DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and E2f5

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_031918.2	Gene:	E2f5 / 13559	MGIID:	105091	Length:	335	Species:	Mus musculus

Alignment Length:	349	Identity:	109/349 - (31%)
Similarity:	169/349 - (48%)	Gaps:	53/349 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 TSPDPPTP---IKSPSNSQSQSQP------GQQRSVGSLVLLTQKFVDLV-KANEGSIDLKAATK 103
            ||...|||   .:.|.:....|||      |..|...||.|||.|||.|: :|.:|.:|||||..
Mouse     7 TSSAQPTPQAQAQPPPHGAPSSQPSAALAGGSSRHEKSLGLLTTKFVSLLQEAQDGVLDLKAAAD 71

  Fly   104 ILDV-QKRRIYDITNVLEGIGLIDKGRHCSLVRWR--GGGFNNAKDQENYDLARSRTNHLKMLED 165
            .|.| |||||||||||||||.||:| :..:.::|:  |.|.|..:..:.....::....|::.|.
Mouse    72 TLAVRQKRRIYDITNVLEGIDLIEK-KSKNSIQWKGVGAGCNTKEVIDRLRCLKAEIEDLELKER 135

  Fly   166 DLDRQLEYAQRNLRYVMQDPSNRSYAYVTRDDLLDIFGDDSVFTI--PNYDE-EVDIK------R 221
            :||:|..:.|::::.||:|..|..::|||.:|:.:.|..|::..|  |:..: ||.|.      :
Mouse   136 ELDQQKLWLQQSIKNVMEDSINNRFSYVTHEDICNCFHGDTLLAIQAPSGTQLEVPIPEMGQNGQ 200

  Fly   222 NHYELAVSLDNGSAIDIRLVTNQGKST------TNPHDVDGFFDYHRLDTPSPSTSSHSSEDGNA 280
            ..|::.:...:| .|.:.|:..:..|:      ..|.|          |...||:.|.:|.....
Mouse   201 KKYQINLKSHSG-PIHVLLINKESSSSKPVVFPVPPPD----------DLTQPSSQSSTSVTPQK 254

  Fly   281 PACAGNVITDEHGYSCNPGMKDEMKLLENELTAKIIFQNYLSGHSLRRFYPDDPNLENPPLLQLN 345
            ...|...:.::|        ..|......:..|..:....:||..:......|..    |||:|:
Mouse   255 STMAAQNLPEQH--------VSERSQTFQQTPAAEVSSGSISGDIIDELMSSDVF----PLLRLS 307

  Fly   346 P-PQEDFNFALKSDEGICELFDVQ 368
            | |.:|:||.|..:||:|:|||||
Mouse   308 PTPADDYNFNLDDNEGVCDLFDVQ 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	37/64 (58%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	19/61 (31%)
E2f5	NP_031918.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..40		10/32 (31%)
		Gly-rich_Ago1	<7..60	CDD:289530	20/52 (38%)
		E2F_TDP	42..106	CDD:280479	37/64 (58%)
		Leucine-zipper	66..88		16/21 (76%)
		DEF box	71..108		21/37 (57%)
		Dimerization. /evidence=ECO:0000255	109..205		24/95 (25%)
		E2F_DD	118..222	CDD:271137	25/104 (24%)
		coiled coil	118..153	CDD:271137	7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..285		11/76 (14%)
		Transactivation. /evidence=ECO:0000255	277..335		22/59 (37%)
		RBL2 association. /evidence=ECO:0000255	312..329		8/16 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H1472
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020