DRSC/TRiP Functional Genomics Resources

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Protein Alignment E2f2 and E2f6

DIOPT Version :10

Sequence 1:NP_477355.1 Gene:E2f2 / 35381 FlyBaseID:FBgn0024371 Length:370 Species:Drosophila melanogaster
Sequence 2:NP_150373.2 Gene:E2f6 / 50496 MGIID:1354159 Length:272 Species:Mus musculus


Alignment Length:310 Identity:90/310 - (29%)
Similarity:134/310 - (43%) Gaps:74/310 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MYKRKTASIVKRDSSAAGTTSSAMMMKVDSAETSVRSQSYESTPVSMDTSPDPPTPIKSPSNSQS 65
            |.:::||   :|..|          :.||.|:.:||.:..:  |::::........|....|.|.
Mouse     1 MSQQRTA---RRQPS----------LLVDPAQETVRRRCRD--PINVENLLPSKIRINLEENVQY 50

  Fly    66 QS-----QPGQQRSVGSLVLLTQKFVDLVKANEGSI-DL-KAATKILDVQKRRIYDITNVLEGIG 123
            .|     :..:.|...|||.||:||:|||::..|.| || |.||| |.|:|||:|||||||:||.
Mouse    51 VSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATK-LGVRKRRVYDITNVLDGIE 114

  Fly   124 LIDKGRHCSLVRWRGGGFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEYAQRNLRYVMQDPSNR 188
            |::| :..:.:||.|...||..........::..:.|..:||.||..::...:.|..:..|..|.
Mouse   115 LVEK-KSKNHIRWIGSDLNNFGAAPQQKKLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENE 178

  Fly   189 SYAYVTRDDLLDIFGDDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDIRL-----VTNQGKST 248
            ..||||..|         :..|..:.|::.|       ||.....:.:|:..     :|...:||
Mouse   179 RLAYVTYQD---------IHGIQAFHEQIVI-------AVKAPEETRLDVPAPREDSITVHIRST 227

  Fly   249 TNPHDV---------------DGFFDYHRLDTPSPSTSSHSSEDGNAPAC 283
            ..|.||               ||.       ..|||.|||       |.|
Mouse   228 KGPIDVYLCEVEQNHSNGKTNDGI-------GASPSKSSH-------PQC 263

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E2f2NP_477355.1 E2F_TDP 77..138 CDD:460530 36/62 (58%)
E2F_DD 159..>218 CDD:473951 15/58 (26%)
E2f6NP_150373.2 Binding to corepressors. /evidence=ECO:0000305 1..62 15/75 (20%)
E2F_TDP 64..128 CDD:460530 36/65 (55%)
DEF box 95..129 19/35 (54%)
Dimerization. /evidence=ECO:0000255 130..222 21/107 (20%)
E2F_DD 139..239 CDD:271137 25/115 (22%)
coiled coil 139..173 CDD:271137 6/33 (18%)
Leucine-zipper 143..164 5/20 (25%)
Transcription repression. /evidence=ECO:0000250 173..272 29/121 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..272 10/36 (28%)

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