Protein Alignment Nbr and exd3

DIOPT Version :10

• Sequence 1: NP_610094.1
• Gene: Nbr / 35385
• FlyBaseID: FBgn0032924
• Length: 625
• Species: Drosophila melanogaster
• Sequence 2: XP_031747378.1
• Gene: exd3 / 100494579
• XenbaseID: XB-GENE-6046956
• Length: 755
• Species: Xenopus tropicalis
• Alignment Length: 592
• Identity: 139/592 - (23%)
• Similarity: 252/592 - (42%)
• Gaps: 98/592 - (16%)

  Fly    68 NMYSKKKSPHLRQEFGRALMGHQDPLLLALKIFANCPDSSNIKTKSLSHFVLDTVCKLHKDFPHL 132
            ::::||....:||..|:.:...::||:..|.:.   ..:|..|.|..|..||     :..:|...
 Frog    20 SLWAKKDVLQIRQVVGQLISTLEEPLVALLDLL---EVTSTWKGKGNSLAVL-----IANEFQQW 76

  Fly   133 GEGCDPNTSMI------------AFNFVKTSGLLALNNAVIHAYSLRQI-RDLLLPKLRELLDNG 184
            .: .:|:...:            |.:.|....||.|   :...|.:.:. |..||.::..|..:|
 Frog    77 LK-ANPDARQVKSGLRLRKLQGRALSLVSEGQLLDL---LSDMYRIAEADRAFLLGQVTHLHRSG 137

  Fly   185 LYKEVTQWSISLQLTHEFDMLELAFPLIAIEKLPLAEEYLDHATQQRLPFVKFLDSLLHKEKSVL 249
            .|||....:..|.|..:.|:.|:..||:.:|:..|.|.|:....:.:...|:.||.......:..
 Frog   138 KYKEAAIMATRLGLQPDLDLEEMCTPLLFMERFNLVEAYVADYRELQCRLVQMLDGWSASNFNAR 202

  Fly   250 ELCEHLLDRYKNL-KISHNVLSYRPMAKIVARLAKKYGFDDAVTPNYKFTKTCSYLHYL-YREYE 312
            ::..    :|..| .:..:.|:.:.::::..:|.::|..|..:..|....:....|.|| |:.:.
 Frog   203 KVSR----QYIGLPPVKPDKLNMKTLSRLAFKLLERYNLDPVLCTNLLNQRHLGTLKYLMYKRFV 263

  Fly   313 KTRMNLASFREVVSVHA-----FNHELRTDFVKY--LASAGAHSEAIYWYTEFNIDPKDCP---- 366
            :..|...::.:.|....     ...:|.|..|:|  .|:||.      |...|.:..:..|
 Frog   264 EKSMTHENWTDHVQSTVGQSRWLQDQLITLLVRYSDCATAGR------WALHFGLPKETLPLAVA 322

  Fly   367 -----LEIETQVSQNGAGKASGWESPGKERCPSSRCDMYLTMDLPDECLIIVNKADEF----DRM 422
                 |.|:.|:|.|        |:...:  |.:|.:.:..:.:|.:.:..:..|.:.    :|:
 Frog   323 DSLEDLSIQDQLSAN--------ENVPDD--PQTRKEHFYQLPIPRDKIHFLRSAGDLSVCRERV 377

  Fly   423 LYHLQQECVIYLDSEW--MQSVCGDNQLCVLQIATGHNVYLIDCL----------ARESLRSEHW 475
            |...|   |:.:|.||  |....|...:.::|:|....|:|:|.|          ..:..|.|..
 Frog   378 LKDGQ---VVGVDMEWRPMFGGLGKQTVSLVQLALREEVFLLDLLQLNAPGAGANGTQRTREELI 439

  Fly   476 RLLGANIFNNVNIRKVGFSMVSDLSVLQRSLPLQLRLQ-MPHHYLDLRNLWLELKK-------QR 532
            |.: .::|....|.|:.:|::.|:..|:.:.|..|.|: .....|||..:..:|::       :|
 Frog   440 RFI-KDLFLCAAITKLSYSVLGDIQNLEATDPEFLGLEKQTRGILDLYTVHKQLQRVPHRPRGKR 503

  Fly   533 FGVEL----PFGNVNRAGDALTDLSLA---CLGKKLNKSNQCSNWANRPLRREQILYAAIDARCL 590
            ..|::    |......|..:...|||.   .|||.|:|:.|.|||..||||.:||||||.||.||
 Frog   504 EPVDVLADGPPSEDGLAPQSEKGLSLLVRDILGKPLDKTEQLSNWDKRPLREQQILYAAADAYCL 568

  Fly   591 MLIYNTL 597
            :.:|:.|
 Frog   569 LEVYDVL 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nbr	NP_610094.1	mut-7_like_exo	413..599	CDD:176655	64/216 (30%)
exd3	XP_031747378.1	DnaQ_like_exo	361..577	CDD:447876	64/219 (29%)
		Mut7-C	636..>730	CDD:473177