DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f2 and E2F1

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_005216.1	Gene:	E2F1 / 1869	HGNCID:	3113	Length:	437	Species:	Homo sapiens

Alignment Length:	360	Identity:	96/360 - (26%)
Similarity:	151/360 - (41%)	Gaps:	70/360 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ESTPVSMDTSPDPPTPIKSPSNSQSQSQPGQQRSVGSLVLLTQKFVDLVK-ANEGSIDLKAATKI 104
            ||:..:......|...:|||..        :.|...||.|.|::|::|:. :.:|.:||..|.::
Human   103 ESSGPARGRGRHPGKGVKSPGE--------KSRYETSLNLTTKRFLELLSHSADGVVDLNWAAEV 159

  Fly   105 LDVQKRRIYDITNVLEGIGLIDKGRHCSLVRWRGG----GFNNAKDQENYDLARSRTNHLKMLED 165
            |.||||||||||||||||.||.| :..:.::|.|.    |.....:....||     ..|:..|.
Human   160 LKVQKRRIYDITNVLEGIQLIAK-KSKNHIQWLGSHTTVGVGGRLEGLTQDL-----RQLQESEQ 218

  Fly   166 DLDRQLEYAQRNLRYVMQDPSNRSYAYVTRDDLLDIF--GDDSVFTIPNYDE----EVDIKRNHY 224
            .||..:......||.:.:|..::..||||..||..|.  .:..|..|....|    .||...| :
Human   219 QLDHLMNICTTQLRLLSEDTDSQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAVDSSEN-F 282

  Fly   225 ELAVSLDNGSAIDIRLVTNQGKSTTNPHDVDGFFDYHRLDTPSPSTSSHSSEDGNA--------- 280
            ::::....| .||:.|...:.....:|             ..:||....|.|:..|
Human   283 QISLKSKQG-PIDVFLCPEETVGGISP-------------GKTPSQEVTSEEENRATDSATIVSP 333

  Fly   281 -PACAGNVITDEHGYSCNPGMKDEMKLLENELTAKI------IFQNYLS----GHSLRRFYPDD- 333
             |:...:.:|.:...|.       :.|.:..|.:::      :.::.||    ..||.....:|
Human   334 PPSSPPSSLTTDPSQSL-------LSLEQEPLLSRMGSLRAPVDEDRLSPLVAADSLLEHVREDF 391

  Fly   334 PNLENPPLLQLNPPQE--DFNFALKSDEGICELFD 366
            ..|.....:.|:||.|  |::|.|:..|||.:|||
Human   392 SGLLPEEFISLSPPHEALDYHFGLEEGEGIRDLFD 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	31/61 (51%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	17/64 (27%)
E2F1	NP_005216.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..87
		Cyclin A:CDK2 binding. /evidence=ECO:0000269\|PubMed:8033208	67..108		2/4 (50%)
		Interaction with BIRC2/c-IAP1. /evidence=ECO:0000269\|PubMed:21653699	89..191		37/96 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..128		6/32 (19%)
		E2F_TDP	129..192	CDD:280479	31/63 (49%)
		Leucine-zipper	153..174		14/20 (70%)
		DEF box	158..194		22/36 (61%)
		Required for interaction with TRIM28. /evidence=ECO:0000269\|PubMed:17704056	192..382		41/216 (19%)
		Dimerization. /evidence=ECO:0000255	195..284		23/94 (24%)
		E2F_DD	202..301	CDD:271137	26/105 (25%)
		coiled coil	202..236	CDD:271137	8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..349		8/61 (13%)
		Transactivation	368..437		19/59 (32%)
		RB1 binding. /evidence=ECO:0000269\|PubMed:12598654	409..426		7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3254
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850