DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcm10 and mcm-10

DIOPT Version :9

Sequence 1:	NP_610097.2	Gene:	Mcm10 / 35390	FlyBaseID:	FBgn0032929	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_499456.1	Gene:	mcm-10 / 176562	WormBaseID:	WBGene00012935	Length:	691	Species:	Caenorhabditis elegans

Alignment Length:	829	Identity:	197/829 - (23%)
Similarity:	328/829 - (39%)	Gaps:	208/829 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGPAQKSGTDISIDDEEEILALE---KLLGAAEN-ENTKSAESEKAKPTAPILVPKLREDNSFAN 61
            |.|.....|.:...:|||:..:.   :||...|. ||..|:|    ||:          |:|..|
Worm     1 MDPLDDLLTQLEGVEEEELKPVNRAPRLLNMEEACENQGSSE----KPS----------DSSSKN 51

  Fly    62 AFTFEKIVKPEKQKNAAIIKEPELDSSDDEE--VKNFLERKYNEYGSDINKRLKQQQENAYESKV 124
            .:                    |.|.|||||  ||   :|:..|.|:.:.:.|  ::.::.....
Worm    52 RY--------------------EDDDSDDEELYVK---KRELTEQGALLKRHL--EKNSSTSGPK 91

  Fly   125 AREVDQELKKSIHVVTSTPQPLKNPHNPIKRQSAVSTTFQRPPPVAAAVASTSQSSAPVSAVFTD 189
            |.:..:..|||  |:|...:|                               |..:..|..|..|
Worm    92 ATDAWKTNKKS--VLTGLTKP-------------------------------STDTVTVGIVRFD 123

  Fly   190 PVFGLRMINPLVSSS--------LLQERMTGRKPVPFSGVAYHIERGDLAKDWVIAGALVSKNPV 246
            . |.:.:.||.:|::        :..|:::..||.           .:..:.|...|.:|.|...
Worm   124 K-FQISIRNPKISATSFGAFTAGMKLEKLSNLKPT-----------SNFKEAWCTIGVIVEKGFK 176

  Fly   247 KNTKKGDPYSTWKLSDLRG-EVKTISLFLFKEAHKSLWKTAEGLCLAVLNPTIFERRAGS----S 306
            |.:..|:.:..|||.||:. :.:.:.|.:|.:|.|..|:...|..:|:::..|.:....|    :
Worm   177 KKSANGNDFLIWKLHDLKDCQTQPVKLLMFGDAIKDHWEIKLGSVIALISAQIADDSTASGAKKT 241

  Fly   307 DVACLSIDSSQKVMILGQSKDLGTCRATK-KNGDKCTSVVNLTDCDYCIFHVKQEYGKMS-RRSE 369
            ..|.|.:..|..::.:|||...|||:..: ::|.:|::.||.:..::|:|||.....|:| :|..
Worm   242 VSATLKVAKSNNIVEIGQSAHFGTCKGIRQQDGQRCSNFVNSSLSEFCVFHVMSAARKLSAKRGV 306

  Fly   370 LQSATAGRGINELRNKVLGKNEVFYGGQTFTAVPARKSAKLITKERDRLSMLAGYDVSPFAHTAN 434
            ..:.|.|..:               ||.:|...|......:.::.....|.||....||.   ..
Worm   307 FNAVTCGPNV---------------GGLSFNKKPGTPRPPISSRPGISGSGLATSSGSPM---LR 353

  Fly   435 HTSKPKTA----EPT----KIPYAERGGPVSRLAGGVEASRKQRVQDLERLRLLKEENERF---- 487
            .|.:|..:    .||    ||...|....::.|.    :.||......:.|:|.::::|:.
Worm   354 DTMRPADSFTLTTPTSGLKKITKEEEKSSLNDLL----SQRKNTFAARQMLKLKEKKDEKLAESV 414

  Fly   488 ------------EKKKQAE---GHVLGSDNKKESEA-----------GTPAVSMPTTPVPDKFKN 526
                        |:|....   |..|.:|.::|..|           ||.|    ::|...|.
Worm   415 EEMIEFLGTTGGEEKPSVHSSFGEFLAADTRREKAATVDLRASSATSGTSA----SSPGGSKL-- 473

  Fly   527 RGFSFDASLTPKLSGSENFSFEINVGSRQAQN--AKLKAAALLKKKPLEKINPNSTRGSESGKRR 589
                :..||..|.:..        :|.:.||.  |:|:|.|:||.|..|......|.|....||:
Worm   474 ----WTMSLANKKAAP--------LGHKDAQEHAARLRAIAILKAKRKEAEMEKLTGGGGGVKRK 526

  Fly   590 A--IDELNEKFSSSAKRQKIDEDDRELMRKSRIEKIMAATSSHTNLVEMREREAQEEYFNKLERK 652
            |  .....|..:...:.||:||          |..::|..|:|....|..|.:..:.:...:|.:
Worm   527 ASGTPTAPEPEAKKPRSQKMDE----------IRAMLARKSTHHKEAEKAEHDMLQRHLTGMEER 581

  Fly   653 EAMEEKMLTTYKMPC------KAVICQVCKYTAFSASDRCKEQKHPLKVVDAEKRFFQCKDCGNR 711
            |.:|     |:...|      |.|.|..||||:..||..|.:::|.|....|:||||:|..|..|
Worm   582 EKVE-----TFTTTCVEVKNVKVVTCNQCKYTSQFASSECIKKEHKLIKHTADKRFFKCTGCKKR 641

  Fly   712 TTTVFKLPKQSCKNCKGSRWQRTAMIREKKILTGRETLSVRGDEETFMG 760
            |.....:|.:.|.:|..::|:|.||..|:|::...|.|.:||:|..|:|
Worm   642 TVCFEMMPVKHCAHCNENKWERVAMKDERKVVLDTENLLLRGEERPFVG 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcm10	NP_610097.2	zf-primase	323..367	CDD:286419	16/45 (36%)
Mcm10	NP_610097.2	Mcm10	468..756	CDD:286422	85/327 (26%)
mcm-10	NP_499456.1	zf-primase	258..304	CDD:370437	16/45 (36%)
mcm-10	NP_499456.1	Mcm10	365..691	CDD:370440	95/363 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161235
Domainoid	1	1.000	107	1.000	Domainoid score	I4078
eggNOG	1	0.900	-	-		E1_KOG3056
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	165	1.000	Inparanoid score	I2811
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46518
OrthoDB	1	1.010	-	-		D450349at33208
OrthoFinder	1	1.000	-	-		FOG0004424
OrthoInspector	1	1.000	-	-		oto17885
orthoMCL	1	0.900	-	-		OOG6_104520
Panther	1	1.100	-	-	LDO	PTHR13454
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R691
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.890