Protein Alignment Pld3 and PLD4

DIOPT Version :10

• Sequence 1: NP_610093.1
• Gene: Pld3 / 35384
• FlyBaseID: FBgn0032923
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001295103.1
• Gene: PLD4 / 122618
• HGNCID: 23792
• Length: 513
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 179/485 - (36%)
• Similarity: 273/485 - (56%)
• Gaps: 39/485 - (8%)

  Fly    36 RQAAGQQAGQMVTVSLFMLLFLGS----------------SYFQPR--PRLHQYKGGRGHGLLE- 81
            |:...::||.:..:....:|:|||                ...||:  ||..::........||
Human    28 RRPWDREAGTLQVLGALAVLWLGSVALICLLWQVPRPPTWGQVQPKDVPRSWEHGSSPAWEPLEA 92

  Fly    82 -----KFDCNIQLVESIPIGLTYPDGSPRFLSTYEAWLELLESATTSLDIASFYWTLKAEDTPGV 141
                 :..|.:.||||||..|....|||......:|||:||::|..|:.:||:||:|...|. ||
Human    93 EARQQRDSCQLVLVESIPQDLPSAAGSPSAQPLGQAWLQLLDTAQESVHVASYYWSLTGPDI-GV 156

  Fly   142 SDNSTRPGEDVFARL--LANGNGGSRSPRIKIRIAQSEPSSGTPNLNTKLLASAGAAEVVSISFP 204
            :|:|::.||.:..:|  |...|       |.:.:|.|.|:....:.:.::||:.| |.|..:...
Human   157 NDSSSQLGEALLQKLQQLLGRN-------ISLAVATSSPTLARTSTDLQVLAARG-AHVRQVPMG 213

  Fly   205 KYFGSGVLHTKLWVVDNKHFYLGSANMDWRALTQVKEMGVLVQNCPELTHDVAKIFGEYWYLGNS 269
            : ...||||:|.||||.:|.|:||||||||:||||||:|.::.||..|..|:.|.|..||.||..
Human   214 R-LTRGVLHSKFWVVDGRHIYMGSANMDWRSLTQVKELGAVIYNCSHLAQDLEKTFQTYWVLGVP 277

  Fly   270 ESSRIPDWDWRYATSYNLKHPMQLSVNKNTSIEGFLSSSPPPLSPSGRTDDLNAILNTINTAITY 334
            ::.....|...:::.:|...|.. .:........:.|:|||.|.|.|||.||.|:|..:.:|..:
Human   278 KAVLPKTWPQNFSSHFNRFQPFH-GLFDGVPTTAYFSASPPALCPQGRTRDLEALLAVMGSAQEF 341

  Fly   335 VNIAVMDYYPLIIYEKNHHYWPFIDDALRKAAVERGVAVKLLISWWKHSNPSEDRYLRSLQDLAS 399
            :..:||:|:|...:.....|||.:|:|||.||..:||.|:||:....:::|:...||||||.|::
Human   342 IYASVMEYFPTTRFSHPPRYWPVLDNALRAAAFGKGVRVRLLVGCGLNTDPTMFPYLRSLQALSN 406

  Fly   400 KEDKIDIQIRRFIVPTDSSQEKIPFGRVNHNKYMVTDRVAYIGTSNWSGDYFTDTAGIGLVLSET 464
            ....:.:.::.||||. .:...|||.||||:|:|||::.|||||||||.|||:.|||:|||::::
Human   407 PAANVSVDVKVFIVPV-GNHSNIPFSRVNHSKFMVTEKAAYIGTSNWSEDYFSSTAGVGLVVTQS 470

  Fly   465 FETETTN-TLRSDLRNVFERDWNSKYATPL 493
            ...:... |::..||.:|||||:|:||..|
Human   471 PGAQPAGATVQEQLRQLFERDWSSRYAVGL 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pld3	NP_610093.1	PHA02820	89..493	CDD:222934	164/406 (40%)
PLD4	NP_001295103.1	PLDc_vPLD4_1	105..274	CDD:197243	75/178 (42%)
		PLDc_vPLD4_2	311..497	CDD:197246	82/186 (44%)