DRSC/TRiP Functional Genomics Resources

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Protein Alignment E2f2 and E2F5

DIOPT Version :10

Sequence 1:NP_477355.1 Gene:E2f2 / 35381 FlyBaseID:FBgn0024371 Length:370 Species:Drosophila melanogaster
Sequence 2:NP_001942.2 Gene:E2F5 / 1875 HGNCID:3119 Length:346 Species:Homo sapiens


Alignment Length:63 Identity:20/63 - (31%)
Similarity:26/63 - (41%) Gaps:21/63 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 KLFHEEATQYYVKCTHLFHYEPAQCPALLLVSKT----------DPVGTEKANNRLRSIWESV 54
            |.|.:.||  :..|..|         .||.||:|          :|.|||.|:..|.|..:||
Human   113 KNFRKNAT--WENCDDL---------GLLGVSETHFISLLGQEKEPSGTETASTNLFSGQQSV 164

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E2f2NP_477355.1 E2F_TDP 77..138 CDD:460530
E2F_DD 159..>218 CDD:473951
E2F5NP_001942.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52
E2F_TDP 51..116 CDD:460530 1/2 (50%)
Leucine-zipper 76..98
DEF box 81..118 2/4 (50%)
Dimerization. /evidence=ECO:0000255 119..215 18/57 (32%)
E2F_DD 128..232 CDD:271137 14/37 (38%)
coiled coil 128..163 CDD:271137 12/34 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 236..295
Transactivation. /evidence=ECO:0000255 287..346
RBL2 association. /evidence=ECO:0000255 323..340
Blue background indicates that the domain is not in the aligned region.

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