DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f2 and E2f8

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001013386.2	Gene:	E2f8 / 108961	MGIID:	1922038	Length:	860	Species:	Mus musculus

Alignment Length:	378	Identity:	72/378 - (19%)
Similarity:	136/378 - (35%)	Gaps:	115/378 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TTSSAMMMKVDSAETSVRSQSYE--------STPVSMDTSPDPPTPIKSPSNSQSQSQPGQQRSV 75
            |.::.:.|.:.:....:||:..:        :.|.:.|...:     ....:...:|||.::..
Mouse    58 TPTANLKMLISAVSPEIRSRDQKRGLSDNRSALPEARDCLHE-----HLSGDEFEKSQPSRKEK- 116

  Fly    76 GSLVLLTQKFVDLV-----KANEGSIDLKAATKILDVQKRRIYDITNVLEGIGLIDK-------- 127
             ||.||..||:...     .|....|.|....:.|:|::||||||.||||.:.::.:
Mouse   117 -SLGLLCHKFLARYPKYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTW 180

  Fly   128 -GRHCSLVRWRG-----GGFNNAKDQ----------ENYDLARS-------------RTNHLKML 163
             ||| :|.:..|     |..|...:|          :.:|..:|             :..|..|.
Mouse   181 HGRH-NLTKTLGTLKSVGEENKYAEQIMMIKRKEYEQEFDFIKSCGIEDHVIKSHTGQNGHSDMC 244

  Fly   164 EDDL--------------DRQLEYAQRN--LRYVMQDPSNRSYAYVTRDDLLDIFGDDSVFTIPN 212
            ..:|              |:.|....:.  :.:::..|...|.....:    .:.|:|.|..:..
Mouse   245 FVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEIAAK----ILIGEDHVEDLDK 305

  Fly   213 YDEEVDIKRNHYELAVSLDNGSAID----IRLVTNQGKST----TNPHDVDGFFDYHRLDTPSPS 269
            ...:..|:| .|::|..|   |::|    :.:...:|:..    |.|.             .||:
Mouse   306 SKYKTKIRR-LYDIANVL---SSLDLIKKVHVTEERGRKPAFKWTGPE-------------ISPN 353

  Fly   270 TSSHS----------SEDGNAPACAGNVIT--DEHGYSCNPGMKDEMKLLENE 310
            .|..|          :|......||.|:.:  .:..::.:|.:...:|.:||:
Mouse   354 NSGSSPIMPLPASLEAEQSAKENCAKNLFSTRGKPSFTRHPSLIKLVKSIEND 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	25/74 (34%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	10/74 (14%)
E2f8	NP_001013386.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	38..57
		E2F_TDP	114..182	CDD:367033	21/69 (30%)
		E2F_TDP	262..347	CDD:367033	15/92 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..433		72/378 (19%)
		PHA03247	<497..830	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	532..616
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	745..803
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810