DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9246 and NOC2L

DIOPT Version :9

Sequence 1:	NP_610095.1	Gene:	CG9246 / 35386	FlyBaseID:	FBgn0032925	Length:	766	Species:	Drosophila melanogaster
Sequence 2:	NP_056473.3	Gene:	NOC2L / 26155	HGNCID:	24517	Length:	749	Species:	Homo sapiens

Alignment Length:	781	Identity:	268/781 - (34%)
Similarity:	434/781 - (55%)	Gaps:	111/781 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 KTKPQT-TSETKVTPRNPKQKVAEPVKNGKTTKKGFKKSHKEELEGLKDIDPEFYDFLKNNDKKL 93
            :..||. |.|.:...|:|.:....|   ..:.:||....||::|..|||.|||||.||:.||:.|
Human    33 ENSPQAETREAREAARSPDKPGGSP---SASRRKGRASEHKDQLSRLKDRDPEFYKFLQENDQSL 94

  Fly    94 LDFNLLDTDDDDDEEGDEEDKEDTVTKESKDDEDDEEKYHKPSKDLEVASDESD-FEVDEEDDAA 157
            |:|:  |:|..::|||                     .:|.....||.||:|.| .|..|:.|..
Human    95 LNFS--DSDSSEEEEG---------------------PFHSLPDVLEEASEEEDGAEEGEDGDRV 136

  Fly   158 AGGIQ------KITLNLLHQWEQQLGQANISIDIVRKVIQAFNSALASISADGADGGENKHNAAA 216
            ..|::      .:|:.::.:|:|...| .::..:..:|:|||.:|:|:...|......||
Human   137 PRGLKGKKNSVPVTVAMVERWKQAAKQ-RLTPKLFHEVVQAFRAAVATTRGDQESAEANK----- 195

  Fly   217 FKVVGAAAFNGVIQLCVIHLQPAIIRLL----------GVRPNSSLPLHKHKKWVKVRGCLRYYL 271
            |:|..:||||.::..|:..|...:.:||          .::|:|| ||     |.|:|..::.||
Human   196 FQVTDSAAFNALVTFCIRDLIGCLQKLLFGKVAKDSSRMLQPSSS-PL-----WGKLRVDIKAYL 254

  Fly   272 TDLIRLVEQVSSPNILGVLLKHLHQMAGMVVPFSALGKTILKRLVVLWSTGDETVRVLAFLCILK 336
            ...|:||..:|...:|..:|:|:..:....:.|....:.:|||:|::||||:|::||||||.:.:
Human   255 GSAIQLVSCLSETTVLAAVLRHISVLVPCFLTFPKQCRMLLKRMVIVWSTGEESLRVLAFLVLSR 319

  Fly   337 ITRKQQATMLNHVLKAMYLAYVRNSKFVSPNTLPGINFMRRSLVEMFALDLNVSYQHVFLYIRQL 401
            :.|.::.|.|..|||.||:.||||.||.||..||.|:||:.:|.|:.||:..|:|||.|||||||
Human   320 VCRHKKDTFLGPVLKQMYITYVRNCKFTSPGALPFISFMQWTLTELLALEPGVAYQHAFLYIRQL 384

  Fly   402 AIHLRNAVILKKKDSFQAVYNWQFINSLRLWADLLGASANKPQLQPLIYPLVTIATGVIRLIPTA 466
            |||||||:..:||:::|:|||||:::.|.||..:|..:.....||||:|||..:..|.|:|||||
Human   385 AIHLRNAMTTRKKETYQSVYNWQYVHCLFLWCRVLSTAGPSEALQPLVYPLAQVIIGCIKLIPTA 449

  Fly   467 QYFPLRFHCLQTLISLAKETNTYVPVLPLIVEVLKSNTFNRKHSAVSMKPVQFTCVLRLNKGQLA 531
            :::|||.||::.|..|:..:..::||||.|:|:.:...||||...:|.||:.|:.:|:|:...|.
Human   450 RFYPLRMHCIRALTLLSGSSGAFIPVLPFILEMFQQVDFNRKPGRMSSKPINFSVILKLSNVNLQ 514

  Fly   532 ENGFRDEVIEQVCGLLLEYLAHESTSLAFSDLVVPTVMAIKTYLKECRNANYARKLKQLLEKIQE 596
            |..:||.::||:..|.||||..::..:.|.:||:|.|:.:|::|:||:.|||.|:::|||.|:||
Human   515 EKAYRDGLVEQLYDLTLEYLHSQAHCIGFPELVLPVVLQLKSFLRECKVANYCRQVQQLLGKVQE 579

  Fly   597 SARFIEQQRGKSSVTFDIKDAQAVAAWEQQLRLKRTPLDVYYASWLKTHETKKRRQAAHTDEINA 661
            ::.:|..:|.:  |:|.:.:.|||.|||:..|.:.|||.:||:.|.|..:.:.:.:.:..:.:.
Human   580 NSAYICSRRQR--VSFGVSEQQAVEAWEKLTREEGTPLTLYYSHWRKLRDREIQLEISGKERLE- 641

  Fly   662 DYDVPKLKKLPVKTGVPVRNENGE--VELFPSDSEDEGD-DGL------------HLGSDDDDDE 711
            |.:.|::|:   :.....::|:.:  .:||..:|.:|.| :|.            |...||::||
Human   642 DLNFPEIKR---RKMADRKDEDRKQFKDLFDLNSSEEDDTEGFSERGILRPLSTRHGVEDDEEDE 703

  Fly   712 DVQEEEEVEVEHPKAKKAKKEKPEKQKPRPATVEDDYD-EAG-----------GAVDIVKDLDLN 764
            :..||:....|                      :.|.| |||           |..|.::||.|:
Human   704 EEGEEDSSNSE----------------------DGDPDAEAGLAPGELQQLAQGPEDELEDLQLS 746

  Fly   765 E 765
            |
Human   747 E 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9246	NP_610095.1	Noc2	344..641	CDD:281678	137/296 (46%)
NOC2L	NP_056473.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..82		16/51 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	96..143		17/69 (25%)
		Noc2	327..622	CDD:309001	137/296 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..749		24/102 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144466
Domainoid	1	1.000	293	1.000	Domainoid score	I1511
eggNOG	1	0.900	-	-		E1_COG5604
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6980
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1678
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54054
OrthoDB	1	1.010	-	-		D1194328at2759
OrthoFinder	1	1.000	-	-		FOG0003746
OrthoInspector	1	1.000	-	-		oto88537
orthoMCL	1	0.900	-	-		OOG6_102068
Panther	1	1.100	-	-	LDO	PTHR12687
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2208
SonicParanoid	1	1.000	-	-		X2606
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800