DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and GRAP2

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_001278753.1	Gene:	GRAP2 / 9402	HGNCID:	4563	Length:	330	Species:	Homo sapiens

Alignment Length:	370	Identity:	73/370 - (19%)
Similarity:	119/370 - (32%)	Gaps:	119/370 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   781 IAAYPYESAEEGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYV----------------- 828
            :|.:.:.::.|.:|||..|:::.::..:.||:...:||:.|..|.|::
Human     4 VAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGYVPKNFIDIQFPKWFHEGLSRHQA 68

  Fly   829 ----QKADVG--------------TASTAAAEPVESLDQETTLNGN---------------AAYT 860
                ...:||              :.|....:.|:.........||               ..|.
Human    69 ENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQHFKVMRDNKGNYFLWTEKFPSLNKLVDYYR 133

  Fly   861 AAPVEAQEQVYQPLPVQEPSEQ------------PISSPGVGAEEAHEDLDTEVS---------- 903
            ...:..|:|::.....:|....            |..|..|| ||....::.::|
Human   134 TNSISRQKQIFLRDRTREDQGHRGNSLDRRSQGGPHLSGAVG-EEIRPSMNRKLSDHPPTLPLQQ 197

  Fly   904 -QINTQSKTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIR 967
             |...|....:..|.:....|..|........:.:|.....:...:..|.   |.......:|.|
Human   198 HQHQPQPPQYAPAPQQLQQPPQQRYLQHHHFHQERRGGSLDINDGHCGTG---LGSEMNAALMHR 259

  Fly   968 KKTDSGWWEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILDKVIALYPY 1032
            :.||    ..:|||.||.|   |                                   ..|||.:
Human   260 RHTD----PVQLQAAGRVR---W-----------------------------------ARALYDF 282

  Fly  1033 KAQNDDELSFDKDDIISVLGRDEPEWWRGELNGLSGLFPSNYVGP 1077
            :|..||||.|...:::.||....|.||.|.|:...||||:|||.|
Human   283 EALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAP 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477
		EH	18..83	CDD:238009
		EH	184..279	CDD:197477
		EH	195..261	CDD:238009
		GBP_C	<366..467	CDD:303769
		TACC	369..570	CDD:282818
		coiled coil	432..443	CDD:293879
		coiled coil	457..467	CDD:293879
		TBPIP	<495..589	CDD:284512
		SH3_Intersectin_1	674..728	CDD:212770
		SH3_Intersectin_3	779..830	CDD:212772	13/69 (19%)
		SH3_Intersectin_4	941..998	CDD:212773	13/56 (23%)
		SH3_Intersectin_5	1025..1077	CDD:212774	23/51 (45%)
GRAP2	NP_001278753.1	SH3_GRAP2_N	2..53	CDD:212880	13/48 (27%)
		SH2_Grb2_like	54..147	CDD:199828	9/92 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..244		14/101 (14%)
		SH3_GRAP2_C	275..327	CDD:212883	24/86 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2056
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940