVQSTLSNMVVRGAEAIALEARQQIAAARKNMVQSDEFKELMTLPTPGALNLKKHFSGVPT 519

  Fly   482 EENER----FEK------KKQAEGHVLGSDNKK-------------ESEAGTPAVSMPTTPVPDK 523
            :.||:    |:.      .||.:..:||:..|:             :||..:..||...:.....
 Frog   520 QANEKGGQPFQSISASALLKQQKQQMLGARKKRAEEIQKRFLESTEKSEKSSTLVSSERSVFQSP 584

  Fly   524 FKNRGF-SFDASLTPKL-----SGSENFSFEIN----VGSRQAQNAKLKAAALLKKK--PLEKIN 576
            .:...| :.....||||     .|.:...|:|:    ..:..||..||.|...|:.|  .|.|.:
 Frog   585 KQGAEFPNAQKMATPKLGRGFAEGEDVLFFDISPPAAKSNTSAQATKLAAIQKLQAKGQTLTKAD 649

  Fly   577 PNSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDRE-LMRKSR----------IEKIMAATSSH 630
            |||.:...|..  |.:.:.::.:|.|.......|:.| .|:|.|          .:||:.|.|.|
 Frog   650 PNSIKRKRSSS--AEELVAQRVASHAPASTKSPDENEPAMKKHREQLAYLESKEFQKILNAKSKH 712

  Fly   631 TNLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSASDRCKEQKHPLKV 695
            |.:::..|.|.||.||:.|.:||.:||||.:..:..|:.|.|:.||||.|...:.|..:.|....
 Frog   713 TGILKEAEAEIQERYFDPLVKKEQLEEKMRSIREQECRVVTCKTCKYTHFKPKETCVSENHDFHW 777

  Fly   696 VDAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREKKILTG----RETLSVRGDE 755
            .:..||||:|. |||||.::.:|||:.|..|...:|:|..|::||   ||    .|||..||:|
 Frog   778 HNGVKRFFKCA-CGNRTISLDRLPKKHCSTCGLFKWERDGMLKEK---TGPKIAGETLLPRGEE 837

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm10	NP_610097.2	zf-primase	323..365	CDD:462758	25/42 (60%)
		Mcm10	462..755	CDD:462760	106/360 (29%)
mcm10	NP_001016909.1	N-terminal domain. /evidence=ECO:0000250	1..145		33/169 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..65		8/49 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..218		31/176 (18%)
		OB-fold domain. /evidence=ECO:0000250	217..367		52/150 (35%)
		zf-primase	360..405	CDD:462758	26/44 (59%)
		Zinc finger-like 1	368..393		16/24 (67%)
		Mcm10	501..844	CDD:462760	101/343 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	564..586		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	643..688		11/46 (24%)
		Zinc finger-like 2. /evidence=ECO:0000250	754..773		7/18 (39%)
		Zinc finger-like 3. /evidence=ECO:0000250	787..807		10/20 (50%)