DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E2f2 and e2f4

DIOPT Version :9

Sequence 1:	NP_001286115.1	Gene:	E2f2 / 35381	FlyBaseID:	FBgn0024371	Length:	370	Species:	Drosophila melanogaster
Sequence 2:	NP_001107966.1	Gene:	e2f4 / 100038079	XenbaseID:	XB-GENE-482721	Length:	374	Species:	Xenopus tropicalis

Alignment Length:	408	Identity:	106/408 - (25%)
Similarity:	163/408 - (39%)	Gaps:	138/408 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PPTPIKSPSNSQSQSQPGQQRSVGSLVLLTQKFVDLV-KANEGSIDLKAATKILDV-QKRRIYDI 115
            |.||.:            .::|:|   |||.|||.|: :|.:|.:|||||...|.| ||||||||
Frog     8 PVTPSR------------HEKSLG---LLTSKFVSLLQEAEDGVLDLKAAADTLAVRQKRRIYDI 57

  Fly   116 TNVLEGIGLIDKGRHCSLVRWR--GGGFNNAKDQENYDLARSRTNHLKMLEDDLDRQLEYAQRNL 178
            ||||||||||:| :..:.::|:  |.|.|..:..:.....::....|:..|.:||:|..:.|:::
Frog    58 TNVLEGIGLIEK-KSKNSIQWKGVGPGCNTREIADKLIDLKAELADLEQREQELDQQRVWVQQSI 121

  Fly   179 RYVMQDPSNRSYAYVTRDDLLDIFGDDSVFTIPNYDEEVDIKRNHYELAVSLDNGSAIDIRLVTN 243
            :.|..|..|...||:|.:|:...|..|::                  ||:...:|:.:::.:..|
Frog   122 KNVTDDVQNTGLAYLTHEDICRCFRGDTL------------------LAIRAPSGTCLEVPVPEN 168

  Fly   244 QG---------KSTTNPHDVDGFFDYHRL----DTPS---------------------PS----- 269
            ..         ||||.|.:|        |    ||.|                     ||
Frog   169 TNGQKKFQIHLKSTTGPIEV--------LLVNKDTSSSPPVVVPVPPPEDLIQAPATVPSTPQRP 225

  Fly   270 --TSSHSSEDGNAPACAGNVITDEHGYSCNPGMKDEMKLLENELTAKI----------------- 315
              |..:.:.....||...:.|::.....|.   .|:...:||..::::
Frog   226 ALTPQNDTAASPVPAMPDSPISNSESQDCT---TDQTLSMENTASSRLSSIDTCPLQSSASLDNS 287

  Fly   316 --------IFQNYLSGHSLRRFYPDDPN--------------LEN-------PPLLQLNPP--QE 349
                    .||...|..|.....|.|.:              ||.       .|||:|:||  ..
Frog   288 TDLPDPSTSFQPIKSDLSDVLELPKDISDLFDQTKECITSDLLEELMSSEVFAPLLRLSPPPGDH 352

  Fly   350 DFNFALKSDEGICELFDV 367
            |:.:.|...||:|:||||
Frog   353 DYVYNLDESEGVCDLFDV 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E2f2	NP_001286115.1	E2F_TDP	77..138	CDD:280479	36/64 (56%)
E2f2	NP_001286115.1	E2F_DD	159..>218	CDD:304549	15/58 (26%)
e2f4	NP_001107966.1	E2F_TDP	14..79	CDD:367033	38/68 (56%)
		E2F_DD	91..194	CDD:271137	26/128 (20%)
		coiled coil	91..126	CDD:271137	7/34 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1087250at2759
OrthoFinder	1	1.000	-	-		FOG0000356
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12081
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.020