DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and E2f7

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001345489.1	Gene:	E2f7 / 52679	MGIID:	1289147	Length:	904	Species:	Mus musculus

Alignment Length:	284	Identity:	70/284 - (24%)
Similarity:	101/284 - (35%)	Gaps:	70/284 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DTSPDPPTP-IKSPSNSQSQSQPGQQRSVGSLVLLTQKFVDLVKANEGSI-DLKAATKIL----- 105
            |.||||..| :...|.:...|.....|...||.:::||||.|...::..| .|..|.|||
Mouse   257 DGSPDPRDPHLLDFSEADYPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQ 321

  Fly   106 ---DVQK-----RRIYDITNVLEGIGLI-------DKGRHCSLVRWRGGGFNNAKDQENYDLARS 155
               |..|     ||:|||.|||..:.||       ::||..:. :|.|....::.|:|..|::.|
Mouse   322 DTPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAF-KWIGPVDFSSIDEELLDVSAS 385

  Fly   156 RTNHLK------MLEDDLDRQLEYAQRNL--------RYVMQDPSN--------------RSYAY 192
            ....||      :.....:|.:.|...|.        |.|..:||:              .|.|.
Mouse   386 ILPELKKEAYGQIRVCAKERLVRYGSFNTVHTSEKIQRKVSSEPSSPQGERQGSAYSLEIGSLAA 450

  Fly   193 VTRDDLLDIFGDDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDIRLVTNQGKSTTNPHDVDGF 257
            :.|..:.|           |..||..:.......|..||...::|.....   |....|     .
Mouse   451 IYRQKVED-----------NSQEEAFVSNTAVPPASILDPALSMDSEYCV---KPLAQP-----V 496

  Fly   258 FDYHRLDTPSPSTSSHSSEDGNAP 281
            |...:.|.|:.|..:..|.....|
Mouse   497 FSVAQTDLPAFSAQNGPSGQVGVP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	28/81 (35%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	16/86 (19%)
E2f7	NP_001345489.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	61..80
		E2F_TDP	144..212	CDD:308118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	252..283		8/25 (32%)
		E2F_TDP	284..368	CDD:308118	28/84 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..628
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	846..904
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810