DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and E2F3

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_973610.1	Gene:	E2F3 / 818174	AraportID:	AT2G36010	Length:	514	Species:	Arabidopsis thaliana

Alignment Length:	393	Identity:	87/393 - (22%)
Similarity:	151/393 - (38%)	Gaps:	108/393 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 SAMMMKVDSAETSVRSQSYESTPVSMDTSPDPPTPI----KSPSNSQSQSQPGQQRSVGSLV--- 79
            :.|.|.|..:.....|..:.:.|.|...:|.....:    |:..|..:...|....:|.|..
plant   148 ATMDMVVAPSNNGFTSSGFTNIPSSPCQTPRKGGRVNIKSKAKGNKSTPQTPISTNAVRSFYEIS 212

  Fly    80 -------LLTQKFVDLVK-ANEGSIDLKAATKILDVQKRRIYDITNVLEGIGLIDKGRHCSLVRW 136
                   |||:|||:|:| |.:|.:||..|.:.|:||||||||||||||||.||:| ...:.:.|
plant   213 FMSRVTSLLTKKFVNLIKQAKDGMLDLNKAAETLEVQKRRIYDITNVLEGIDLIEK-PFKNRILW 276

  Fly   137 RGGGFNNAKDQENYDLA----RSRTNHLKMLEDDLDRQLEYAQRNLRYVMQDPSNRSYAYVTRDD 197
            :  |.:.....|:.|::    ::...:|.:.|..||.|:.                 :.:||.:|
plant   277 K--GVDACPGDEDADVSVLQLQAEIENLALEEQALDNQIR-----------------WLFVTEED 322

  Fly   198 LLDIFG------------DDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDIRLVTN-QGK--- 246
            :..:.|            ..:...:|:.||..|..:..|.:.:....| .||:.||:. :||
plant   323 IKSLPGFQNQTLIAVKAPHGTTLEVPDPDEAADHPQRRYRIILRSTMG-PIDVYLVSEFEGKFED 386

  Fly   247 ------------------STTNPHDVDGFFDYHRLDTPSPSTSSHSSEDGNAPACAGNVITDEHG 293
                              .:|..||::.      |...:|.|:               :::.:|.
plant   387 TNGSGAAPPACLPIASSSGSTGHHDIEA------LTVDNPETA---------------IVSHDHP 430

  Fly   294 YSCNPGMKDEMKLLENELTAKIIFQNYLSGHSLRRFYPDDPNLENPPLLQLNPPQEDFNFALKSD 358
            :. .||...::..|:.::...:            :..|.|...:......|:..:.......|:|
plant   431 HP-QPGDTSDLNYLQEQVGGML------------KITPSDVENDESDYWLLSNAEISMTDIWKTD 482

  Fly   359 EGI 361
            .||
plant   483 SGI 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	35/71 (49%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	12/70 (17%)
E2F3	NP_973610.1	E2F_TDP	219..278	CDD:280479	34/61 (56%)
E2F3	NP_973610.1	E2F_CC-MB	295..378	CDD:293030	18/100 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	96	1.000	Inparanoid score	I2215
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12081
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.930