DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f2 and E2F8

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001243300.1	Gene:	E2F8 / 79733	HGNCID:	24727	Length:	867	Species:	Homo sapiens

Alignment Length:	170	Identity:	45/170 - (26%)
Similarity:	67/170 - (39%)	Gaps:	46/170 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KTASIVKRDSSAAGTTSSAMMMKVDSAETS---VRSQSYESTPVSMDTSPD----------PPTP 56
            ||...:|............||:|....|..   ::|.|.|...:..:|.|:          |...
Human   188 KTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFIKSYSIEDHIIKSNTGPNGHPDMCFVELPGVE 252

  Fly    57 IKSPS-NSQSQSQPGQQRSVGSLVLLTQKFVDLVKANEGSI-DLKAATKIL-------DVQK--- 109
            .::.| ||:...         ||.:::||||.|...:...| .|:.|.|||       |:.|
Human   253 FRAASVNSRKDK---------SLRVMSQKFVMLFLVSTPQIVSLEVAAKILIGEDHVEDLDKSKF 308

  Fly   110 ----RRIYDITNVLEGIGLI-------DKGRHCSLVRWRG 138
                ||:|||.|||..:.||       ::||..:. :|.|
Human   309 KTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAF-KWTG 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	28/82 (34%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549
E2F8	NP_001243300.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..58
		E2F_TDP	114..182	CDD:308118
		E2F_TDP	262..347	CDD:308118	28/94 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	408..432
		Atrophin-1	<464..700	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..616
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	771..800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810