Protein Alignment Nbr and Y57A10A.13

DIOPT Version :10

• Sequence 1: NP_610094.1
• Gene: Nbr / 35385
• FlyBaseID: FBgn0032924
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: NP_496590.1
• Gene: Y57A10A.13 / 174858
• WormBaseID: WBGene00013256
• Length: 710
• Species: Caenorhabditis elegans
• Alignment Length: 763
• Identity: 159/763 - (20%)
• Similarity: 242/763 - (31%)
• Gaps: 329/763 - (43%)

  Fly    88 GHQDPLLLALKIFANCPDSSNIKTKSLSHFVLDTVCKLH-------------KDFPHLGEGCDPN 139
            |..|....|.|:|...|      |..|....::.:.:.|             ..:||
 Worm    41 GRFDFRQFAKKMFDPIP------TAQLGQLYIEMLEESHIYMHSHQKSRVGANGYPH-------- 91

  Fly   140 TSMIAFNFVKTSGLLALNNAVIHAYSLRQIRDLLLPKLRELLDNGLYKE---------------- 188
                  :||....|| ||  :|.||.|.|.|.:...|:.|  |.|..:|
 Worm    92 ------SFVSVPELL-LN--MILAYQLPQQRFVPAEKMEE--DGGKVEEDGGAGGAGGSRKKRRN 145

  Fly   189 ---------------VTQWSISLQLTHEFDMLELAFPLIAIEKLPLAEEYLDHATQQRLPFVKFL 238
                           |....::.:|..|  ||          |:|||.|.....|
 Worm   146 SAARKGKNVTINPRVVLGNELAAKLLEE--ML----------KIPLAPESKQWKT---------- 188

  Fly   239 DSLLHKEKSVL--ELCEHLLDRY-----KNLK---ISHNVLSYRPMAKIVARLAKKYGFDDAVTP 293
                  .|.||  ..|...::.:     ||.|   ||.|.|:|.....|:.|.     .||.:|
 Worm   189 ------AKYVLCPSSCPQQMEVFGEIIAKNTKSGLISFNALNYFMHDPILNRY-----LDDPIT- 241

  Fly   294 NYKFTKTCSYLHYLYREYEKTRMNLASFR-EVVSVHAFNHELRTDF-------VKYLASAGAHSE 350
                     .||.||         :...: ..|.:.|.|   |||.       |..:|...:...
 Worm   242 ---------ILHALY---------IGPLQAPTVELFATN---RTDVFRQRCREVLRIALHASKDP 285

  Fly   351 AIYWYT--EFNID---PKDCP----LEIETQVSQ--NGAGKAS-----GWESPGKERCPSSR--- 396
            ..:.|:  || ||   |..|.    :|..||:.:  ||..:.|     ||.....::....|
 Worm   286 MTFTYSVPEF-IDKNHPDRCSYRDFVETVTQLIRDLNGEHQGSTAIHTGWACAAIKKFGQKRYVD 349

  Fly   397 --------CDMYLTM--------------------DLP-------------------DECLIIVN 414
                    .|:..|:                    ||.                   ::.:|||:
 Worm   350 KTWKDENYYDLIWTVLAQRPHLKKFVVDVLEKNFKDLDAARFWRRMQPYQMNPTVIFNQNVIIVD 414

  Fly   415 KADEFDRML--------------------------YHLQQECVIY--LDSEWMQSVCGDNQLCVL 451
            .....|..|                          |.:.:|..||  :|:||...| ..::..:|
 Worm   415 PLQPTDEFLNFPPTVRHIQMVTNEKEIRDLQMLLEYKVSREEKIYVGVDAEWSAYV-SPSKATIL 478

  Fly   452 QIATGHNVYLIDCLARE-SLRSEHWRLLGANIFNNVNIRKVGFSMVSDLSVLQRSLPLQLRLQMP 515
            |::....:|:||..:.: |.:|.|..|  :.:|....|.|:||....||..|:.:....:.|..|
 Worm   479 QMSLHDCIYIIDLESYQISPQSYHHVL--SYLFETPEIVKIGFQFGEDLHQLRAAFRNCVALYRP 541

  Fly   516 HHYL--------------------DLRNLWL---------------------------------- 526
            ::.:                    |.|..||
 Worm   542 NNVVCVGKLIMDLMDEIGKLENCDDFRKEWLPHLTDNETSSAANSSVEEQANETIDTNESMDEGD 606

  Fly   527 -----------ELKKQRFGVELPFGNVNRAGDALTDLSLAC---LGKKLNKSNQCSNWANRPLRR 577
                       |..||:|        :|:.      ||..|   ||:.|:|:.|||.|..||||.
 Worm   607 GGGSGIVVKKEESVKQQF--------LNKG------LSFICEKLLGRPLDKTEQCSVWDRRPLRC 657

  Fly   578 EQILYAAIDARCLMLIYNTLIERVSFIQAVIEKSIASNNFLRRGAHVK 625
            .|:.|||:||.|::|:|    |:.:.|.|.:  .|..|:|:.:.:.::
 Worm   658 LQLRYAAMDAYCMLLLY----EKCATIFAKL--GINVNDFVSKQSPIR 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nbr	NP_610094.1	mut-7_like_exo	413..599	CDD:176655	63/282 (22%)
Y57A10A.13	NP_496590.1	DnaQ_like_exo	432..677	CDD:447876	61/265 (23%)