DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E2f2 and E2f4

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_683754.1	Gene:	E2f4 / 104394	MGIID:	103012	Length:	410	Species:	Mus musculus

Alignment Length:	421	Identity:	117/421 - (27%)
Similarity:	171/421 - (40%)	Gaps:	119/421 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 DTSPDPPTPIKSPSNSQSQSQPGQQRSVGSLVLLTQKFVDLV-KANEGSIDLKAATKILDV-QKR 110
            :..|..|.|..:||..:.           ||.|||.|||.|: :|.:|.:|||.|...|.| |||
Mouse     3 EAGPQAPPPPGTPSRHEK-----------SLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKR 56

  Fly   111 RIYDITNVLEGIGLIDKGRHCSLVRWR--GGGFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEY 173
            |||||||||||||||:| :..:.::|:  |.|.|..:..:.....::....|:..|.:||:...:
Mouse    57 RIYDITNVLEGIGLIEK-KSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVW 120

  Fly   174 AQRNLRYVMQDPSNRSYAYVTRDDLLDIFGDDSVFTI--PNYDE-EVDIK-----RNHYELAVSL 230
            .|:::|.|.:|..|...||||.:|:...|..|::..|  |:... ||.|.     :..|::.:..
Mouse   121 VQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQIHLKS 185

  Fly   231 DNGSAIDIRLVTNQGKST------TNPHDVDGFFDYHRLDTPSP----------STSSHSSEDGN 279
            .:| .|::.||..:..|:      ..|.| |.......:.||.|          .:|..||....
Mouse   186 MSG-PIEVLLVNKEAWSSPPVAVPVPPPD-DLLQSPPAVSTPPPLPKPALAQPQESSPPSSPQLT 248

  Fly   280 AP------------ACAGNVITDEHGYSCNPGMKD----EMKLLENELTA--------KIIFQNY 320
            .|            ||.    |.|...|.:||.::    |:..|...|||        ..:..:.
Mouse   249 TPTPVLGSTQVSEVACQ----TSEIAVSGSPGTENKDSGEVSSLPLGLTALDTRPLQSSALLDSS 309

  Fly   321 LSGHS--------------LRRFYP--DDPN--LENP---------------------------- 339
            .|..|              ...|.|  .||.  |:.|
Mouse   310 SSSSSSSSSSSSSSSGPNPSTSFEPIKADPTGVLDLPKELSEIFDPTRECMSSELLEELMSSEVF 374

  Fly   340 -PLLQLNPP--QEDFNFALKSDEGICELFDV 367
             |||:|:||  ..|:.:.|...||:|:||||
Mouse   375 APLLRLSPPPGDHDYIYNLDESEGVCDLFDV 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	37/64 (58%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	19/61 (31%)
E2f4	NP_683754.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20		5/16 (31%)
		E2F_TDP	19..83	CDD:280479	37/75 (49%)
		Leucine-zipper	43..65		15/21 (71%)
		DEF box. /evidence=ECO:0000250	48..85		22/37 (59%)
		Dimerization. /evidence=ECO:0000255	86..181		24/94 (26%)
		E2F_DD	95..198	CDD:271137	26/103 (25%)
		coiled coil	95..130	CDD:271137	7/34 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..258		10/55 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..341		6/37 (16%)
		Transactivation. /evidence=ECO:0000255	334..410		20/72 (28%)
		HCFC1-binding-motif (HBM). /evidence=ECO:0000250	386..389		0/2 (0%)
		Interaction with RBL1 and RBL2. /evidence=ECO:0000255	387..404		6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2577
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12081
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3254
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.910