DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and E2F7

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_976328.2	Gene:	E2F7 / 144455	HGNCID:	23820	Length:	911	Species:	Homo sapiens

Alignment Length:	314	Identity:	78/314 - (24%)
Similarity:	118/314 - (37%)	Gaps:	102/314 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TSPDPPTPIKSPSNSQSQSQPGQQRSVGSLVLLTQKFVDLVKANEGSI-DLKAATKIL------- 105
            :.||.|:   |.:||:...         ||.:::||||.|...::..| .|..|.|||
Human   270 SEPDCPS---SSANSRKDK---------SLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDA 322

  Fly   106 -DVQK-----RRIYDITNVLEGIGLI-------DKGRHCSLVRWRGGGFNNAKDQENYDLARSRT 157
             |..|     ||:|||.|||..:.||       ::||..:. :|.|....::.|:|..|::.|..
Human   323 PDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAF-KWIGPVDFSSSDEELVDVSASVL 386

  Fly   158 NHLK---------MLEDDLDRQ-----LEYAQRNLRYVMQDPSNRSYAYVTRDDLLDIFGDDSVF 208
            ..||         ..:..|.|.     ::.::|..|.|..:||:
Human   387 PELKRETYGQIQVCAKQKLARHGSFNTVQASERIQRKVNSEPSS--------------------- 430

  Fly   209 TIPNYDEEVDIKRNHYELAVSLDNGSAIDI---RLVTN-QGKSTTNPHDVDGFFDYHRLDTPSPS 269
               .|.||      ......||:.||...:   ::..| |||:          |...|:..||
Human   431 ---PYREE------QGSGGYSLEIGSLAAVYRQKIEDNSQGKA----------FASKRVVPPS-- 474

  Fly   270 TSSHSSEDGNAPACAGNVITDEHGYSCNPGMKDEMKLLENELTAKIIFQNYLSG 323
                ||.|..||.   .|::.:..|..||.......:.:.:|.| ...||.|:|
Human   475 ----SSLDPVAPF---PVLSVDPEYCVNPLAHPVFSVAQTDLQA-FSMQNGLNG 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	28/81 (35%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	12/72 (17%)
E2F7	NP_976328.2	E2F_TDP	144..211	CDD:280479
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..283		6/15 (40%)
		E2F_TDP	284..367	CDD:280479	28/92 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..438		8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..645
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	672..701
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	860..911
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810