DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and e2f5

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001184229.1	Gene:	e2f5 / 402908	ZFINID:	ZDB-GENE-030828-3	Length:	363	Species:	Danio rerio

Alignment Length:	364	Identity:	114/364 - (31%)
Similarity:	176/364 - (48%)	Gaps:	64/364 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 SNSQS--QSQP-GQQRSVGSLVLLTQKFVDLV-KANEGSIDLKAATKILDV-QKRRIYDITNVLE 120
            |||.|  .|.| |..|...||.|||.|||.|: :|.:|.:|||.|...|.| |||||||||||||
Zfish     4 SNSASFPHSTPNGSSRHEKSLGLLTVKFVTLLQEAKDGVLDLKVAADSLAVKQKRRIYDITNVLE 68

  Fly   121 GIGLIDKGRHCSLVRWRG--GGFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEYAQRNLRYVMQ 183
            |||||:| :..:.::|:|  .|....:..|..:|.::....|::.|.:||.|....|::::.:.:
Zfish    69 GIGLIEK-KTKNTIQWKGESTGCQPQEVLEQVELLKANIADLELQERELDMQKACLQQSIKQLNE 132

  Fly   184 DPSNRSYAYVTRDDLLDIFGDDSVFTI--PNYDE-EVDIK------RNHYELAVSLDNGSA-IDI 238
            ||.:..|:||..:|:.|.|..|::..:  |:..: ||.:.      :..|:  |:|.:.|| |.:
Zfish   133 DPYSCRYSYVMHEDICDAFSGDTLLAVMAPSGTQLEVPVPEMGHNGQKKYQ--VNLRSHSAPIQV 195

  Fly   239 RLVTNQGKSTTNP--HDVDGFFDYHRLDTPSPSTSSHSSEDGNAPACAGNVITDEHG-------- 293
            .|: |:..|.:.|  ..|....|...:.|| |||.:...   ..|..:.::...:||
Zfish   196 MLI-NRETSCSKPVVVSVPPIDDISSMPTP-PSTPAGLQ---RFPISSIDLCDQKHGLLKSPAAE 255

  Fly   294 -------------YSCNP-GMKDEMKLLENELTAKIIFQNYLSGHSLRRFYPD------------ 332
                         ..||| ....:..|:::.|......|..|.|..|:....:
Zfish   256 HQLTPSSTSPDVHMECNPESPASQCLLMQSSLGGPEEQQRELGGQDLQSMLEEMRDEREGVSNLI 320

  Fly   333 DPNLENP--PLLQLNP-PQEDFNFALKSDEGICELFDVQ 368
            |..:.:.  |||:|:| |..|::|.|..:||:|:|||||
Zfish   321 DELMSSDVFPLLRLSPNPGVDYSFNLDDNEGVCDLFDVQ 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	37/62 (60%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	17/61 (28%)
e2f5	NP_001184229.1	E2F_TDP	21..85	CDD:280479	37/64 (58%)
		COG5665	74..>328	CDD:227952	54/261 (21%)
		E2F_DD	97..201	CDD:271137	28/106 (26%)
		coiled coil	97..132	CDD:271137	8/34 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1472
Inparanoid	1	1.050	125	1.000	Inparanoid score	I4681
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3254
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.960