DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dap160 and FCHSD1

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_258260.1 Gene:FCHSD1 / 89848 HGNCID:25463 Length:690 Species:Homo sapiens


Alignment Length:654 Identity:130/654 - (19%)
Similarity:237/654 - (36%) Gaps:193/654 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   336 GQAEL---DRRRKIMEDQQRKEREERERKEREEADKREKARLEAERKQQEELE--RQLQRQREIE 395
            ||..|   ||.|.:.....|..:|:..||..|          ..:|.|.|.|:  |:|.|.|   
Human    97 GQTRLQASDRYRDLAGGTGRSAKEQVLRKGTE----------NLQRAQAEVLQSVRELSRSR--- 148

  Fly   396 MEKEEQRKRELEAKEAARKELEKQRQQEW--EQARIAEMNAQKEREQERVLKQKAHNTQLNVELS 458
                               :|..||::.|  .|.:.|::.|:..|....:...:....:|:.:||
Human   149 -------------------KLYGQRERVWALAQEKAADVQARLNRSDHGIFHSRTSLQKLSTKLS 194

  Fly   459 TLNEKIKELSQ--------RICDTRAGVTN---------VKTVIDGMRTQ-RD--TSMSEMSQLK 503
            ..:.:..:..|        .:..|.|.:.:         :|.::..:... ||  ||:|......
Human   195 AQSAQYSQQLQAARNEYLLNLVATNAHLDHYYQEELPALLKALVSELSEHLRDPLTSLSHTELEA 259

  Fly   504 ARIKEQNAKLLQLTQERAKWEAKSK-------------------------------ASG-AALGG 536
            |.:..::|...:.|..:..||...|                               |.| |...|
Human   260 AEVILEHAHRGEQTTSQVSWEQDLKLFLQEPGVFSPTPPQQFQPAGTDQVCVLEWGAEGVAGKSG 324

  Fly   537 ENAQQEQLNAAFA-------HKQLIINQIKDKVENISK----EIESKKEDI--NTNDVQMSELK- 587
            ...:.::|.:..|       |...::.:::.:.:..|:    .||.:.:::  :....|:|::| 
Human   325 LEKEVQRLTSRAARDYKIQNHGHRVLQRLEQRRQQASEREAPSIEQRLQEVRESIRRAQVSQVKG 389

  Fly   588 -AELSAL--------------ITKCEDLYKEYDVQRTSVLELKYNRKNETSVSSAWDTGSSSAWE 637
             |.|:.|              :|:.:|   |.:.:| .:.|.:.::::.:..:...:.......|
Human   390 AARLALLQGAGLDVERWLKPAMTQAQD---EVEQER-RLSEARLSQRDLSPTAEDAELSDFEECE 450

  Fly   638 ETGTTVTDPYAVASNDISALAAPAVDLGGPAPEGFVKYQAVYEFNARNAEEITFVPGDIILVPLE 702
            |||....:|..      .|||..|:    |.|.     ..|:.:.|...:|:|...|:.:.|..|
Human   451 ETGELFEEPAP------QALATRAL----PCPA-----HVVFRYQAGREDELTITEGEWLEVIEE 500

  Fly   703 QNAEPGWLAGEINGHTGWFPESYVEKLEVGEVAPVAAVEAPVDAQVATVADTYNDNINTSSIPAA 767
            .:|:....|...:|..|:.||.|:                               |....|:|.:
Human   501 GDADEWVKARNQHGEVGFVPERYL-------------------------------NFPDLSLPES 534

  Fly   768 S--ADLTAAGDVEYYIA----AYPYESAEEGDLSFSAGEMVMVIKK-----EGEWWTGTIGSRTG 821
            |  :|.....:...::|    :|..:||||  |||..|.::.::.:     :..:|.|..|.|.|
Human   535 SQDSDNPCGAEPTAFLAQALYSYTGQSAEE--LSFPEGALIRLLPRAQDGVDDGFWRGEFGGRVG 597

  Fly   822 MFPSNYVQKADVGTASTAAAEPVESLDQETTLNGNAAYTAAPVEAQEQVYQ--PLPVQEPSEQPI 884
            :|||..|::. :|...     |.|..|.|..|...:..:.:| .|...|..  |.||. |.::.:
Human   598 VFPSLLVEEL-LGPPG-----PPELSDPEQMLPSPSPPSFSP-PAPTSVLDGPPAPVL-PGDKAL 654

  Fly   885 SSPG 888
            ..||
Human   655 DFPG 658

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477
EH 18..83 CDD:238009
EH 184..279 CDD:197477
EH 195..261 CDD:238009
GBP_C <366..467 CDD:303769 19/104 (18%)
TACC 369..570 CDD:282818 42/267 (16%)
coiled coil 432..443 CDD:293879 2/10 (20%)
coiled coil 457..467 CDD:293879 2/9 (22%)
TBPIP <495..589 CDD:284512 21/140 (15%)
SH3_Intersectin_1 674..728 CDD:212770 14/53 (26%)
SH3_Intersectin_3 779..830 CDD:212772 19/59 (32%)
SH3_Intersectin_4 941..998 CDD:212773
SH3_Intersectin_5 1025..1077 CDD:212774
FCHSD1NP_258260.1 F-BAR_FCHSD1 16..275 CDD:153362 42/209 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..444 2/22 (9%)
SH3_FCHSD_1 470..526 CDD:212695 16/91 (18%)
SH3_FCHSD1_2 550..607 CDD:212828 19/58 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 609..690 15/57 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2056
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.