Protein Alignment Mcm10 and cdc23

DIOPT Version :9

• Sequence 1: NP_610097.2
• Gene: Mcm10 / 35390
• FlyBaseID: FBgn0032929
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_596702.1
• Gene: cdc23 / 2539838
• PomBaseID: SPBC1347.10
• Length: 593
• Species: Schizosaccharomyces pombe
• Alignment Length: 653
• Identity: 143/653 - (21%)
• Similarity: 238/653 - (36%)
• Gaps: 182/653 - (27%)

  Fly    79 IIKEPELDSSDDEEVKNFLERKYNEYGSDINKRLKQQQ-----ENAYESKVAREVDQELKKSIHV 138
            |.:|.:||..:..     |:|:.||...  .|||:..|     |||...:|.|...|:    :.|
pombe     6 IAEENDLDLEEKR-----LQRQLNEIQE--KKRLRSAQKEASSENAEVIQVPRSPPQQ----VRV 59

  Fly   139 VT-STPQPLKNPHNPI--------------------------------------KRQSAVST--- 161
            :| |:|..||:|...|                                      ||...:.|
pombe    60 LTVSSPSKLKSPKRLILGIDKGKTGKDVSLGKGPRGPLPKPFHERLAEARNQERKRSDKLKTMKK 124

  Fly   162 ----TFQRPPPVAAAVASTSQSSAPVSAVFTDPVFGLRMINPLVSSSLLQERMTGRKPVPFSGVA 222
                :|||...:... ..:.:...|:.....||.....::...:|..:.:|.:.|.:       .
pombe   125 NRKQSFQRKRNILED-GKSEEEKFPMKCDEIDPYSRQAIVIRYISDEVAKENIGGNQ-------V 181

  Fly   223 YHIERGDLAK-------------DWVIAGALVSKNPVKNTKKGDPYSTWKLSDLRGEVKTISLFL 274
            |.|.:  |.|             ::|:.|.:.|.:..:.|..|:.|....|:||:.:   :..||
pombe   182 YLIHQ--LLKLVRAPKFEAPEVDNYVVMGIVASNSGTRETVNGNKYCMLTLTDLKWQ---LECFL 241

  Fly   275 FKEAHKSLWKTAEGLCLAVLNPTIFERRAGSSDVACLSIDSSQKVMI-LGQSKDLGTCRATKKNG 338
            |.:|.:..||...|..:|:|||.:.:.:........|.:||...|:: :|:||.||.|.:.:|:|
pombe   242 FGKAFERYWKIQSGTVIALLNPEVLKPKNPDIGRFSLKLDSEYDVLLEIGRSKHLGYCSSRRKSG 306

  Fly   339 DKCTSVVNLTDCDYCIFHVKQEYGK-MSRRSELQSATAGRGINELRNKVLGKNEVFYG---GQTF 399
            :.|...::....|.|.:||.....: ||.|:|..|:.|.......|.:...:.:.|.|   |:.:
pombe   307 ELCKHWLDKRAGDVCEYHVDLAVQRSMSTRTEFASSMATMHEPRARREKRFRGQGFQGYFAGEKY 371

  Fly   400 TAVPARKSAKLITKERDRLSMLAG-YDVSPFAHTANHTSKPKTAEPTKIPYAERGGPVSRLAGGV 463
            :|:|               :.:|| ||    |..|..|.:.:.
pombe   372 SAIP---------------NAVAGLYD----AEDAVQTERERK---------------------- 395

  Fly   464 EASRKQRVQ-DLER---LRLLK-----------EENERFEKKKQAEGH----VLGSDNKKESEAG 509
            |..:|||.| :.||   :||.|           ..|.......:..||    :.||..|...:.|
pombe   396 ERYKKQRAQAEREREILVRLSKRCCASSSSSSNSNNLSTGMSMRTLGHQYLNLQGSGVKNLHDKG 460

  Fly   510 TPAVSMPTTPVPDKFKNRGF--SFDASLTPKLSGSENFSFEINVGSRQA----------QNAKLK 562
            .|......:.:....|....  ||:||:....|...:||....:|:..|          .:.|:.
pombe   461 NPTALSKDSEIDSSTKKPSVLASFNASIMNPKSSLPSFSNSAILGTNDAASGTPVPQDTTSTKVS 525

  Fly   563 AAALLKKKP-------LEKI--------NPNSTRGSESGKRRAIDELNEKFSSSAKRQKIDEDDR 612
            .|.:....|       |.||        :.::|..:.:|..|:....|.||.... .:..||||.
pombe   526 PAVVFTSSPRIFSPQSLRKIGFDPTHSADASTTHSTATGLSRSGSLKNIKFRYEF-TESDDEDDL 589

  Fly   613 ELM 615
            |::
pombe   590 EIV 592

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcm10	NP_610097.2	zf-primase	323..367	CDD:286419	15/44 (34%)
		Mcm10	468..756	CDD:286422	44/194 (23%)
cdc23	NP_596702.1	zf-primase	291..336	CDD:286419	15/44 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3056
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004424
OrthoInspector	1	1.000	-	-		oto101998
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13454
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R691
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030