DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dap160 and AT1G20760

DIOPT Version :9

Sequence 1:	NP_001246118.1	Gene:	Dap160 / 35378	FlyBaseID:	FBgn0023388	Length:	1190	Species:	Drosophila melanogaster
Sequence 2:	NP_173499.1	Gene:	AT1G20760 / 838666	AraportID:	AT1G20760	Length:	1019	Species:	Arabidopsis thaliana

Alignment Length:	957	Identity:	208/957 - (21%)
Similarity:	311/957 - (32%)	Gaps:	354/957 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 EQFRALQPQA-----GFVTGAQAKGFFLQSQLPPLILGQIWALADTDSDGKMNINEF-------- 71
            :||.|...:|     |.::||:|.|||..|.|...:|.|||:|:|....|.::...|
plant     9 DQFEAYFKRADLDGDGRISGAEAVGFFQGSGLSKQVLAQIWSLSDRSHSGFLDRQNFYNSLRLVT 73

  Fly    72 ------SIACKLINLKLRGMDVPKVLPPSL-LSSLTGDVPS------------------------ 105
                  .:..:::|..|......|:.||.: ||::....|:
plant    74 VAQSKRDLTPEIVNAALNTPAAAKIPPPKINLSAIPAPRPNPAATTVGPVSGFGGPGAPNAIVNQ 138

  Fly   106 ----------MTPRGSTSSLSPLDPLKG--IVPAV-------APVVPVVAPPVAVATVISPPGVS 151
                      |.|....|.|:.|.|..|  ..|:.       .||..|..||..|.|.:|.||.|
plant   139 NYFPPQQNQQMRPNQGISGLTSLRPAAGPEYRPSALSGQFQPVPVGSVTHPPQPVPTSVSGPGSS 203

  Fly   152 V----------------PSG--------PTP---------------------------------- 158
            .                .||        |:|
plant   204 TFNLNSLYAGAGNTSGYSSGFGGGSLAAPSPGLKQESHIDPKALVVSGNGGDMFSSFQQKQEPTL 268

  Fly   159 ----------PTS---NPP-----------------------------SRHTSISERAPSI---- 177
                      |||   .||                             |...::|.:.||.
plant   269 SNSSISSAIVPTSAGIQPPTKPNALDSLQSTFSMLPSGNQLQQPRPAASSQPAVSSQGPSSGLPP 333

  Fly   178 -----------ESVNQGEW-AVQAAQKRKYTQVFNANDRTRSGYLTGSQARGVLVQSKLPQVTLA 230
                       ...||..| .::.:..:|||:||...|..:.|.:||.|||.:.:..:||:..|.
plant   334 GSAVGSGHSTPAGNNQPPWPKMKPSDVQKYTKVFMEVDSDKDGKITGEQARNLFLSWRLPREVLK 398

  Fly   231 QIWTLSDIDGDGRLNCDEFILAMFLCEKAMAGEKIPVTLPQE-WVPPNLRKIKSRP--------- 285
            .:|.|||.|.|..|:..||.::::|.|:...|..:|..||.. .....|..|...|
plant   399 HVWELSDQDNDTMLSLREFCISLYLMERYREGRPLPTALPSSIMFDETLLSISGAPSHGYANAGW 463

  Fly   286 GSVSGVVSRPGSQPASRHASVSSQSGVGVVDADPTAGLPGQNKR--------------------- 329
            ||..|.|.:||........:...:..|......|.:|:|....|
plant   464 GSGQGFVQQPGMGARPITPTTGMRPPVPAPGPQPGSGIPPNQPRNQAPVLDAPFANHLGNGYSAS 528

  Fly   330 ---------------KEN-YVKGQAELDRRRKIMED----QQRKEREERERKEREEADKREKARL 374
                           |:| |:..:.:||..|..|:|    :.|.:....|..||..|||||   .
plant   529 SNLPEAAADEEKVDEKQNAYMDSREKLDYYRTKMQDIVLYKSRCDNRLNEISERASADKRE---A 590

  Fly   375 EAERKQQEELERQLQRQREI--EMEKEEQRKRELEAKEAARKELEKQRQQEWEQARIAEMNAQKE 437
            |...|:.||..:|:   .||  ::..||.|.||:|.           |:.|..||.:   |.::.
plant   591 ETLAKKYEEKYKQV---AEIGSKLTIEEARFREIEG-----------RKMELSQAIV---NMEQG 638

  Fly   438 REQERVLKQKAHNTQLNVELSTLNEKIKELSQRICDTRAGVTNVKTVIDGMRTQRDTSMSEMSQL 502
            ...:.:|:.:|...|     |.|.|.:|.|::| |.......|.|.::|
plant   639 GSADGLLQVRADRIQ-----SDLEELMKALTER-CKKHGLEVNSKALVD---------------- 681

  Fly   503 KARIKEQNAKLLQLTQERAKWEAKSKASGAALGGENAQQEQLNAAFAHKQLIINQIKDKVENISK 567
                            ..|.|:...: .||||..|...:.: :..|.::   |...|.|.:|.|.
plant   682 ----------------LPAGWQPGIQ-EGAALWDEEWDKFE-DEGFGNE---ITFDKSKEQNSSG 725

  Fly   568 EIESKKED-----------INTNDVQMSEL-----KAELSALITKCEDLY-KEYDVQR--TSVLE 613
            |.|:...|           :..|....||.     ::|...  |..||.. ::..|.|  |.|..
plant   726 EKENGTVDDGSGPPDSPTHVEDNYGPFSETSDRHHESEYGT--THSEDRSPRDSPVSRNATEVPS 788

  Fly   614 LKYNR-KN-----ETSVSSAWDTGS--SSAWEETGTTVTDPYAVASNDISALAAPAVDLGG---- 666
            ..|:: ||     :::.:||:||..  .|.|....:...|.....|.|         |.||
plant   789 PDYSQGKNSEFFDDSNWASAFDTNDDVDSVWGFDASKSQDGDYFGSGD---------DFGGNTAR 844

  Fly   667 -PAPEGFVKYQAVYEFNARNAEEITF---VPGDIILVPLEQ--NAEP 707
             .:|..       ..|.|:...:..|   ||.    .||.:  |:.|
plant   845 ADSPSS-------RSFGAQRKSQFAFDDSVPS----TPLSRFGNSPP 880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dap160	NP_001246118.1	EH	7..101	CDD:197477	28/100 (28%)
		EH	18..83	CDD:238009	22/81 (27%)
		EH	184..279	CDD:197477	31/96 (32%)
		EH	195..261	CDD:238009	25/65 (38%)
		GBP_C	<366..467	CDD:303769	30/102 (29%)
		TACC	369..570	CDD:282818	47/202 (23%)
		coiled coil	432..443	CDD:293879	1/10 (10%)
		coiled coil	457..467	CDD:293879	4/9 (44%)
		TBPIP	<495..589	CDD:284512	19/109 (17%)
		SH3_Intersectin_1	674..728	CDD:212770	9/39 (23%)
		SH3_Intersectin_3	779..830	CDD:212772
		SH3_Intersectin_4	941..998	CDD:212773
		SH3_Intersectin_5	1025..1077	CDD:212774
AT1G20760	NP_173499.1	EH	11..77	CDD:238009	20/65 (31%)
		EH	351..441	CDD:197477	31/89 (35%)
		EH	363..429	CDD:238009	25/65 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	60	1.000	Domainoid score	I3847
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1020
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11216
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100