DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dap160 and TRIP10

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:XP_006723003.1 Gene:TRIP10 / 9322 HGNCID:12304 Length:649 Species:Homo sapiens


Alignment Length:465 Identity:84/465 - (18%)
Similarity:161/465 - (34%) Gaps:132/465 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   318 DPTAGLPGQNK-----RKENYVKGQAELDRR----RKIMEDQQRKEREERERKEREEADKREKAR 373
            ||.:....|..     ::.|...||.||...    |..:|..:..:..::|||...:..:|.:.:
Human    62 DPESKFSQQQSFVQILQEVNDFAGQRELVAENLSVRVCLELTKYSQEMKQERKMHFQEGRRAQQQ 126

  Fly   374 LEAERKQQEELERQLQRQREIEMEKEEQRKRELEAK-EAARKELEKQRQQEWEQARIAEMNAQKE 437
            ||...||.|..:|:.:|... |.||..|....|:.. .|.:.::||.:||...::.:||.:..:.
Human   127 LENGFKQLENSKRKFERDCR-EAEKAAQTAERLDQDINATKADVEKAKQQAHLRSHMAEESKNEY 190

  Fly   438 REQ-ERVLKQKAH--------------------NTQLNVELSTLNEKIKELSQRICDTRAGVTNV 481
            ..| :|..:.:||                    .|:|......|:|...|:...|.....|:...
Human   191 AAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELEVVPIIAKCLEGMKVA 255

  Fly   482 KTVID--------------GMRTQRDTSMSEMSQLKARIKEQNA---------KLLQLTQERAK- 522
            ...:|              |.....|....:.||...|....::         :|....:.|.| 
Human   256 ANAVDPKNDSHVLIELHKSGFARPGDVEFEDFSQPMNRAPSDSSLGTPSDGRPELRGPGRSRTKR 320

  Fly   523 WEAKSKASG-----AALGG----------------------------------------ENAQQE 542
            |....|...     :.|||                                        ..::..
Human   321 WPFGKKNKPRPPPLSPLGGPVPSALPNGPPSPRSGRDPLAILSEISKSVKPRLASFRSLRGSRGT 385

  Fly   543 QLNAAFAH------KQLIINQIKDKVENISKEIE-----SKKEDINTNDVQMSE---LKAELSAL 593
            .:...|:|      ::.:..|::::...:.||::     .|.:|:.....||.:   |:.:::..
Human   386 VVTEDFSHLPPEQQRKRLQQQLEERSRELQKEVDQREALKKMKDVYEKTPQMGDPASLEPQIAET 450

  Fly   594 ITKCEDLYKEYDVQR---------TSVLE------LKYNRKNETSVSSAWDTGSSSAWEETGTTV 643
            ::..|.|  :.:||:         :.||.      .::.|..:...|:..|:.|:||.::|..:.
Human   451 LSNIERL--KLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPASAPPDSSSNSASQDTKESS 513

  Fly   644 TDPYAVASND 653
            .:|.:..|.|
Human   514 EEPPSEESQD 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477
EH 18..83 CDD:238009
EH 184..279 CDD:197477
EH 195..261 CDD:238009
GBP_C <366..467 CDD:303769 28/122 (23%)
TACC 369..570 CDD:282818 50/297 (17%)
coiled coil 432..443 CDD:293879 1/11 (9%)
coiled coil 457..467 CDD:293879 2/9 (22%)
TBPIP <495..589 CDD:284512 21/162 (13%)
SH3_Intersectin_1 674..728 CDD:212770
SH3_Intersectin_3 779..830 CDD:212772
SH3_Intersectin_4 941..998 CDD:212773
SH3_Intersectin_5 1025..1077 CDD:212774
TRIP10XP_006723003.1 F-BAR_CIP4-like 5..257 CDD:153337 44/195 (23%)
HR1_CIP4_FNBP1L 395..475 CDD:212018 12/81 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

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