DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm10 and Mcm10

DIOPT Version :9

Sequence 1:	NP_610097.2	Gene:	Mcm10 / 35390	FlyBaseID:	FBgn0032929	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_001100836.1	Gene:	Mcm10 / 307126	RGDID:	1311330	Length:	889	Species:	Rattus norvegicus

Alignment Length:	915	Identity:	256/915 - (27%)
Similarity:	405/915 - (44%)	Gaps:	197/915 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DEEEILALEKLL----------GAAENENTKSAESEKAKPTAPILVPKLREDNSFANAFTFEK-- 67
            :|:::..|..||          |:.|||  ||:..|:..|..   ..:|.:.:....::|.|.
  Rat     4 EEDDLCVLTSLLEENEAAAVPCGSEENE--KSSSLEEGDPDE---FDELFDADGDGESYTEEADS 63

  Fly    68 ----IVKPEKQKNAAIIKEPELDSSDDEEVKNFLE------------RKYNEYGSDINKRLKQQQ 116
                ..:.::::.|.:..:.| |.:|||...:.:|            .|.|:...|..|:|::|.
  Rat    64 GEEGKTRDQEERLATLFGDVE-DLTDDEVPTSQVEDSSVPPAPVRSREKTNQELQDELKKLQEQM 127

  Fly   117 ENAYESKVA--------------------REVDQELK----------------------KSIHVV 139
            ::..|...|                    |...||.|                      |.:..|
  Rat   128 KSLQEQLKAASLQQPPSSAPLHEPPGASLRPPPQEKKVRRIQESVCFSAELDVPALPRAKRVARV 192

  Fly   140 TSTP-----------QPLKNPHNPIKRQSAVSTTFQRPPPVA---------------AAVASTSQ 178
            ..||           |||:...:.::.:|:.:.:...|.|.|               |...:..:
  Rat   193 PKTPAESSSRTSAPSQPLRVISSFLEPKSSPARSTSIPSPQAVPGNKCSGMTKNQSKATPGNPGE 257

  Fly   179 SSAPVSAVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGVAYHIERGDLAK-DWVIAGALVS 242
            .|..|..|..:...|||:..|.|||:.:..:|||||.:..|.:...:...:|.: |||..|.::.
  Rat   258 PSPQVPQVSVEAFSGLRLRRPRVSSTEMNRKMTGRKLIRLSQIKEKMATENLEETDWVTFGVILR 322

  Fly   243 KNPVKNTKKGDPYSTWKLSDLRGEVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAGSSD 307
            |...::...|..:|.|||:|||...:.:|||||.:.||.||||.:|..:.:||....:.:.|.::
  Rat   323 KVTPQSANSGKTFSIWKLNDLRDLTQCVSLFLFGDVHKDLWKTEQGTVIGLLNANPMKPKEGLTE 387

  Fly   308 VACLSIDSSQKVMILGQSKDLGTCRATKKNGDKCTSVVNLTDCDYCIFHVKQEYGKMS-RRSELQ 371
            | |||||..|||:|:|::.|||||:|.||||:.||..|||.||:||.:|::.:|.|:| :||:||
  Rat   388 V-CLSIDHPQKVLIMGEAMDLGTCKAKKKNGEPCTQTVNLHDCEYCQYHIQAQYKKLSAKRSDLQ 451

  Fly   372 SATAG--------RGINELRNKVLGKNEVFYGGQTFTAVPARKSAKLITKERDRLSM----LAGY 424
            |..:|        || ..|:.: |.::..:|||.:..:..|..:|.:..|::.:.::    :.|
  Rat   452 STFSGGRIPKKFRRG-TSLKER-LCQDGFYYGGVSSESFAASMAAAIAPKKKVQTTLTNLVVRG- 513

  Fly   425 DVSPFAHTANHTSKPKTAEPTK-------------IP-YAERGGPVSRLAGGVEASRKQRVQDLE 475
                 ..:....:|.|...|.|             :| :..|.............|.|..:|.:.
  Rat   514 -----TRSVIQETKQKLGIPQKSLSCSEEFRELMALPTFGARNLQKHLARAKSSGSPKPAIQSIS 573

  Fly   476 RLRLLKEENE-----RFEKKKQAEGHVLGSDNKKESEA-----GTPAVSMPTTPVPDKFKNRGFS 530
            ...|||::..     |..|.::.:...|.|.::.:|.|     ..||...|.|         |..
  Rat   574 ASALLKQQKHQMLEMRKRKSEEIQKRFLQSSSEVQSAAVPSSSRQPAAQSPRT---------GAE 629

  Fly   531 F------DASLTPKL-----SGSENFSFEINVG-----SRQAQNAKLKAAALLKKKP--LEKINP 577
            |      :|..||||     .|.:...|:.:..     |..|:..||.|.:.|:.|.  |.|::|
  Rat   630 FPRLEGTEAPWTPKLGRGISDGDDVLFFDESPPPKPKLSAAAEAKKLAAISKLRAKGQILTKVDP 694

  Fly   578 NSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDRELMRKSR-----------IEKIMAATSSHT 631
            |:....:...|   |.|..|..:........||:.|..||.|           .:||:.|.|.||
  Rat   695 NNIVRRQMDPR---DVLGVKERAENSNTVSPEDELEPARKKRREQLAYLESEEFQKILKAKSKHT 756

  Fly   632 NLVEMREREAQEEYFNKLERKEAMEEKMLTTYKMPCKAVICQVCKYTAFSASDRCKEQKHPLKVV 696
            ::::..|.|.|:.||:.|.:||.|||||....::.|:.|.|:.|.||.|...:.|..::|.|...
  Rat   757 DVLKEAEAELQKSYFDPLVKKEQMEEKMRAVREVKCRVVTCRKCAYTHFKPLETCVSEQHNLHWH 821

  Fly   697 DAEKRFFQCKDCGNRTTTVFKLPKQSCKNCKGSRWQRTAMIREK---KILTGRETLSVRGDEET- 757
            |..||||:| .|||||.::.|||.:.|:||...:|:|..|::||   ||  |.|||..||:|..
  Rat   822 DGVKRFFKC-PCGNRTISLDKLPNKHCRNCGLYKWERDGMLKEKTGPKI--GGETLLPRGEEHAK 883

  Fly   758 FMGCL 762
            |:..|
  Rat   884 FLNSL 888

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm10	NP_610097.2	zf-primase	323..367	CDD:286419	24/44 (55%)
Mcm10	NP_610097.2	Mcm10	468..756	CDD:286422	104/329 (32%)
Mcm10	NP_001100836.1	zf-primase	402..447	CDD:286419	8/62 (13%)
Mcm10	NP_001100836.1	Mcm10	545..887	CDD:286422	82/224 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343679
Domainoid	1	1.000	127	1.000	Domainoid score	I5279
eggNOG	1	0.900	-	-		E1_KOG3056
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41275
Inparanoid	1	1.050	281	1.000	Inparanoid score	I2819
OMA	1	1.010	-	-		QHG46518
OrthoDB	1	1.010	-	-		D450349at33208
OrthoFinder	1	1.000	-	-		FOG0004424
OrthoInspector	1	1.000	-	-		oto98539
orthoMCL	1	0.900	-	-		OOG6_104520
Panther	1	1.100	-	-	LDO	PTHR13454
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5568
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860