DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and e2f6

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	XP_005160782.1	Gene:	e2f6 / 560495	ZFINID:	ZDB-GENE-030131-513	Length:	406	Species:	Danio rerio

Alignment Length:	270	Identity:	70/270 - (25%)
Similarity:	122/270 - (45%)	Gaps:	35/270 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VKRDSSAAGTTSSAMMMKVDSAETSVRSQSYESTPVSMDTSPDPPTPIKSPSNSQSQSQPGQQRS 74
            :..|:::..|.|...       |.|| :||:.  |:.  :||....|:....:..:...|  .||
Zfish   133 IPADNNSNSTISKPQ-------EQSV-TQSFR--PIF--SSPTILPPVNVADDVFNSKAP--HRS 183

  Fly    75 VGSLVLLTQKFVDLVK-ANEGSIDLKAATKILDVQKRRIYDITNVLEGIGLIDKGRHCSLVRWRG 138
            ..:|..||::|:.|:. |.||.:||...::.|..:|||:||||:||.||.|:.|... :.::|..
Zfish   184 EVALGQLTKRFMQLLNAAPEGVLDLNEVSRKLGARKRRVYDITSVLAGIHLLKKTSK-NKIQWMS 247

  Fly   139 GGFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEYAQRNLRYVMQDPSNRSYAYVTRDDL--LDI 201
            ....::...:....|::...|||..|:.||..::...:.|..:.....|...||||.:|:  :|:
Zfish   248 STPLSSFGSQWSPKAKAELLHLKSTEEALDWLIKDCAQQLFALTDLKDNADSAYVTYEDICQIDV 312

  Fly   202 FGDDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDIRLVTNQGKSTTNPHDVDGFFDYHRLDTP 266
            |.|.::..|...:|.        :|.|......:|.|.|..::|...|...:.:|         |
Zfish   313 FKDQTIIAIRAPEET--------KLEVPTPTEESIKIHLKGSRGPIHTLTCETEG---------P 360

  Fly   267 SPSTSSHSSE 276
            ..:..|.::|
Zfish   361 GDAEDSSNTE 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	25/61 (41%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	18/60 (30%)
e2f6	XP_005160782.1	THAP	3..79	CDD:283206
		E2F_TDP	187..246	CDD:280479	24/59 (41%)
		E2F_DD	263..358	CDD:271137	25/102 (25%)
		coiled coil	263..292	CDD:271137	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820