DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dap160 and EDE1

DIOPT Version :9

Sequence 1:NP_001246118.1 Gene:Dap160 / 35378 FlyBaseID:FBgn0023388 Length:1190 Species:Drosophila melanogaster
Sequence 2:NP_009506.1 Gene:EDE1 / 852233 SGDID:S000000143 Length:1381 Species:Saccharomyces cerevisiae


Alignment Length:1255 Identity:248/1255 - (19%)
Similarity:446/1255 - (35%) Gaps:393/1255 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 DAWAVTPRERLKYQEQFRALQPQAGFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINE 70
            |..|::..:..|:.:.|......|..|.|.:||..||:::||...||:||||.|.|:.|.::.:|
Yeast   127 DIPALSSNDIAKFSQLFDRTAKGAQTVAGDKAKDIFLKARLPNQTLGEIWALCDRDASGVLDKSE 191

  Fly    71 FSIACKLINLKLR---GMDV-PKVLPPSLLSSLTGDVPSMTPRGSTSSLSPLDPLKGIVPAVAPV 131
            |.:|..||.|.:.   .|:. |.|||..|..|:                           .:.||
Yeast   192 FIMAMYLIQLCMSHHPSMNTPPAVLPTQLWDSI---------------------------RLEPV 229

  Fly   132 VPVVAPPVAVATVISPPGVSVPSGPTPPTSNPP-----SRHTSISERAPSIESVNQGEWAVQAAQ 191
            |                 |:.|:..||.::|..     :||::||..:....|....:|::...:
Yeast   230 V-----------------VNQPNRTTPLSANSTGVSSLTRHSTISRLSTGAFSNAASDWSLSFEK 277

  Fly   192 KRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLAQIWTLSDIDGDGRLNCDEFILAMFLC 256
            |:::..:|::.|:..:|.|:.:......:.|:|.|.|||.||.|:||..:......||.:||||.
Yeast   278 KQQFDAIFDSLDKQHAGSLSSAVLVPFFLSSRLNQETLATIWDLADIHNNAEFTKLEFAIAMFLI 342

  Fly   257 EKAMAGEKIPVTLPQEWV--------PPN-LRKIKSRPG-SVSGVVSRPGSQPASRHAS---VSS 308
            :|..||.::|..:|.|.:        ||| |.:.:|.|. ::....|:|..|......|   |::
Yeast   343 QKKNAGVELPDVIPNELLQSPALGLYPPNPLPQQQSAPQIAIPSRASKPSLQDMPHQVSAPAVNT 407

  Fly   309 QSGV--------------GVVDADPTAGLPG--------QNKRKENYV----KGQAELDRRRKIM 347
            |..|              .::..:|:...|.        ||....::.    .|||.|.::    
Yeast   408 QPTVPQVLPQNSNNGSLNDLLALNPSFSSPSPTKAQTVVQNNTNNSFSYDNNNGQATLQQQ---- 468

  Fly   348 EDQQR------------------------KEREERERKEREE----------------------- 365
            :.||.                        ||..|.:.:.||.                       
Yeast   469 QPQQPPPLTHSSSGLKKFTPTSNFGQSIIKEEPEEQEQLRESSDTFSAQPPPVPKHASSPVKRTA 533

  Fly   366 ---------------------------------------------------------ADKREKAR 373
                                                                     ||....|:
Yeast   534 STTLPQVPNFSVFSMPAGAATSAATGAAVGAAVGAAALGASAFSRSSNNAFKNQDLFADGEASAQ 598

  Fly   374 LEAERKQQEELERQ---LQRQREIEMEKE----EQRKRELEAKEAARKELEKQR--------QQE 423
            |.....:...|..|   |.:|..|..:|:    ::.||..|.|.:.:.:|...|        |.|
Yeast   599 LSNATTEMANLSNQVNSLSKQASITNDKKSRATQELKRVTEMKNSIQIKLNNLRSTHDQNVKQTE 663

  Fly   424 WEQARIAEMNAQKEREQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGM 488
            ..:|::.::|.:.|...:::...:|:......:|:.|...::|...:..:.:..:||:.::...:
Yeast   664 QLEAQVLQVNKENETLAQQLAVSEANYHAAESKLNELTTDLQESQTKNAELKEQITNLNSMTASL 728

  Fly   489 RTQRDTSMSEMSQLKARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQE-----QLNAAF 548
            ::|.:....::.|.::.: :.|:|.|:|.|...               .|.|:|     :..:.:
Yeast   729 QSQLNEKQQQVKQERSMV-DVNSKQLELNQVTV---------------ANLQKEIDGLGEKISVY 777

  Fly   549 AHKQLIINQIKDKVENISKEIESKKEDINTNDVQMSELKAEL---SALITKCEDLYKEYDVQRTS 610
            ..||..:|..:..||....::::|.:|::..|..:::.:.:|   :..|.:.|:||.    |..|
Yeast   778 LTKQKELNDYQKTVEEQHAQLQAKYQDLSNKDTDLTDREKQLEERNRQIEEQENLYH----QHVS 838

  Fly   611 VLELKYNRKNETSVSSAWDTGSSSAWEETGTTVTDPYAVASNDISALAAPAVDLG-GPAPEGFVK 674
            .|:..::..::...|          :|:....:.:.....:|::..|:...::|. |..||   .
Yeast   839 KLQEMFDDLSQRKAS----------FEKADQELKERNIEYANNVRELSERQMNLAMGQLPE---D 890

  Fly   675 YQAVYEFNARNAEEITFVPGDIILVPLEQNAEPGWLAGEINGHT-GWFPESYVE--KLEVGEV-- 734
            .:.:...:|.|.:..|               :.....|.::..| ..|.|:.||  .|.|..|  
Yeast   891 AKDIIAKSASNTDTTT---------------KEATSRGNVHEDTVSKFVETTVENSNLNVNRVKD 940

  Fly   735 --APVAAVEAPV-DAQVATV---ADTYNDNINT---SSIPAASADLTAAGDVEYYIAAYPYESAE 790
              ......|:.| |..|.|:   :|:.|.|.|.   |....|:.:||......:           
Yeast   941 DEEKTERTESDVFDRDVPTLGSQSDSENANTNNGTQSGNETANPNLTETLSDRF----------- 994

  Fly   791 EGDLSFSAGEMVMVIKKEGEWWTGTIGSRTGMFPSNYVQ--KADVGTASTAAAEPVESLDQETTL 853
            :|||:              |:......|.|....:|..|  :.||        |..|:|::..|:
Yeast   995 DGDLN--------------EYGIPRSQSLTSSVANNAPQSVRDDV--------ELPETLEERDTI 1037

  Fly   854 N--------GNAAYTAAPVEAQEQVYQPLPVQEPSEQPISSPGVGAEEAHEDLDTEVSQI-NTQS 909
            |        ||.::.....||                   :|...:.:...:..|||.:. :|..
Yeast  1038 NNTANRDNTGNLSHIPGEWEA-------------------TPATASTDVLSNETTEVIEDGSTTK 1083

  Fly   910 KTQSSEPAESYSRPMSRTSSMTPGMRAKRSEIAQVIAPYEATSTEQLSLTRGQLIMIRKKTDSGW 974
            :..|:|..||.|   |...|.....:.|...|.:...|.             |.:.|.:...|..
Yeast  1084 RANSNEDGESVS---SIQESPKISAQPKAKTINEEFPPI-------------QELHIDESDSSSS 1132

  Fly   975 WEGELQAKGRRRQIGWFPATYVKVLQGGRNSGRNTPVSGSRIEMTEQILD--------------- 1024
            .:.|.:   ..|:|   |:..||.||...|:   .|.|...|. |||::.               
Yeast  1133 DDDEFE---DTREI---PSATVKTLQTPYNA---QPTSSLEIH-TEQVIKYPAPGTSPSHNEGNS 1187

  Fly  1025 ---KVIALYPYKAQNDDELS 1041
               ...::.|.|.:.|||.:
Yeast  1188 KKASTNSILPVKDEFDDEFA 1207

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dap160NP_001246118.1 EH 7..101 CDD:197477 34/97 (35%)
EH 18..83 CDD:238009 25/64 (39%)
EH 184..279 CDD:197477 32/103 (31%)
EH 195..261 CDD:238009 22/65 (34%)
GBP_C <366..467 CDD:303769 24/115 (21%)
TACC 369..570 CDD:282818 40/220 (18%)
coiled coil 432..443 CDD:293879 2/10 (20%)
coiled coil 457..467 CDD:293879 2/9 (22%)
TBPIP <495..589 CDD:284512 17/98 (17%)
SH3_Intersectin_1 674..728 CDD:212770 9/56 (16%)
SH3_Intersectin_3 779..830 CDD:212772 8/52 (15%)
SH3_Intersectin_4 941..998 CDD:212773 10/56 (18%)
SH3_Intersectin_5 1025..1077 CDD:212774 5/17 (29%)
EDE1NP_009506.1 EH 9..101 CDD:197477
EH 128..221 CDD:197477 32/92 (35%)
EH 270..363 CDD:197477 29/92 (32%)
Atrophin-1 <355..>528 CDD:397323 30/176 (17%)
Smc <595..877 CDD:224117 55/311 (18%)
PRK08581 903..>1111 CDD:236304 55/277 (20%)
UBA_scEDE1_like 1345..1379 CDD:270471
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 56 1.000 Domainoid score I2711
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR11216
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.970

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