DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and E2F1

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_568413.1	Gene:	E2F1 / 832283	AraportID:	AT5G22220	Length:	469	Species:	Arabidopsis thaliana

Alignment Length:	402	Identity:	107/402 - (26%)
Similarity:	188/402 - (46%)	Gaps:	83/402 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KRKT---ASIVKRDSSAAGTTSSAMMMKVDSAETSVRS-QSYESTPVSMDTSPDPPTPIKSPSNS 63
            ||||   ..||:.:....|...:.:..|...|:.:.|| :|.:|..::..::..      ||.|:
plant    63 KRKTDLVNQIVEVNELNTGVLQTPVSGKGGKAKKTSRSAKSNKSGTLASGSNAG------SPGNN 121

  Fly    64 QSQSQPGQQRSVGSLVLLTQKFVDLVK-ANEGSIDLKAATKILDVQKRRIYDITNVLEGIGLIDK 127
            .:|:  |..|...||.|||:||::|:| |.:|.:||..|...|:|||||||||||||||||||:|
plant   122 FAQA--GTCRYDSSLGLLTKKFINLIKQAEDGILDLNKAADTLEVQKRRIYDITNVLEGIGLIEK 184

  Fly   128 GRHCSLVRWRGGGFNNAKDQENYDLARSRTNHLKML---EDDLDRQLEYAQRNLRYVMQDPSNRS 189
            ... :.::|:  |.:.:|..|..:...:..:.::.|   |..||.|:..:|..|..:.:|.:|:.
plant   185 TLK-NRIQWK--GLDVSKPGETIESIANLQDEVQNLAAEEARLDDQIRESQERLTSLSEDENNKR 246

  Fly   190 YAYVTRDDLLDIFGDDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDI-------------RLV 241
            ..:||.:|:.:         :|.:       :|...:||...:|:.:::             |::
plant   247 LLFVTENDIKN---------LPCF-------QNKTLIAVKAPHGTTLEVPDPDEAGGYQRRYRII 295

  Fly   242 TNQGKSTTNPHDV-------DGFFDYHRLDTPS--PSTSSHSSE-DGNAPACAGNVITDEHGYSC 296
            .   :||..|.||       :.|.|..:.|.||  |...|:..: ..|.|:.:|  :.:.|..|.
plant   296 L---RSTMGPIDVYLVSQFEESFEDIPQADEPSNVPDEPSNVPDVPSNLPSTSG--LPENHDVSM 355

  Fly   297 NPGMKDEMKLLENELTAKIIFQNYLSGHSLRRFYPDDPNLEN----PPLLQLNPPQEDF--NFAL 355
              .||:|.  .|..:..:.:       ...:|.|.|   :|:    ..::::.||..|.  ::..
plant   356 --PMKEES--TERNMETQEV-------DDTQRVYSD---IESHDFVDGIMKIVPPDLDMGVDYWF 406

  Fly   356 KSDEGICELFDV 367
            :|:.|...:.|:
plant   407 RSEVGEVSITDM 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	36/61 (59%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	13/61 (21%)
E2F1	NP_568413.1	E2F_TDP	131..194	CDD:396755	36/65 (55%)
E2F1	NP_568413.1	E2F_DD	205..310	CDD:271137	23/123 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1472
Inparanoid	1	1.050	96	1.000	Inparanoid score	I2215
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12081
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.930