DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f2 and E2f1

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001094248.1	Gene:	E2f1 / 399489	RGDID:	728892	Length:	432	Species:	Rattus norvegicus

Alignment Length:	390	Identity:	102/390 - (26%)
Similarity:	156/390 - (40%)	Gaps:	98/390 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 STPVSMDTSPDPP------TPIKSPSNSQSQSQ----------------------PGQQ-RSVGS 77
            :||.:...:|..|      .|:|...:.::..|                      ||:: |...|
  Rat    65 ATPQAPRPAPSAPRPALGRPPVKRRLDLETDHQYLAGSSGPFRGRGRHPGKGVKSPGEKSRYETS 129

  Fly    78 LVLLTQKFVDLVK-ANEGSIDLKAATKILDVQKRRIYDITNVLEGIGLIDKGRHCSLVRWRGG-- 139
            |.|.|::|::|:. :.:|.:||..|.::|.||||||||||||||||.||.| :..:.::|.|.
  Rat   130 LNLTTKRFLELLSHSADGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAK-KSKNHIQWLGSRT 193

  Fly   140 --GFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEYAQRNLRYVMQDPSNRSYAYVTRDDLLDIF 202
              |.....:....||     ..|:..|..||..:......|:.:.:|...:..||||..||..|
  Rat   194 MVGIGQRLEGLTQDL-----QQLQESEQQLDHLMHICTTQLQLLSEDSDIQRLAYVTCQDLRSI- 252

  Fly   203 GDDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDIRLVTNQGKSTTNPHDV--------DGFFD 259
                  ..|.....:.||........::|:.....|.|.:.||     |.||        :|.
  Rat   253 ------ADPAEQMVIVIKAPPETQLQAVDSAETFQISLKSKQG-----PIDVFLCPEESAEGI-- 304

  Fly   260 YHRLDTPSPSTSSH---SSEDGNAPACAGNVITDEHGYSCNP---------GMKDEMKL------ 306
                   ||..:|:   |.||.||.  :|.........|.:|         |::.|..|
  Rat   305 -------SPGRTSYQETSGEDRNAD--SGTAGPPPSPPSTSPTLDPSQSLLGLEQEAVLPRIGNL 360

  Fly   307 ---LENELTAKIIFQNYLSGHSLRRFYPDDPNLENPPLLQLNPPQE--DFNFALKSDEGICELFD 366
               :|.:..:.::..:.|..|....|    ..|.....:.|:||.|  |::|.|:..|||.:|||
  Rat   361 RAPMEEDRLSPLVAADSLLEHVKEDF----SGLLPGEFISLSPPHEAVDYHFGLEEGEGIRDLFD 421

Fly 367 366
Rat 422 421

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	31/61 (51%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	14/58 (24%)
E2f1	NP_001094248.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..85		4/19 (21%)
		Cyclin A:CDK2 binding. /evidence=ECO:0000250\|UniProtKB:Q01094	65..106		7/40 (18%)
		Interaction with BIRC2/c-IAP1. /evidence=ECO:0000250\|UniProtKB:Q01094	87..189		35/102 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..126		2/27 (7%)
		E2F_TDP	127..190	CDD:396755	31/63 (49%)
		Leucine-zipper. /evidence=ECO:0000250\|UniProtKB:Q01094	151..172		14/20 (70%)
		DEF box. /evidence=ECO:0000250\|UniProtKB:Q01094	156..192		22/36 (61%)
		Required for interaction with TRIM28. /evidence=ECO:0000250\|UniProtKB:Q01094	190..377		44/214 (21%)
		Dimerization. /evidence=ECO:0000255	193..282		20/100 (20%)
		E2F_DD	219..299	CDD:271137	21/91 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..342		12/55 (22%)
		Transactivation. /evidence=ECO:0000250\|UniProtKB:Q01094	363..432		18/63 (29%)
		RB1 binding. /evidence=ECO:0000250\|UniProtKB:Q01094	404..421		7/16 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820