DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9246 and Noc2l

DIOPT Version :9

Sequence 1:	NP_610095.1	Gene:	CG9246 / 35386	FlyBaseID:	FBgn0032925	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	XP_006239646.1	Gene:	Noc2l / 313777	RGDID:	1309387	Length:	748	Species:	Rattus norvegicus

Alignment Length:	762	Identity:	264/762 - (34%)
Similarity:	433/762 - (56%)	Gaps:	86/762 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 ETKVTPRNPKQKVAEPVKNGKTTK----KGFKKSHKEELEGLKDIDPEFYDFLKNNDKKLLDFNL 98
            |.....:..::.||...:.|..|.    ||....||::|..|||.|||||.||:.||:.||:|:.
  Rat    37 EPAAKEKKGQRAVANREQRGAHTSPSLHKGRASEHKDQLSRLKDRDPEFYKFLQENDQSLLNFSD 101

  Fly    99 LDTDDDDDEEGDEEDKEDTVTKESKDDEDDEEKYHKPSKDLEVASDESDFEVDEEDDAAAGGIQK 163
            .||                       ..::||::|.....||..| |::.:...:.|....|:|:
  Rat   102 SDT-----------------------SVEEEEQFHSLPDRLEETS-ETEEDGGGDSDTLPRGLQR 142

  Fly   164 -------ITLNLLHQWEQQLGQANISIDIVRKVIQAFNSALASISADGADGGENKHNAAAFKVVG 221
                   :||.::.:|:|. ...:::..:..:|:|||.:|:|:     ..|.:.......|:|..
  Rat   143 KKNEPVPVTLAMVERWKQG-AMHHLTPKLFHEVVQAFRAAVAT-----TQGDQEAPETCRFQVTD 201

  Fly   222 AAAFNGVIQLCVIHLQPAIIRLLGVR----------PNSSLPLHKHKKWVKVRGCLRYYLTDLIR 276
            :|.||.::..|:..|...:.:||..:          |:|| ||     |.|:|..::.||:.:::
  Rat   202 SAVFNALVTFCIRDLCGCLQKLLFAKTVKDSSRMLLPSSS-PL-----WGKLRVDVKTYLSAVVQ 260

  Fly   277 LVEQVSSPNILGVLLKHLHQMAGMVVPFSALGKTILKRLVVLWSTGDETVRVLAFLCILKITRKQ 341
            ||..::...:...:|:|:..:....:.|....:.::||::||||||:|::||||||.::|:.|.:
  Rat   261 LVASLAEATVSAAVLQHISSLVPYYLTFPKQCRMLVKRMIVLWSTGEESLRVLAFLVLIKVCRHK 325

  Fly   342 QATMLNHVLKAMYLAYVRNSKFVSPNTLPGINFMRRSLVEMFALDLNVSYQHVFLYIRQLAIHLR 406
            :.:.|..:||.||:.||||.||.||:|||.|:||:|:|.|:.|||.:|||||.||||||||:|||
  Rat   326 KESFLGPILKQMYIMYVRNCKFTSPSTLPLISFMQRTLTELLALDPSVSYQHAFLYIRQLAVHLR 390

  Fly   407 NAVILKKKDSFQAVYNWQFINSLRLWADLLGASANKPQLQPLIYPLVTIATGVIRLIPTAQYFPL 471
            ||:...||:::|:|||||:::.|.||..:|.|..:...||||:|||..|..|.|:|:|||:::||
  Rat   391 NAMTTGKKETYQSVYNWQYVHCLYLWCRVLSALGSSEVLQPLLYPLSQIIIGCIKLLPTARFYPL 455

  Fly   472 RFHCLQTLISLAKETNTYVPVLPLIVEVLKSNTFNRKHSAVSMKPVQFTCVLRLNKGQLAENGFR 536
            |.||::.|..|::...|::||||.|:|:.:...||::...:|.||:.|:.:|:|:...|.|..:|
  Rat   456 RMHCVRALTLLSQTVGTFIPVLPFILEIFQQVDFNKRPGRMSSKPINFSVILKLSSTNLQEKAYR 520

  Fly   537 DEVIEQVCGLLLEYLAHESTSLAFSDLVVPTVMAIKTYLKECRNANYARKLKQLLEKIQESARFI 601
            |.::||:..|::|||..::.|:||.:||:|||:.:|::|:||:.|||.|:::|||||:||:|..|
  Rat   521 DGLLEQLYDLIMEYLHGQAHSIAFPELVLPTVLQLKSFLRECKVANYCRQVRQLLEKVQENAEHI 585

  Fly   602 EQQRGKSSVTFDIKDAQAVAAWEQQLRLKRTPLDVYYASWLKTHETKKRRQAAHTDEINADYDVP 666
            ...|.:  |||.:.|..||.|||:::|.:.|||..||:.|.|..:.:.:.:.:..:.:. |.:.|
  Rat   586 RSLRQR--VTFSVSDQLAVDAWEKKVREEGTPLTRYYSHWKKLRDREIQLEISGKERLE-DLNFP 647

  Fly   667 KLKKLPVKTGVPVRNENGEVE---LFPSDSEDEGDDGLHLGSDDDDDEDVQEEEEVEVEHPKAKK 728
            ::|:..|:.    |.:....|   ||..|| .||:|     |.|..:..|....|   .|...|:
  Rat   648 EIKRRKVED----RKDEDRKELKDLFELDS-SEGED-----STDFFERGVPGLLE---SHRGMKE 699

  Fly   729 AKKEKPEKQKPRPATVEDDYDE----------AGGAVDIVKDLDLNE 765
            ..:|:..|:....::.:.|.|.          |.|..|.::||.|:|
  Rat   700 GGQEEEHKEDSDSSSEDGDTDTGVDLSELWQLAQGPQDELEDLQLSE 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9246	NP_610095.1	Noc2	344..641	CDD:281678	143/296 (48%)
Noc2l	XP_006239646.1	Noc2	328..623	CDD:281678	143/296 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338174
Domainoid	1	1.000	308	1.000	Domainoid score	I1293
eggNOG	1	0.900	-	-		E1_COG5604
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6980
Inparanoid	1	1.050	404	1.000	Inparanoid score	I1855
OMA	1	1.010	-	-		QHG54054
OrthoDB	1	1.010	-	-		D1194328at2759
OrthoFinder	1	1.000	-	-		FOG0003746
OrthoInspector	1	1.000	-	-		oto95674
orthoMCL	1	0.900	-	-		OOG6_102068
Panther	1	1.100	-	-	LDO	PTHR12687
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2606
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810